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Archives of Virology

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02.01.2017 | Brief Report

Porcine mast cells infected with H1N1 influenza virus release histamine and inflammatory cytokines and chemokines

verfasst von: In Hong Lee, Hyun Soo Kim, Sang Heui Seo

Erschienen in: Archives of Virology | Ausgabe 4/2017

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Abstract

Mast cells reside in many tissues, including the lungs, and might play a role in enhancing influenza virus infections in animals. In this study, we cultured porcine mast cells from porcine bone marrow cells with IL-3 and stem cell factor to study the infectivity and activation of the 2009 pandemic H1N1 influenza virus of swine origin. Porcine mast cells were infected with H1N1 influenza virus, without the subsequent production of infectious viruses but were activated, as indicated by the release of histamines. Inflammatory cytokine- and chemokine-encoding genes, including IL-1α, IL-6, CXCL9, CXCL10, and CXCL11, were upregulated in the infected porcine mast cells. Our results suggest that mast cells could be involved in enhancing influenza-virus-mediated disease in infected animals.

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Titel: Porcine mast cells infected with H1N1 influenza virus release histamine and inflammatory cytokines and chemokines
verfasst von: In Hong Lee
Hyun Soo Kim
Sang Heui Seo
Publikationsdatum: 02.01.2017
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 4/2017
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-3216-x

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Porcine mast cells infected with H1N1 influenza virus release histamine and inflammatory cytokines and chemokines

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