T.M. received research funds from MSD, Takeda and Eli Lilly. and received research grand from Manpei Suzuki Diabetes Foundation. T.O. had received lecture fees from Boehringer Ingelheim, Sanofi-Aventis, Ono Pharmaceutical Co., Novo Nordisk Pharma, Kissei Pharma, Mitsubishi Tanabe Pharma, Novartis Pharmaceuticals, Sanwakagaku Kenkyusho, Daiichi Sankyo Inc., Takeda Pharmaceutical Co., MSD, Dainippon Sumitomo Pharm., Kowa Co. and research funds from Novo Nordisk Pharma, Dainippon Sumitomo Pharma. A.K. had received lecture fees from Kissei Pharma, Sanofi-Aventis and Takeda Pharmaceutical Co. M.G. had received lecture fee from Novartis Pharmaceuticals. Y.F. had received lecture fees from Novartis Pharmaceuticals and Eli Lilly, research funds from Novartis Pharmaceuticals , MSD and Takeda Pharmaceutical Co. H.W. had received lecture fees from Asteras, Astrazeneca, Boehringer Ingelheim, Daiichi Sankyo Inc., Eli Lilly and Company, Kissei Pharmaceutical Co., Kowa Pharmaceutical CO., Kyowa Hakko Kirin Co., MSD, Novartis Pharmaceuticals, Novo Nordisk Pharma, Ono Pharmaceutical Co., Mitsubishi Tanabe Pharma, Sanofi-Aventis, Sanwakagaku Kenkyusho, and Takeda Pharmaceutical Co., and research funds from Asteras, Astrazeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo Inc., Dainippon Sumitomo Pharma, Eli Lilly, Johnson and Johnson, Kissei Pharmaceutical Co., Kowa Pharmaceutical CO., Kyowa Hakko Kirin Co. MSD, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical Co., Novartis Pharmaceuticals, Novo Nordisk Pharma, Pfizer, Sanwakagaku Kenkyusho, Sanofi-Aventis, and Takeda Pharmaceutical Co..
All authors contributed to the study design and were involved at all stages of manuscript development. Y.O. and T.M. mainly drafted the manuscript. M.G., a biostatistician, contributed to data analysis. All authors were involved in analysis and interpretation of data, reviewed/edited the manuscript and approved the final manuscript. H.W. is the principal guarantor of this work and has full access to all the data in the study and takes responsibility for the integrity of the data and accuracy of data analysis. All authors read and approved the final manuscript.
While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship.
The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated.
The mean PSQI was 5.1 ± 3.0 (±SD). Patients were divided into three groups based on the total PSQI score; subjects with good sleep quality (n = 462), average sleep quality (n = 185), and poor sleep quality (n = 77). In the age/gender-adjusted model, patients with poor sleep quality tended to be obese, evening type and depressed. However, other lifestyles showed no significant trends. Alanine aminotransferase, fasting blood glucose, HbA1c, systolic blood pressure, urinary albumin excretion, and brachial-ankle pulse wave velocity (baPWV) tended to be higher in patients with poor sleep quality. High baPWV was the only parameter that correlated with poor sleep in a model adjusted for several other lifestyle factors.
Our study indicates that poor sleep quality in T2DM patients correlates with increased arterial wall stiffness, a marker of atherosclerosis and a risk factor for cardiovascular diseases.
Miyano I, Nishinaga M, Takata J, Shimizu Y, Okumiya K, Matsubayashi K, Ozawa T, Sugiura T, Yasuda N, Doi Y. Association between brachial-ankle pulse wave velocity and 3-year mortality in community-dwelling older adults. Hypertens Res. 2010;33(7):678–82.
Maeda Y, Inoguchi T, Etoh E, Kodama Y, Sasaki S, Sonoda N, Nawata H, Shimabukuro M, Takayanagi R. Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: the Kyushu prevention study for atherosclerosis. Diabetes care 2014;25(3):359–64.
Osonoi Y, Mita T, Osonoi T, Saito M, Tamasawa A, Nakayama S, Someya Y, Ishida H, Kanazawa A, Gosho A, et al. Morningness Eveningness Questionnaire score and metabolic parameters in patients with type 2 diabetes mellitus. Chronobiol Int. Chronobiol Int. 2014 31(9):1017–23.
Hone JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4:97–110.
Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation; 1996.
Agency SaT. Standard tables of food composition in Japan (in Japanese). 5th ed. Tokyo: Printing Bureau of the Ministry of Finance; 2005.
- Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II