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Erschienen in: Breast Cancer Research 2/2005

01.06.2005 | Poster Presentation

Polymorphisms in the CRK gene and their association with breast cancer risk

verfasst von: K Wagner, K Hemminki, E Grzybowska, A Försti

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

Recent findings suggest an important influence of the GH1/IGF1 axis in the development of breast cancer. By binding to its receptor, IGF-1 stimulates numerous downstream signaling proteins resulting in the regulation of cell proliferation, differentiation and apoptosis [1]. One member of this pathway is CRK (v-crk sarcoma virus CT10 oncogene homolog), which is tyrosine phosphorylated upon IGF-1 stimulation. CRK has been found to be overexpressed in various human tumor tissues and cell lines [2]. However, little is known about alterations in the genomic sequence of this gene. …
Literatur
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Zurück zum Zitat Laban C, Bustin SA, Jenkins PJ: The GH-IGF-I axis and breast cancer. Trends Endocrinol Metab. 2003, 14: 28-34. 10.1016/S1043-2760(02)00003-6.CrossRefPubMed Laban C, Bustin SA, Jenkins PJ: The GH-IGF-I axis and breast cancer. Trends Endocrinol Metab. 2003, 14: 28-34. 10.1016/S1043-2760(02)00003-6.CrossRefPubMed
2.
Zurück zum Zitat Nishihara H, Tanaka S, Tsuda M, Oikawa S, Maeda M, Shimizu M, Shinomiya H, Tanigami A, Sawa H, Nagashima K: Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. Cancer Lett. 2002, 180: 55-61. 10.1016/S0304-3835(01)00763-7.CrossRefPubMed Nishihara H, Tanaka S, Tsuda M, Oikawa S, Maeda M, Shimizu M, Shinomiya H, Tanigami A, Sawa H, Nagashima K: Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. Cancer Lett. 2002, 180: 55-61. 10.1016/S0304-3835(01)00763-7.CrossRefPubMed
Metadaten
Titel
Polymorphisms in the CRK gene and their association with breast cancer risk
verfasst von
K Wagner
K Hemminki
E Grzybowska
A Försti
Publikationsdatum
01.06.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1108

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