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Erschienen in:
21.07.2016 | Originalien
Plasma melatonin levels do not differ in SLE patients
Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 1/2018
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Objective
This study aims to investigate the plasma melatonin levels in systemic lupus erythematosus (SLE) patients and its relationship with clinical and laboratory features.
Patients and methods
A total of 90 patients with SLE (82 females, 8 males; mean age 37.86 ± 13.98 years, range 19–77 years) and 90 healthy controls (82 females, 8 male; mean age 36.54 ± 10.89 years, range 22–60 years) were recruited for the current study. Plasma melatonin levels were detected by enzyme-linked immunosorbent assay.
Results
Melatonin levels were not significantly different in the plasma of patients with SLE compared with controls (P = 0.026). There was no significant difference regarding plasma melatonin level between SLE patients with nephritis and those without nephritis (P = 0.714); no significant difference was found between less active SLE and more active SLE (P = 0.791). The presence of IgM was associated with melatonin levels (P = 0.031) in SLE patients.
Conclusions
There is no significant difference in plasma melatonin levels between SLE patients and controls. Further studies are needed to elucidate the role of melatonin in SLE.