Erschienen in:
01.06.2005 | Poster Presentation
Polymorphisms in the CRK gene and their association with breast cancer risk
verfasst von:
K Wagner, K Hemminki, E Grzybowska, A Försti
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
Recent findings suggest an important influence of the GH1/IGF1 axis in the development of breast cancer. By binding to its receptor, IGF-1 stimulates numerous downstream signaling proteins resulting in the regulation of cell proliferation, differentiation and apoptosis [
1]. One member of this pathway is CRK (v-crk sarcoma virus CT10 oncogene homolog), which is tyrosine phosphorylated upon IGF-1 stimulation. CRK has been found to be overexpressed in various human tumor tissues and cell lines [
2]. However, little is known about alterations in the genomic sequence of this gene. …