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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Yusuke Osonoi, Tomoya Mita, Takeshi Osonoi, Miyoko Saito, Atsuko Tamasawa, Shiho Nakayama, Yuki Someya, Hidenori Ishida, Akio Kanazawa, Masahiko Gosho, Yoshio Fujitani, Hirotaka Watada
Wichtige Hinweise

Competing interests

T.M. received research funds from MSD, Takeda and Eli Lilly. and received research grand from Manpei Suzuki Diabetes Foundation. T.O. had received lecture fees from Boehringer Ingelheim, Sanofi-Aventis, Ono Pharmaceutical Co., Novo Nordisk Pharma, Kissei Pharma, Mitsubishi Tanabe Pharma, Novartis Pharmaceuticals, Sanwakagaku Kenkyusho, Daiichi Sankyo Inc., Takeda Pharmaceutical Co., MSD, Dainippon Sumitomo Pharm., Kowa Co. and research funds from Novo Nordisk Pharma, Dainippon Sumitomo Pharma. A.K. had received lecture fees from Kissei Pharma, Sanofi-Aventis and Takeda Pharmaceutical Co. M.G. had received lecture fee from Novartis Pharmaceuticals. Y.F. had received lecture fees from Novartis Pharmaceuticals and Eli Lilly, research funds from Novartis Pharmaceuticals , MSD and Takeda Pharmaceutical Co. H.W. had received lecture fees from Asteras, Astrazeneca, Boehringer Ingelheim, Daiichi Sankyo Inc., Eli Lilly and Company, Kissei Pharmaceutical Co., Kowa Pharmaceutical CO., Kyowa Hakko Kirin Co., MSD, Novartis Pharmaceuticals, Novo Nordisk Pharma, Ono Pharmaceutical Co., Mitsubishi Tanabe Pharma, Sanofi-Aventis, Sanwakagaku Kenkyusho, and Takeda Pharmaceutical Co., and research funds from Asteras, Astrazeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo Inc., Dainippon Sumitomo Pharma, Eli Lilly, Johnson and Johnson, Kissei Pharmaceutical Co., Kowa Pharmaceutical CO., Kyowa Hakko Kirin Co. MSD, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical Co., Novartis Pharmaceuticals, Novo Nordisk Pharma, Pfizer, Sanwakagaku Kenkyusho, Sanofi-Aventis, and Takeda Pharmaceutical Co..

Authors’ contributions

All authors contributed to the study design and were involved at all stages of manuscript development. Y.O. and T.M. mainly drafted the manuscript. M.G., a biostatistician, contributed to data analysis. All authors were involved in analysis and interpretation of data, reviewed/edited the manuscript and approved the final manuscript. H.W. is the principal guarantor of this work and has full access to all the data in the study and takes responsibility for the integrity of the data and accuracy of data analysis. All authors read and approved the final manuscript.

Abstract

Background

While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship.

Methods

The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated.

Results

The mean PSQI was 5.1 ± 3.0 (±SD). Patients were divided into three groups based on the total PSQI score; subjects with good sleep quality (n = 462), average sleep quality (n = 185), and poor sleep quality (n = 77). In the age/gender-adjusted model, patients with poor sleep quality tended to be obese, evening type and depressed. However, other lifestyles showed no significant trends. Alanine aminotransferase, fasting blood glucose, HbA1c, systolic blood pressure, urinary albumin excretion, and brachial-ankle pulse wave velocity (baPWV) tended to be higher in patients with poor sleep quality. High baPWV was the only parameter that correlated with poor sleep in a model adjusted for several other lifestyle factors.

Conclusions

Our study indicates that poor sleep quality in T2DM patients correlates with increased arterial wall stiffness, a marker of atherosclerosis and a risk factor for cardiovascular diseases.
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