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Immunologic Research
Erschienen in: Immunologic Research 4/2017

24.07.2017 | Review

Polymorphisms in miRNA genes and their involvement in autoimmune diseases susceptibility

verfasst von: Andrea Latini, Cinzia Ciccacci, Giuseppe Novelli, Paola Borgiani

Erschienen in: Immunologic Research | Ausgabe 4/2017

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Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate the expression of multiple protein-encoding genes at the post-transcriptional level. MicroRNAs are involved in different pathways, such as cellular proliferation and differentiation, signal transduction and inflammation, and play crucial roles in the development of several diseases, such as cancer, diabetes, and cardiovascular diseases. They have recently been recognized to play a role also in the pathogenesis of autoimmune diseases. Although the majority of studies are focused on miRNA expression profiles investigation, a growing number of studies have been investigating the role of polymorphisms in miRNA genes in the autoimmune diseases development. Indeed, polymorphisms affecting the miRNA genes can modify the set of targets they regulate or the maturation efficiency. This review is aimed to give an overview about the available studies that have investigated the association of miRNA gene polymorphisms with the susceptibility to various autoimmune diseases and to their clinical phenotypes.
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Metadaten
Titel
Polymorphisms in miRNA genes and their involvement in autoimmune diseases susceptibility
verfasst von
Andrea Latini
Cinzia Ciccacci
Giuseppe Novelli
Paola Borgiani
Publikationsdatum
24.07.2017
Verlag
Springer US
Erschienen in
Immunologic Research / Ausgabe 4/2017
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-017-8937-8

Weitere Artikel der Ausgabe 4/2017

Immunologic Research 4/2017 Zur Ausgabe

Original Article

The levels of DNGR-1 and its ligand-bearing cells were altered after human and simian immunodeficiency virus infection

Original Article

Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response

Original Article

The NLRP3 and CASP1 gene polymorphisms are associated with developing of acute coronary syndrome: a case-control study

Original Article

Effector functions of memory CTLs can be affected by signals received during reactivation

Original Article

miR-451 limits CD4+ T cell proliferative responses to infection in mice

Original Article

Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-α: a randomized placebo-controlled double-blind clinical trial

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