Skip to main content

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Journal of Orthopaedic Surgery and Research 1/2018

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

Journal of Orthopaedic Surgery and Research > Ausgabe 1/2018
Ju Tang, Wei Zhu, Xiaoliang Mei, Zhenxiang Zhang



The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA.


Eligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT.


A total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04–1.29; p = 0.011).


Our study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2018

Journal of Orthopaedic Surgery and Research 1/2018 Zur Ausgabe

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.