Introduction
The clavicle is one of the most commonly fractured bones, accounting for 5–10% of all fractures. Around 80% of clavicle fractures involve the midshaft and over half of these fractures are displaced [
1,
2]. Traditionally acute displaced midshaft clavicular fractures (DMCF) have been treated conservatively, with the expectation that even severe radiographic malalignment would not influence functional results [
3].
However, recent studies have uncovered the disadvantages of conservatively treated DMCF [
4‐
6]. The relatively high number of non-unions, residual deficits in shoulder strength and endurance, persistent pain and disappointing cosmetic results might have led to unsatisfactory results in approximately 30% of the patients with DMCF [
4‐
6]. Therefore there is a tendency towards surgical treatment for DMCF [
7,
8].
Open reduction and internal plate fixation and intramedullary fixation are two of the most commonly used surgical techniques for treating DMCF [
7,
8]. For plate fixation different types of plates are available: (precontoured) dynamic compression plates (DCP) [
9], tubular plates or reconstruction plates [
10]. For intramedullary fixation the Knowles pin [
11], Rockwood pin [
12] or elastic stable intramedullary nailing (ESIN) using a titanium elastic nail (TEN) [
13] have been described. In recently published prospective randomised studies, functional results after both plate fixation and intramedullary fixation proved to be superior compared to nonoperative treatment of DMCF [
15,
16]. This was also underlined by the systematic review by Zlowodzki et al. that reported a relative risk reduction of 86% (plate fixation) and 87% (intramedullary fixation) for non-union compared with conservative treatment [
14].
Theoretically, both plate fixation and intramedullary fixation have their own advantages. A biomechanical study shows that plate fixation provides a more rigid stabilisation compared to intramedullary fixation and may provide a stronger construction for early rehabilitation protocols [
17]. On the other hand, intramedullary fixation has the advantage of preserving the soft tissue envelope, periosteum, and vascular integrity of the fracture site. Therefore infection rates may be decreased and fracture callus formation enhanced [
18].
The optimal surgical approach for DMCF remains controversial. Only one systematic review addressed the different surgical methods but at that time could not include multiple studies comparing plate fixation versus intramedullary fixation [
19]. The goals of this systematic review are (1) to compare functional outcome and complications after plate fixation and intramedullary fixation for DMCF and (2) to assess the scientific quality of the available evidence.
Methods
Search strategy
A computer aided search of PUBMED and Embase was carried out on January 11th 2011. In PUBMED the first two phases of the optimal trial search strategy (
www.cochrane-handbook.org) were combined with the subject specific search. In addition the reference lists of identified studies were searched (reference tracking) and studies that cited these studies where screened (citation tracking).
Inclusion criteria
Studies that compared plate fixation with intramedullary fixation in patients with acute unilateral DCMF were included. Dislocation or displacement had to be mentioned in the criteria of the study for inclusion in this review. Every study that was published in the English, German, French or Dutch language, except review articles or case reports, was considered for inclusion. Studies that assessed clavicular malunion or non-union, fractures with initial nonoperative treatment or biomechanical studies were excluded.
Selection of studies
Three independent reviewers (RMH, FJW, CSB) screened the titles and abstracts of identified studies for eligibility. The full text articles were read for inclusion. Disagreement between the reviewers was resolved by discussion with another independent reviewer (MCK).
Quality assessment
Two reviewers (RMH, CSB) independently assessed various aspects of methodological quality of the included studies without masking the source or authorship of trial reports (Table
1). The modified version of the Cochrane Bone, Joint and Muscle Trauma Group’s former quality assessment tool was used. This tool consists of 11 items: the first seven items relate to bias (internal validity), and the remaining four items relate to external validity. Furthermore, they scored the included studies according to the GRADE approach (
www.cochrane-handbook.org). The GRADE approach is a quality tool that specifies four levels of evidence (high, moderate, low and very low). The highest quality rating is for randomised trial evidence, while moderate quality is for downgraded randomised trials or upgraded observational studies. Low quality rating is reserved for double-downgraded randomised trials or observational studies and finally very low quality is for triple-downgraded randomised trials, downgraded observational studies or case series/case reports. A study can be downgraded one or more levels for every limitation factor a review author finds (limitations in the design, imprecise results, indirectness of evidence, high probability of publication bias and unexplained heterogeneity or inconsistency of results). Disagreement between the reviewers about the quality assessment was resolved by discussion with another independent reviewer (MCK).
Table 1
Quality assessment
Allocation concealment | 2 | 0 | 0 | 0 |
Intention-to-treat analysis | 2 | 0 | 0 | 0 |
Assessor blinding | 0 | 0 | 0 | 0 |
Comparable baseline characteristics | 2 | 2 | 2 | 0 |
Participant blinding | 0 | 0 | 0 | 0 |
Treatment provider blinding | 0 | 0 | 0 | 0 |
Care program comparability | 2 | 2 | 0 | 0 |
Defined in- and exclusion criteria | 2 | 2 | 2 | 2 |
Well defined interventions | 2 | 2 | 1 | 2 |
Well defined outcome measures | 2 | 2 | 2 | 2 |
Clinically useful diagnostic tests | 2 | 2 | 0 | 2 |
Adequate duration of follow-up | 2 | 2 | 0 | 0 |
QAT-Score | 18 | 14 | 7 | 8 |
Grade | High | Very low | Very low | Low |
Data extraction and analysis
Included studies were summarised in a data-extraction form, including the following items: type of study, surgery (type of plate fixation or specified method of intramedullary fixation), descriptive data (sample size, missing data, follow-up), patient characteristics, functional outcome, operation characteristics (amount of blood loss and duration of the surgery) and complications. Functional outcome was defined as shoulder function with the Disabilities of the Arm, Shoulder and Hand (DASH) and Constant scores [
20,
21]. The DASH questionnaire is a self administered outcome instrument developed as a measure of self-rated upper extremity disability and symptoms. The Constant score includes an analysis of pain, shoulder motion, strength, and function. Definitions were used according to the definitions of the authors in the different studies. Data were presented as mean ± standard deviation or as percentages. Because of the different study designs and characteristics, data could not be pooled and the data were summarised separately for each study.
Discussion
High quality evidence from one study and low quality evidence from three studies showed no difference in functional outcome and complications after plate fixation or intramedullary fixation for DMCF [
23‐
26]. However, only one high quality RCT was identified with relatively small sample sizes per condition (
n = 15 for plate fixation;
n = 17 for intramedullary fixation) [
23]. Furthermore, it is difficult to draw conclusions concerning complications as all group sizes were small. Therefore, future high quality studies comparing plate fixation and intramedullary fixation with sufficient power are needed to aid evidence-based decisions about surgical management of DMCF.
Our findings are in agreement with the previous review by Lenza et al. They stated that there was limited evidence about the superiority of one surgical approach for DMCF above another [
19]. However, they found only one comparative study in the scope of this review [
22]. In this comparative study, Lee et al. did not report if there was displacement of the fracture. Due to our inclusion criteria we excluded this study.
Both surgical procedures have their own (dis)advantages. Plate fixation is technically easy to perform and long-term experience is available. With improved implants, prophylactic antibiotics, and better soft-tissue handling, plate fixation has been a reliable and reproducible technique [
15]. Despite experience and improvement, plate fixation is not free from complications. Typical complications of plate fixation include infection, hypertrophic scars, implant loosening, nonunion and refracture after implant removal [
27,
28]. Compared to plate fixation, intramedullary fixation is technically more demanding [
29]. In approximately 50% of the patients open reduction was necessary to reduce the fracture. The main complications are migration and perforation of the device [
16,
29‐
32] and one iatrogenic brachial plexus injury is described [
33]. Nevertheless, several studies describe excellent results after intramedullary fixation of DMCF with significant improvement of shoulder function, reduction of pain postoperatively, good cosmetic results and minimal non-union rates [
16,
29‐
32].
A disadvantage of clavicular surgery in general is the putative need for implant removal and therefore a second operation. Implant removal is standard treatment offered to all patients after intramedullary fixation. The rationale behind implant removal is to prevent migration of the implant even in designs that provide locking bolts. In some patients implant removal of intramedullary fixation can be performed using local anaesthesia [
16]. A possible advantage of plate fixation is that implant removal is less often required. However, prominence of the plate will usually cause some patient discomfort. Exact numbers on plate removal differ between studies but vary from 0 up to 74% of the cases [
34,
35].
The following limitations of this review have to be addressed. In the current literature, dislocation (or displacement) is often poorly defined which might lead to heterogenity of the results. For example, exact definitions of displacement and shortening were lacking in the study of Ferran et al. [
23]. In another comparative study displacement was not even described [
22]. Proceedings from annual meetings (conferences) were not included in this review. Only PUBMED, EMBASE and the Cochrane databases were used for search. Therefore some valuable information might be lost. However, at proceedings mostly interim analyses are reported and these results might differ from the final results. PUBMED and EMBASE are the largest medical databases. The Cochrane database showed one review by Lenza et al. [
19]. This review contained only one comparative study in the scope of this review [
22]. Therefore we feel confident in having assessed all relevant available evidence. However, the authors realise the amount of available literature is small, but this emphasises the need for future high quality studies comparing plate fixation and intramedullary fixation with sufficient power to aid physicians in making evidence-based decisions about surgical treatment of DMCF. Prospective cohort series of plate fixation or intramedullary fixation were not included in this review. These studies might provide a great deal of information regarding complications of both procedures. However, due to heterogenity of these studies, pooling of the data and subgroup analyses are difficult to perform.
We conclude that despite the limited number of prospective comparative studies at this moment, there is evidence that functional outcomes are not influenced by the method of surgical treatment of displaced midshaft clavicle fractures, plate fixation or intramedullary fixation.