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01.06.2014 | Glaucoma | Ausgabe 6/2014

Graefe's Archive for Clinical and Experimental Ophthalmology 6/2014

Pneumatic trabecular bypass versus trabeculotomy in the management of primary congenital glaucoma

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 6/2014
Autor:
Mohamed A. Eldaly
Wichtige Hinweise

Contribution

Conceiving and designing research protocol and electronic database template, operation and organising follow-up of the cases, analysis and interpretation of data; drafting the article and revising it critically for important intellectual content; and final approval of the version to be published.

Abstract

Background

The optimal surgical management in primary congenital glaucoma (PCG) remains a subject of debate. The aim of this study was to assess efficacy of pneumatic trabecular bypass (PTB) in comparison to conventional trabeculotomy (T) in the treatment of PCG.

Methods

In a prospective comparative experimental study, one eye per child suffering from PCG underwent either PTB or T. Complete examinations were performed before surgery, postoperatively at one and seven days, then monthly for a minimum of six months. The main outcome measures were the IOP, number of IOP-lowering medications, change in cup/disc ratio, and corneal clarity.

Results

Seventeen eyes (patients) were operated on for PTB compared to 25 eyes (patients) in the T group. The mean (±SD, range) preoperative IOP in the PTB and T groups was 34.7 (6.4, 26–48) mmHg and 26.4 (6.6, 18–44) mmHg, respectively, and these dropped at six months of follow-up to 14.9 (3.6, 11–24) mmHg and 18.8 (8.0, 6–34) mmHg, respectively. The mean reductions of IOP were 55.87 %(±11) and 28.4 %(±28.8), (p = 0.001), where those for cup/disc ratio were 39.0 %(±29) and 17.5 %(±39.7) (p = 0.088) in the PTB and T groups, respectively. The number of IOP-lowering medications had dropped from 1.7 ± 0.5 to 0.7 ± 1.0 in PTB patients, compared to an insignificant change in the T group (0.64 ± 0.9 & 0.62 ± 0.9 pre- and post-operatively respectively). Corneal clarity improved in 13 eyes (76.5 %) in the PTB group, while three eyes (12 %) had worsened in the T group. Total cumulative chances for success were 88.2 % (15 out of 17 eyes), compared to 56 % (14 out of 25 eyes), in the PTB and T groups, respectively (p = 0.027).

Conclusions

PTB is a promising surgical technique for the control of primary congenital glaucoma. A randomized controlled trial with a longer follow-up is recommended.

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Literatur
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