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Erschienen in: Sleep and Breathing 1/2021

25.03.2020 | Sleep Breathing Physiology and Disorders • Original Article

Polysomnographic risk factors for vigilance-related cognitive decline and obstructive sleep apnea

verfasst von: Karen McCloy, Brett Duce, Vinayak Swarnkar, Craig Hukins, Udantha Abeyratne

Erschienen in: Sleep and Breathing | Ausgabe 1/2021

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Abstract

Purpose

Cognitive decline (CD) and obstructive sleep apnea (OSA) are often comorbid. Some modifiable risk factors (RF) for CD are also associated with OSA. Diagnostic polysomnography (PSG) measures these RF and may identify at risk patients prior to the onset of CD. We aim to determine whether there are severe RF associated with established CD and an increasing severity of OSA that could identify patients at risk for CD for medical intervention.

Methods

We gathered information from subjects having type 1 PSG for suspected OSA. The psychomotor vigilance task (PVT) measured established CD (group 0 and group1). We compared levels of severe RF in group 0 and group 1 with a larger group (group 2) without the PVT. We used severe standardized values of excessive daytime sleepiness (Epworth Sleepiness Score [ESS]), overnight change of systolic blood pressure (ΔSBP), change of oxygen desaturation (ΔSpO2), and sleep arousal (ArI) as RF. We compared the severe levels of ESS, ΔSBP, ΔSpO2, and ArI by group and OSA severity.

Results

A total of 136 patients underwent diagnostic PSG. PVT parameters were available for 43 subjects. The severity of the RF was consistent with risk for CD (ΔSBP 22.0 ± 5.6, ESS 18.2 ± 2.2, ArI 58.8 ± 18.7, ΔSpO2 61.7 ± 21.9). The levels of RF increased with increasing severity of OSA. There were significant between-group differences for severe ΔSpO2 (p = 0.004) and ΔSpO2 + ArI (p = 0.019).

Conclusion

The levels of RF increase with increasing OSA severity. Subjects with severe RF ΔSpO2 and ΔSpO2 + ArI are likely to have PVT-determined CD. Risk factor analysis may screen for CD.
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Metadaten
Titel
Polysomnographic risk factors for vigilance-related cognitive decline and obstructive sleep apnea
verfasst von
Karen McCloy
Brett Duce
Vinayak Swarnkar
Craig Hukins
Udantha Abeyratne
Publikationsdatum
25.03.2020
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 1/2021
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-020-02050-z

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