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Archives of Virology

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21.04.2016 | Brief Report

Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus

verfasst von: Carlos A. Pujol, Claudia S. Sepúlveda, Victoria Richmond, Marta S. Maier, Elsa B. Damonte

Erschienen in: Archives of Virology | Ausgabe 7/2016

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Abstract

Twelve polyhydroxylated sulfated steroids synthesized from a 5α-cholestane skeleton with different substitutions in C-2, C-3 and C-6 were evaluated for cytotoxicity and antiviral activity against herpes simplex virus (HSV) by a virus plaque reduction assay. Four compounds elicited a selective inhibitory effect against HSV. The disodium salt of 2β,3α-dihydroxy-6E-hydroximine-5α-cholestane-2,3-disulfate, named compound 7, was the most effective inhibitor of HSV-1, HSV-2 and pseudorabies virus (PrV) strains, including acyclovir-resistant variants, in human and monkey cell lines. Preliminary mechanistic studies demonstrated that compound 7 did not affect the initial steps of virus entry but inhibited a subsequent event in the infection process of HSV.

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Titel: Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus
verfasst von: Carlos A. Pujol
Claudia S. Sepúlveda
Victoria Richmond
Marta S. Maier
Elsa B. Damonte
Publikationsdatum: 21.04.2016
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 7/2016
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-2867-y

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Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus

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