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Breast Cancer Research

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01.05.2010 | Poster presentation

PLU-1/Jarid1B contributes to estrogen-induced cell proliferation in the normal mammary gland and in breast cancer, and is required for embryonic survival

verfasst von: S Catchpole, B Spencer-Dene, D Hall, A Scibetta, J Burchell, J Taylor-Papadimitriou

Erschienen in: Breast Cancer Research | Sonderheft 1/2010

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Excerpt

PLU-1/Jarid1B is a nuclear protein that is widely expressed in breast cancer, with higher levels being seen in ER⁺ cancers. Expression in normal adult issues is largely restricted to testis and the differentiating mammary gland. Through the JmjC domain the protein can demethylate H3K4me3, which correlates with its function as a transcriptional repressor. PLU-1/Jarid1B contains a DNA binding domain, and can be recruited to DNA through binding to transcription factors. We now find that the protein interacts with the ERα receptor and contributes to estrogen-induced survival of MCF-7 cells in in vitro culture and when grown as tumours in nude mice. …

Titel: PLU-1/Jarid1B contributes to estrogen-induced cell proliferation in the normal mammary gland and in breast cancer, and is required for embryonic survival
verfasst von: S Catchpole
B Spencer-Dene
D Hall
A Scibetta
J Burchell
J Taylor-Papadimitriou
Publikationsdatum: 01.05.2010
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 1/2010
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2514

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PLU-1/Jarid1B contributes to estrogen-induced cell proliferation in the normal mammary gland and in breast cancer, and is required for embryonic survival

Excerpt

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