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19.12.2019 | Original Article

Point shear wave elastography predicts fibrosis severity and steatohepatitis in alcohol-related liver disease

verfasst von: Yuri Cho, Youn I. Choi, Sohee Oh, Jimin Han, Sae Kyung Joo, Dong Hyeon Lee, Yong Jin Jung, Byeong Gwan Kim, Kook Lae Lee, Won Kim

Erschienen in: Hepatology International | Ausgabe 2/2020

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Abstract

Background

Point shear wave elastography (pSWE) is a convenient noninvasive tool for assessing liver fibrosis in chronic liver disease. However, there is little information on the correlation between pSWE and the histological findings of alcohol-related liver disease (ALD). Thus, we investigated the diagnostic performance of pSWE in discriminating the fibrosis stage of patients with ALD.

Methods

A total of 251 Korean patients with ALD were prospectively enrolled. The diagnostic performance of pSWE was evaluated on the basis of histological fibrosis severity according to Kleiner/Brunt et al.’s criteria and the Laennec classification.

Results

Median liver stiffness on pSWE significantly increased as liver fibrosis stage increased (p < 0.001). Liver stiffness measurement proved to be an excellent diagnostic indicator in the evaluation of a ≥ F2 stage (area under the receiver operating characteristics curve [AUROC] 0.93; cutoff > 1.46 m/s), ≥ F3 stage (AUROC 0.90; cutoff > 1.47 m/s), and F4 stage (AUROC 0.91; cutoff > 1.66 m/s). Compared with noninvasive serum fibrosis tests, pSWE had the highest AUROC for predicting ≥ F2, ≥ F3, and = F4 stages and the highest Obuchowski index (0.931 ± 0.007; all p < 0.001). The AUROC for discriminating steatohepatitis from simple steatosis was 0.93 (> 1.49 m/s) and the AUROC for discriminating cirrhosis with steatohepatitis from cirrhosis without steatohepatitis was 0.92 (> 2.52 m/s).

Conclusion

pSWE not only gives an accurate indication of liver fibrosis stage in ALD, but also can allow patients with severe alcoholic steatohepatitis to begin corticosteroid treatment without exposing them to the risks of liver biopsy.

Clinical trial registration

Clincialtrials.gov Identifier NCT01943318.

Graphic abstract

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Metadaten
Titel
Point shear wave elastography predicts fibrosis severity and steatohepatitis in alcohol-related liver disease
verfasst von
Yuri Cho
Youn I. Choi
Sohee Oh
Jimin Han
Sae Kyung Joo
Dong Hyeon Lee
Yong Jin Jung
Byeong Gwan Kim
Kook Lae Lee
Won Kim
Publikationsdatum
19.12.2019
Verlag
Springer India
Erschienen in
Hepatology International / Ausgabe 2/2020
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-019-10009-w

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