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Erschienen in: Journal of Assisted Reproduction and Genetics 1/2018

27.09.2017 | Review

Polycystic ovary syndrome throughout a woman’s life

verfasst von: José Bellver, Luis Rodríguez-Tabernero, Ana Robles, Elkin Muñoz, Francisca Martínez, José Landeras, Juan García-Velasco, Juan Fontes, Mónica Álvarez, Claudio Álvarez, Belén Acevedo, Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF)

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 1/2018

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Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age. Menstrual and fertility problems evolve into metabolic complications as age advances. An early and precise diagnosis is important for an adequate management of PCOS, especially at the extreme ends of the reproductive lifespan. However, many different phenotypes are included under the same condition, being important to look at these different phenotypes separately, as they may require different treatments and have different consequences. In this way, PCOS exhibits a great metabolic complexity and its diagnosis needs to be revised once again and adapted to recent data obtained by new technologies. According to the current medical literature, lifestyle therapy constitutes the first step in the management, especially when excess body weight is associated. Pharmacotherapy is frequently used to treat the most predominant manifestations in each age group, such as irregular menses and hirsutism in adolescence, fertility problems in adulthood, and metabolic problems and risk of cancer in old age. Close surveillance is mandatory in each stage of life to avoid health risks which may also affect the offspring, since fetal and post-natal complications seem to be increased in PCOS women.
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Metadaten
Titel
Polycystic ovary syndrome throughout a woman’s life
verfasst von
José Bellver
Luis Rodríguez-Tabernero
Ana Robles
Elkin Muñoz
Francisca Martínez
José Landeras
Juan García-Velasco
Juan Fontes
Mónica Álvarez
Claudio Álvarez
Belén Acevedo
Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF)
Publikationsdatum
27.09.2017
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 1/2018
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-017-1047-7

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