The online version of this article (doi:10.1007/s10552-016-0797-3) contains supplementary material, which is available to authorized users.
Epidemiological evidence suggests a role for an infectious etiology for cancers in teenagers and young adults (TYAs). We investigated this by describing associations between infection transmission using the population mixing (PM) proxy and incidence of cancers in TYAs in Yorkshire, UK.
We extracted cancer cases from the Yorkshire Specialist Register of Cancer in Children and Young People from 1990 to 2013 (n = 1929). Using multivariable Poisson regression models (adjusting for effects of deprivation and population density), we investigated whether PM was associated with cancer incidence. We included population mixing–population density interaction terms to examine for differences in effects of PM in urban and rural populations.
Nonsignificant IRRs were observed for leukemias (IRR 1.20, 95% CI 0.91–1.59), lymphomas (IRR 1.09, 95% CI 0.90–1.32), central nervous system tumors (IRR 1.06, 95% CI 0.80–1.40) and germ cell tumors (IRR 1.14, 95% CI 0.92–1.41). The association between PM and cancer incidence did not vary in urban and rural areas.
Study results suggest PM is not associated with incidence of cancers among TYAs. This effect does not differ between rural and urban settings.
Supplementary material 1 (DOCX 17 kb)10552_2016_797_MOESM1_ESM.docx
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- Population mixing and incidence of cancers in adolescents and young adults between 1990 and 2013 in Yorkshire, UK
R. C. Parslow
R. G. Feltbower
- Springer International Publishing
Neu im Fachgebiet Onkologie
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