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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Pulmonary Medicine 1/2015

Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension

Zeitschrift:
BMC Pulmonary Medicine > Ausgabe 1/2015
Autoren:
Henning Tiede, Janet Rorzyczka, Rio Dumitrascu, Michael Belly, Frank Reichenberger, Hossein Ardeschir Ghofrani, Werner Seeger, Jörg Heitmann, Richard Schulz
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12890-015-0005-3) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

HT was involved in the design and conduct of the study, performed the statistical analysis and wrote the manuscript. JR, RD and MB made significant contributions to data collection and analysis. FR, HAG, WS and JH helped to build up the study design and analyse/interpret the data. RS conceived and coordinated the study and was responsible for final data analysis/interpretation and drafting of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated.

Methods

Clinically stable out-patients with idiopathic pulmonary arterial hypertension (IPAH, n = 52) and chronic thromboembolic PH (CTEPH, n = 64) in NYHA classes II and III were prospectively enrolled. 54 healthy volunteers matched for anthropometric variables served as a control group. The Pittsburgh Sleep Quality Index (PSQI) was used to rate subjective sleep quality. In the PH patients, six-minute walk tests (6MWT) were performed to assess exercise capacity.

Results

Poor sleep quality (i.e. a PSQI score > 5) occurred more frequently in PH (IPAH: n = 25 [48.1%], CTEPH: n = 39 [60.9%], controls: n = 10 [18.5%]; p < 0.01 when compared to controls). In addition, poor vs. good sleepers had significantly higher average NYHA class (IPAH: 2.6 ± 0.1 vs. 2.3 ± 0.1, CTEPH: 2.8 ± 0.1 vs. 2.3 ± 0.2; p < 0.01) and shorter 6MWT distances (IPAH: 338 ± 23 vs. 441 ± 29 m, CTEPH: 355 ± 15 vs. 413 ± 26 m; p < 0.05).

Conclusions

Self-reported poor sleep quality is more common in PH than in healthy controls. Furthermore, it is related to reduced physical exercise capacity.
Zusatzmaterial
Additional file 1: Pittsburgh sleep quality index.
12890_2015_5_MOESM1_ESM.pdf
Additional file 2: Epworth sleepiness scale.
12890_2015_5_MOESM2_ESM.doc
Literatur
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