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27.02.2019 | Review Article

Positive pressure device treatment for Menière’s disease: an overview of the current evidence and a meta-analysis

Zeitschrift:
European Archives of Oto-Rhino-Laryngology
Autoren:
Louise Devantier, Frank Liviu-Adelin Guldfred, Bjarki Ditlev Djurhuus, Mina Nicole Händel, Jesper Hvass Schmidt, Dan Dupont Hougaard, Henriette Edemann-Callesen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00405-019-05359-y) contains supplementary material, which is available to authorized users.

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Abstract

Objective

The objective was to critically assess the current evidence investigating the efficacy of using a positive pressure device in patients with definite or probable Menière’s disease.

Methods

We performed a systematic literature search in MEDLINE, EMBASE and PsycINFO up to February 2018. We included both systematic reviews and primary literature [randomized controlled trials (RCTs)] investigating positive pressure treatment, in patients (≥ 18 years of age), with Menière’s disease. We assessed the internal validity of systematic reviews using the AMSTAR tool and risk of bias of primary studies using the Cochrane Risk of bias tool. We performed a meta-analysis for each outcome based on the identified studies. The overall certainty of evidence for the outcomes was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE).

Results

The search for systematic reviews identified four relevant reviews. These all included the same four RCTs. An updated search identified one additional RCT. In total, five RCTs were included in the data synthesis. Our data synthesis showed no effect of positive pressure treatment on primary nor secondary outcomes. No serious adverse events were reported. The overall certainty of evidence ranged from very low to low, due to the serious risk of bias and imprecision.

Conclusion

The current available evidence does not support positive pressure device treatment in patients with Menière’s disease. However, the limitations of the current literature hinder the possibility of any solid conclusion. There remains a need for randomized controlled trials of high quality to fully access the utility of this treatment.

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Zusatzmaterial
Supplementary material 1 (PDF 1928 KB)
405_2019_5359_MOESM1_ESM.pdf
Literatur
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