The authors declare that they have no competing interests.
OGR collected the material, carried out immunohistochemical and immunofluorescence staining, interpreted data, performed statistical analysis, and drafted the manuscript. SNM carried out immunohistochemical staining, interpreted data and drafted the manuscript. Gs and EHO participated in the design of the study, contributed to interpretation of data, and critically revised the manuscript. LUH conceived the design of the study, contributed to interpretation of data, and critically revised the manuscript. SES participated in the design of the study, contributed to interpretation of data, performed statistical analysis, and revised the manuscript critically. All authors read and approved the final manuscript.
Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers. Thus, to optimize treatment for the individual patient, there is a need for biomarkers that can predict tumor behavior.
In the present study the potential prognostic value of plectin was evaluated by a tissue microarray (TMA) based immunohistochemical analysis of primary tumor tissue obtained from a North Norwegian cohort of 115 patients diagnosed with OSCC. The expression of plectin was compared with clinicopathological variables and 5 year survival.
The statistical analysis revealed that low expression of plectin in the tumor cells predicted a favorable outcome for patients with non-metastatic disease (p = 0.008). Furthermore, the expression of plectin was found to correlate (p = 0.01) with the expression of uPAR, which we have previously found to be a potential prognostic marker for T1N0 tumors.
Our results indicate that low expression of plectin predicts a favorable outcome for patients with non-metastatic OSCC and the expression level of plectin may therefore be used in the treatment stratification for patients with early stage disease.
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- Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
Oddveig G. Rikardsen
Synnøve N. Magnussen
Sonja E. Steigen
- BioMed Central
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