Skip to main content
Erschienen in: European Archives of Oto-Rhino-Laryngology 2/2018

23.12.2017 | Head and Neck

Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer

verfasst von: Yize Mao, Yan Fu, Yunfei Gao, Ankui Yang, Quan Zhang

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Objectives

Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients.

Methods

We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC. The patients were stratified by PLR into three subgroups: low (≤ 119.55), moderate (> 119.55 and ≤ 193.55), and high (> 193.55). Kaplan–Meier curves were plotted to compare the intergroup cancer-specific survival (CSS).

Results

Patients with high PLR had significantly worse survival outcomes (5-year CSS, low vs. moderate vs. high: 75.3 vs. 68.4 vs. 53.9%; 10-year CSS, low vs. moderate vs. high: 65.0 vs. 56.0 vs. 38.6%, P < 0.001). Patients with PLR > 193.55 represented malnutrition and more advanced cancer stage..

Conclusion

Patients with PLR > 193.55 experience poor outcomes and represent malnutrition, more advanced cancer stage.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
2.
Zurück zum Zitat Carvalho AL, Nishimoto IN, Califano JA, Kowalski LP(2005) Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer 114:806–816CrossRefPubMed Carvalho AL, Nishimoto IN, Califano JA, Kowalski LP(2005) Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer 114:806–816CrossRefPubMed
3.
Zurück zum Zitat Connor KL, Pattle S, Kerr GR, Junor E (2015) Treatment, comorbidity and survival in stage III laryngeal cancer. Head Neck 37:698–706CrossRefPubMed Connor KL, Pattle S, Kerr GR, Junor E (2015) Treatment, comorbidity and survival in stage III laryngeal cancer. Head Neck 37:698–706CrossRefPubMed
4.
Zurück zum Zitat Hoffman HT, Porter K, Karnell LH et al (2006) Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 116:1–13CrossRefPubMed Hoffman HT, Porter K, Karnell LH et al (2006) Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 116:1–13CrossRefPubMed
5.
6.
Zurück zum Zitat van Oijen MG, Slootweg PJ (2000) Gain-of-function mutations in the tumor suppressor gene p53. Clin Cancer Res 6:2138–2145PubMed van Oijen MG, Slootweg PJ (2000) Gain-of-function mutations in the tumor suppressor gene p53. Clin Cancer Res 6:2138–2145PubMed
7.
Zurück zum Zitat Trask DK, Wolf GT, Bradford CR et al. (2002) Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. Laryngoscope 112:638–644CrossRefPubMed Trask DK, Wolf GT, Bradford CR et al. (2002) Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. Laryngoscope 112:638–644CrossRefPubMed
8.
Zurück zum Zitat Maurizi M, Almadori G, Ferrandina G et al (1996) Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. Br J Cancer 74:1253–1257CrossRefPubMedPubMedCentral Maurizi M, Almadori G, Ferrandina G et al (1996) Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. Br J Cancer 74:1253–1257CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Chen J, Zhou J, Lu J, Xiong H, Shi X, Gong L (2014) Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis. BMC Cancer 14:15CrossRefPubMedPubMedCentral Chen J, Zhou J, Lu J, Xiong H, Shi X, Gong L (2014) Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis. BMC Cancer 14:15CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Gomez D, Farid S, Malik HZ et al (2008) Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 32:1757–1762CrossRefPubMed Gomez D, Farid S, Malik HZ et al (2008) Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 32:1757–1762CrossRefPubMed
12.
Zurück zum Zitat McMillan DC, Canna K, McArdle CS (2003) Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 90:215–219CrossRefPubMed McMillan DC, Canna K, McArdle CS (2003) Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 90:215–219CrossRefPubMed
13.
Zurück zum Zitat Izano M, Wei EK, Tai C et al (2016) Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study. Int J Cancer 138:1118–1128CrossRefPubMed Izano M, Wei EK, Tai C et al (2016) Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study. Int J Cancer 138:1118–1128CrossRefPubMed
14.
Zurück zum Zitat Klinger MH, Jelkmann W.(2002) Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 22:913–922CrossRefPubMed Klinger MH, Jelkmann W.(2002) Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 22:913–922CrossRefPubMed
15.
Zurück zum Zitat Salazar-Onfray F, Lopez MN, Mendoza-Naranjo A.(2007) Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Fact Rev 18:171–182CrossRef Salazar-Onfray F, Lopez MN, Mendoza-Naranjo A.(2007) Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Fact Rev 18:171–182CrossRef
16.
Zurück zum Zitat Clarke SJ, Chua W, Moore M et al (2011) Use of inflammatory markers to guide cancer treatment. Clin Pharmacol Ther 90:475–478CrossRefPubMed Clarke SJ, Chua W, Moore M et al (2011) Use of inflammatory markers to guide cancer treatment. Clin Pharmacol Ther 90:475–478CrossRefPubMed
17.
Zurück zum Zitat Templeton AJ, Ace O, McNamara MG et al (2014) Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomark Preven Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 23:1204–1212CrossRef Templeton AJ, Ace O, McNamara MG et al (2014) Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomark Preven Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 23:1204–1212CrossRef
18.
Zurück zum Zitat Krenn-Pilko S, Langsenlehner U, Thurner EM et al (2014) The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients. Br J Cancer 110:2524–2530CrossRefPubMedPubMedCentral Krenn-Pilko S, Langsenlehner U, Thurner EM et al (2014) The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients. Br J Cancer 110:2524–2530CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Ozawa T, Ishihara S, Nishikawa T et al (2015) The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer. Int J Colorectal Dis 30:1165–1171CrossRefPubMed Ozawa T, Ishihara S, Nishikawa T et al (2015) The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer. Int J Colorectal Dis 30:1165–1171CrossRefPubMed
20.
Zurück zum Zitat Kara M, Uysal S, Altinisik U, Cevizci S, Guclu O, Derekoy FS.(2017) The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 274:535–542CrossRefPubMed Kara M, Uysal S, Altinisik U, Cevizci S, Guclu O, Derekoy FS.(2017) The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 274:535–542CrossRefPubMed
21.
Zurück zum Zitat Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471–1474CrossRefPubMed Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471–1474CrossRefPubMed
22.
Zurück zum Zitat Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10:7252–7259CrossRefPubMed Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10:7252–7259CrossRefPubMed
23.
Zurück zum Zitat Fu Y, Liu W, OuYang D, Yang A, Zhang Q (2016) Preoperative neutrophil-to-lymphocyte ratio predicts long-term survival in patients undergoing total laryngectomy with advanced laryngeal squamous cell carcinoma: a single-center retrospective study. Medicine 95:e2689CrossRefPubMedPubMedCentral Fu Y, Liu W, OuYang D, Yang A, Zhang Q (2016) Preoperative neutrophil-to-lymphocyte ratio predicts long-term survival in patients undergoing total laryngectomy with advanced laryngeal squamous cell carcinoma: a single-center retrospective study. Medicine 95:e2689CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Fu Y, Mao Y, Chen S, Yang A, Zhang Q (2016) A novel inflammation- and nutrition-based prognostic system for patients with laryngeal squamous cell carcinoma: combination of red blood cell distribution width and body mass index (COR-BMI). PLoS One 11:e0163282CrossRefPubMedPubMedCentral Fu Y, Mao Y, Chen S, Yang A, Zhang Q (2016) A novel inflammation- and nutrition-based prognostic system for patients with laryngeal squamous cell carcinoma: combination of red blood cell distribution width and body mass index (COR-BMI). PLoS One 11:e0163282CrossRefPubMedPubMedCentral
25.
27.
Zurück zum Zitat Silvis SE, Turkbas N, Doscherholmen A (1970) Thrombocytosis in patients with lung cancer. JAMA 211:1852–1853CrossRefPubMed Silvis SE, Turkbas N, Doscherholmen A (1970) Thrombocytosis in patients with lung cancer. JAMA 211:1852–1853CrossRefPubMed
28.
Zurück zum Zitat Takahashi Y, Bucana CD, Akagi Y et al. (1998) Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin Cancer Res 4:429–434PubMed Takahashi Y, Bucana CD, Akagi Y et al. (1998) Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin Cancer Res 4:429–434PubMed
29.
Zurück zum Zitat Gislason T, Nou E (1985) Sedimentation rate, leucocytes, platelet count and haemoglobin in bronchial carcinoma: an epidemiological study. Eur J Respirat Di 66:141–146 Gislason T, Nou E (1985) Sedimentation rate, leucocytes, platelet count and haemoglobin in bronchial carcinoma: an epidemiological study. Eur J Respirat Di 66:141–146
30.
Zurück zum Zitat el-Hag A, Clark RA (1987) Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol 139:2406–2413PubMed el-Hag A, Clark RA (1987) Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol 139:2406–2413PubMed
31.
Zurück zum Zitat Wu G, Yao Y, Bai C et al. (2015) Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients. Thoracic cancer 6:275–287CrossRefPubMedPubMedCentral Wu G, Yao Y, Bai C et al. (2015) Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients. Thoracic cancer 6:275–287CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Feng JF, Huang Y, Liu JS (2013) Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. OncoTargets Ther 6:1605–1612 Feng JF, Huang Y, Liu JS (2013) Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. OncoTargets Ther 6:1605–1612
33.
Zurück zum Zitat Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A (2013) The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma. J Surg Oncol 108:481–485CrossRefPubMed Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A (2013) The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma. J Surg Oncol 108:481–485CrossRefPubMed
34.
Zurück zum Zitat Nagaoka S, Yoshida T, Akiyoshi J et al (2007) Serum C-reactive protein levels predict survival in hepatocellular carcinoma. Liver Int 27:1091–1097CrossRefPubMed Nagaoka S, Yoshida T, Akiyoshi J et al (2007) Serum C-reactive protein levels predict survival in hepatocellular carcinoma. Liver Int 27:1091–1097CrossRefPubMed
35.
Zurück zum Zitat Yalcinkaya E, Bugan B, Celik M, Yasar S, Gursoy E (2013) Neutrophil lymphocyte ratio should be assessed together with other inflammatory markers and confounding factors. Eur Rev Med Pharmacol Sci 17:2410PubMed Yalcinkaya E, Bugan B, Celik M, Yasar S, Gursoy E (2013) Neutrophil lymphocyte ratio should be assessed together with other inflammatory markers and confounding factors. Eur Rev Med Pharmacol Sci 17:2410PubMed
Metadaten
Titel
Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer
verfasst von
Yize Mao
Yan Fu
Yunfei Gao
Ankui Yang
Quan Zhang
Publikationsdatum
23.12.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 2/2018
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-017-4849-4

Weitere Artikel der Ausgabe 2/2018

European Archives of Oto-Rhino-Laryngology 2/2018 Zur Ausgabe

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.