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Erschienen in: Breast Cancer 4/2017

05.06.2017 | Special Feature

Post-mastectomy radiation therapy in breast cancer with 1–3 involved lymph nodes: the Pros

verfasst von: Keiichiro Tada, Kotoe Nishioka, Yasuko Kikuchi, Takayoshi Niwa, Yasuyuki Seto

Erschienen in: Breast Cancer | Ausgabe 4/2017

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Abstract

In 2014, the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) reported that post-mastectomy radiation therapy (PMRT) for breast cancer patients with 1–3 cancer-positive lymph nodes is associated with a survival benefit. However, it is not known whether this applies to Japanese patients in daily clinical practice, because this conclusion was based on the results of older, western trials. Therefore, we studied the differences between PMRT results in western breast cancer patients and current practice in Japanese patients. Although we identified three differences, they do not appear to strongly impact the results of EBCTCG. We conclude that Japanese breast cancer patients with 1–3 positive lymph nodes should receive PMRT in daily clinical practice.
Literatur
1.
Zurück zum Zitat Early Breast Cancer Trialists’ Collaborative Group, Peto R, Davies C, Godwin J, Gray R, Pan HC, et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012;379:432–44.CrossRef Early Breast Cancer Trialists’ Collaborative Group, Peto R, Davies C, Godwin J, Gray R, Pan HC, et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012;379:432–44.CrossRef
2.
Zurück zum Zitat Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366:2087–106.CrossRefPubMed Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366:2087–106.CrossRefPubMed
3.
Zurück zum Zitat Harris JR, Halpin-Murphy P, McNeese M, Mendenhall NP, Morrow M, Robert NJ. Consensus Statement on postmastectomy radiation therapy. Int J Radiat Oncol Biol Phys. 1999;44:989–90.CrossRefPubMed Harris JR, Halpin-Murphy P, McNeese M, Mendenhall NP, Morrow M, Robert NJ. Consensus Statement on postmastectomy radiation therapy. Int J Radiat Oncol Biol Phys. 1999;44:989–90.CrossRefPubMed
4.
Zurück zum Zitat Recht A, Edge SB, Solin LJ, Robinson DS, Estabrook A, Fine RE, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19:1539–69.CrossRefPubMed Recht A, Edge SB, Solin LJ, Robinson DS, Estabrook A, Fine RE, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19:1539–69.CrossRefPubMed
5.
Zurück zum Zitat Early Breast Cancer Trialists’ Collaborative Group, McGale P, Taylor C, Correa C, Cutter D, Duane F, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 2014;383:2127–35.CrossRef Early Breast Cancer Trialists’ Collaborative Group, McGale P, Taylor C, Correa C, Cutter D, Duane F, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 2014;383:2127–35.CrossRef
6.
Zurück zum Zitat Matsunuma R, Oguchi M, Fujikane T, Matsuura M, Sakai T, Kimura K, et al. Influence of lymphatic invasion on locoregional recurrence following mastectomy: indication for postmastectomy radiotherapy for breast cancer patients with one to three positive nodes. Int J Radiat Oncol Biol Phys. 2012;83:845–52.CrossRefPubMed Matsunuma R, Oguchi M, Fujikane T, Matsuura M, Sakai T, Kimura K, et al. Influence of lymphatic invasion on locoregional recurrence following mastectomy: indication for postmastectomy radiotherapy for breast cancer patients with one to three positive nodes. Int J Radiat Oncol Biol Phys. 2012;83:845–52.CrossRefPubMed
7.
Zurück zum Zitat Hamamoto Y, Ohsumi S, Aogi K, Shinohara S, Nakajima N, Kataoka M, et al. Are there high-risk subgroups for isolated locoregional failure in patients who had T1/2 breast cancer with one to three positive lymph nodes and received mastectomy without radiotherapy? Breast Cancer. 2014;21:177–82.CrossRefPubMed Hamamoto Y, Ohsumi S, Aogi K, Shinohara S, Nakajima N, Kataoka M, et al. Are there high-risk subgroups for isolated locoregional failure in patients who had T1/2 breast cancer with one to three positive lymph nodes and received mastectomy without radiotherapy? Breast Cancer. 2014;21:177–82.CrossRefPubMed
8.
Zurück zum Zitat Nagao T, Kinoshita T, Tamura N, Hojo T, Morota M, Kagami Y. Locoregional recurrence risk factors in breast cancer patients with positive axillary lymph nodes and the impact of postmastectomy radiotherapy. Int J Clin Oncol. 2013;18:54–61.CrossRefPubMed Nagao T, Kinoshita T, Tamura N, Hojo T, Morota M, Kagami Y. Locoregional recurrence risk factors in breast cancer patients with positive axillary lymph nodes and the impact of postmastectomy radiotherapy. Int J Clin Oncol. 2013;18:54–61.CrossRefPubMed
9.
Zurück zum Zitat Ofuchi T, Amemiya A, Takeda A. The efficacy of postmastectomy radiotherapy in patients with breast cancer. Jpn J Breast Cancer. 2006;21:443–9. Ofuchi T, Amemiya A, Takeda A. The efficacy of postmastectomy radiotherapy in patients with breast cancer. Jpn J Breast Cancer. 2006;21:443–9.
10.
Zurück zum Zitat Maaskant AJ, van de Poll-Franse LV, Voogd AC, Coebergh JW, Tutein Nolthenius-Puylaert MC, Nieuwenhuijzen GA. Stage migration due to introduction of the sentinel node procedure: a population-based study. Breast Cancer Res Treat. 2009;113:173–9.CrossRefPubMed Maaskant AJ, van de Poll-Franse LV, Voogd AC, Coebergh JW, Tutein Nolthenius-Puylaert MC, Nieuwenhuijzen GA. Stage migration due to introduction of the sentinel node procedure: a population-based study. Breast Cancer Res Treat. 2009;113:173–9.CrossRefPubMed
11.
Zurück zum Zitat Lingos TI, Recht A, Vicini F, Abner A, Silver B, Harris JR. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1991;21:355–60.CrossRefPubMed Lingos TI, Recht A, Vicini F, Abner A, Silver B, Harris JR. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1991;21:355–60.CrossRefPubMed
12.
Zurück zum Zitat Marchal C, Weber B, de Lafontan B, Resbeut M, Mignotte H, du Chatelard PP, et al. Nine breast angiosarcomas after conservative treatment for breast carcinoma: a survey from French comprehensive Cancer Centers. Int J Radiat Oncol Biol Phys. 1999;44:113–9.CrossRefPubMed Marchal C, Weber B, de Lafontan B, Resbeut M, Mignotte H, du Chatelard PP, et al. Nine breast angiosarcomas after conservative treatment for breast carcinoma: a survey from French comprehensive Cancer Centers. Int J Radiat Oncol Biol Phys. 1999;44:113–9.CrossRefPubMed
13.
Zurück zum Zitat West JG, Qureshi A, West JE, Chacon M, Sutherland ML, Haghighi B, et al. Risk of angiosarcoma following breast conservation: a clinical alert. Breast J. 2005;11:115–23.CrossRefPubMed West JG, Qureshi A, West JE, Chacon M, Sutherland ML, Haghighi B, et al. Risk of angiosarcoma following breast conservation: a clinical alert. Breast J. 2005;11:115–23.CrossRefPubMed
14.
Zurück zum Zitat Taylor CW, Wang Z, Macaulay E, Jagsi R, Duane F, Darby SC. Exposure of the heart in breast cancer radiation therapy: a systematic review of heart doses published during 2003–2013. Int J Radiat Oncol Biol Phys. 2015;93:845–53.CrossRefPubMed Taylor CW, Wang Z, Macaulay E, Jagsi R, Duane F, Darby SC. Exposure of the heart in breast cancer radiation therapy: a systematic review of heart doses published during 2003–2013. Int J Radiat Oncol Biol Phys. 2015;93:845–53.CrossRefPubMed
15.
Zurück zum Zitat Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981–22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014;15:1303–10.CrossRefPubMedPubMedCentral Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981–22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014;15:1303–10.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Coen JJ, Taghian AG, Kachnic LA, Assaad SI, Powell SN. Risk of lymphedema after regional nodal irradiation with breast conservation therapy. Int J Radiat Oncol Biol Phys. 2003;55:1209–15.CrossRefPubMed Coen JJ, Taghian AG, Kachnic LA, Assaad SI, Powell SN. Risk of lymphedema after regional nodal irradiation with breast conservation therapy. Int J Radiat Oncol Biol Phys. 2003;55:1209–15.CrossRefPubMed
17.
Zurück zum Zitat Torres Lacomba M, Yuste Sanchez MJ, Zapico Goni A, Prieto Merino D, Mayoral del Moral O, Cerezo Tellez E, et al. Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial. BMJ. 2010;340:b5396.CrossRefPubMedPubMedCentral Torres Lacomba M, Yuste Sanchez MJ, Zapico Goni A, Prieto Merino D, Mayoral del Moral O, Cerezo Tellez E, et al. Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial. BMJ. 2010;340:b5396.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Tada K. Recommendation for post-mastectomy radiation therapy for breast cancer patients with one to three positive lymph nodes; a) Approval for this idea. Rinsyo Zasshi Geka. 2017;79:402–4. Tada K. Recommendation for post-mastectomy radiation therapy for breast cancer patients with one to three positive lymph nodes; a) Approval for this idea. Rinsyo Zasshi Geka. 2017;79:402–4.
Metadaten
Titel
Post-mastectomy radiation therapy in breast cancer with 1–3 involved lymph nodes: the Pros
verfasst von
Keiichiro Tada
Kotoe Nishioka
Yasuko Kikuchi
Takayoshi Niwa
Yasuyuki Seto
Publikationsdatum
05.06.2017
Verlag
Springer Japan
Erschienen in
Breast Cancer / Ausgabe 4/2017
Print ISSN: 1340-6868
Elektronische ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-017-0787-7

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