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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 9/2019

11.06.2019 | Original Article

Portraying infective endocarditis: results of multinational ID-IRI study

verfasst von: Hakan Erdem, Edmond Puca, Yvon Ruch, Lurdes Santos, Nesrin Ghanem-Zoubi, Xavier Argemi, Yves Hansmann, Rahmet Guner, Gilda Tonziello, Jean-Philippe Mazzucotelli, Najada Como, Sukran Kose, Ayse Batirel, Asuman Inan, Necla Tulek, Abdullah Umut Pekok, Ejaz Ahmed Khan, Atilla Iyisoy, Meliha Meric-Koc, Ayse Kaya-Kalem, Pedro Palma Martins, Imran Hasanoglu, André Silva-Pinto, Nefise Oztoprak, Raquel Duro, Fahad Almajid, Mustafa Dogan, Nicolas Dauby, Jesper Damsgaard Gunst, Recep Tekin, Deborah Konopnicki, Nicola Petrosillo, Ilkay Bozkurt, Jamal Wadi, Corneliu Popescu, Ilker Inanc Balkan, Safak Ozer-Balin, Tatjana Lejko Zupanc, Antonio Cascio, Irina Magdalena Dumitru, Aysegul Erdem, Gulden Ersoz, Meltem Tasbakan, Oday Abu Ajamieh, Fatma Sirmatel, Simin Florescu, Serda Gulsun, Hacer Deniz Ozkaya, Sema Sari, Selma Tosun, Meltem Avci, Yasemin Cag, Guven Celebi, Ayse Sagmak-Tartar, Sumeyra Karakus, Alper Sener, Arjeta Dedej, Serkan Oncu, Rosa Fontana Del Vecchio, Derya Ozturk-Engin, Canan Agalar

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2019

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Abstract

Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
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Metadaten
Titel
Portraying infective endocarditis: results of multinational ID-IRI study
verfasst von
Hakan Erdem
Edmond Puca
Yvon Ruch
Lurdes Santos
Nesrin Ghanem-Zoubi
Xavier Argemi
Yves Hansmann
Rahmet Guner
Gilda Tonziello
Jean-Philippe Mazzucotelli
Najada Como
Sukran Kose
Ayse Batirel
Asuman Inan
Necla Tulek
Abdullah Umut Pekok
Ejaz Ahmed Khan
Atilla Iyisoy
Meliha Meric-Koc
Ayse Kaya-Kalem
Pedro Palma Martins
Imran Hasanoglu
André Silva-Pinto
Nefise Oztoprak
Raquel Duro
Fahad Almajid
Mustafa Dogan
Nicolas Dauby
Jesper Damsgaard Gunst
Recep Tekin
Deborah Konopnicki
Nicola Petrosillo
Ilkay Bozkurt
Jamal Wadi
Corneliu Popescu
Ilker Inanc Balkan
Safak Ozer-Balin
Tatjana Lejko Zupanc
Antonio Cascio
Irina Magdalena Dumitru
Aysegul Erdem
Gulden Ersoz
Meltem Tasbakan
Oday Abu Ajamieh
Fatma Sirmatel
Simin Florescu
Serda Gulsun
Hacer Deniz Ozkaya
Sema Sari
Selma Tosun
Meltem Avci
Yasemin Cag
Guven Celebi
Ayse Sagmak-Tartar
Sumeyra Karakus
Alper Sener
Arjeta Dedej
Serkan Oncu
Rosa Fontana Del Vecchio
Derya Ozturk-Engin
Canan Agalar
Publikationsdatum
11.06.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 9/2019
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-019-03607-x

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