nach oben

Erschienen in:

23.03.2018 | REVIEW

Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis

verfasst von: Akiyoshi Kasuga, Yasuo Hamamoto, Ayano Takeuchi, Naohiro Okano, Kazuhiro Togasaki, Yu Aoki, Takeshi Suzuki, Kenta Kawasaki, Kenro Hirata, Yasutaka Sukawa, Takanori Kanai, Hiromasa Takaishi

Erschienen in: Investigational New Drugs | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Summary

Background Post-progression survival (PPS) could be a confounding element in interpreting data from clinical trials of second-line chemotherapy in patients with advanced pancreatic cancer (PC) previously treated with gemcitabine (GEM) because a recent meta-analysis of oxaliplatin combination therapy showed statistical heterogeneity for overall survival (OS) but not for progression-free survival (PFS). This study aimed to improve the understanding of the impact of PPS on OS in this setting. Methods Databases were searched to identify randomized controlled trials (RCTs) in the salvage setting. We evaluated relationships between OS and PFS, PPS, and other variables. Results Totally, 17 RCTs with 3253 patients were identified. Median OS was strongly and moderately associated with median PPS and PFS, respectively (r = 0.913; p < 0.001 and 0.780; p < 0.001, respectively). The proportion of patients with good performance status was significantly associated with both PPS and PFS (r = 0.574, p < 0.001 and 0.492, p < 0.001, respectively). The induction rate of subsequent chemotherapy was related to the duration of PPS and OS (r = 0.640, p < 0.001 and 0.647, p < 0.001, respectively). Median PPS and OS were significantly longer in recent trials than those in older trials (3.55 versus 2.78 months, p < 0.001 and 6.29 versus 5.02 months, p < 0.001). Conclusions Median PPS was strongly correlated with median OS. Given the recently increased opportunity for subsequent chemotherapy and supportive care, PPS may serve as an important element to clarify problems in this setting.

Malvezzi M, Carioli G, Bertuccio P, Boffetta P, Levi F, La Vecchia C, Negri E (2017) European cancer mortality predictions for the year 2017, with focus on lung cancer. Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO 28(5):1117–1123. https://doi.org/10.1093/annonc/mdx033 CrossRef

Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66(1):7–30. https://doi.org/10.3322/caac.21332 CrossRefPubMed

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69–90. https://doi.org/10.3322/caac.20107 CrossRefPubMed

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J, Renschler MF (2013) Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369(18):1691–1703. https://doi.org/10.1056/NEJMoa1304369 CrossRef

Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardiere C, Bennouna J, Bachet JB, Khemissa-Akouz F, Pere-Verge D, Delbaldo C, Assenat E, Chauffert B, Michel P, Montoto-Grillot C, Ducreux M (2011) FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364 (19):1817–1825. doi:https://doi.org/10.1056/NEJMoa1011923

Kasuga A, Hamamoto Y, Takeuchi A, Kawasaki K, Suzuki T, Hirata K, Sukawa Y, Takaishi H, Kanai T (2017) Positive relationship between subsequent chemotherapy and overall survival in pancreatic cancer: meta-analysis of postprogression survival for first-line chemotherapy. Cancer Chemother Pharmacol 79(3):595–602. https://doi.org/10.1007/s00280-017-3263-3 CrossRefPubMed

Kawakami H, Okamoto I, Hayashi H, Taguri M, Morita S, Nakagawa K (2013) Postprogression survival for first-line chemotherapy in patients with advanced gastric cancer. Eur J Cancer (Oxford, England : 1990) 49(14):3003–3009. https://doi.org/10.1016/j.ejca.2013.05.022 CrossRef

Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S (2016) Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib. Hepatology Research : the Official Journal of the Japan Society of Hepatology 46(7):650–656. https://doi.org/10.1111/hepr.12601 CrossRef

Petrelli F, Barni S (2013) Correlation of progression-free and post-progression survival with overall survival in advanced colorectal cancer. Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO 24(1):186–192. https://doi.org/10.1093/annonc/mds289 CrossRef

10.

Pelzer U, Schwaner I, Stieler J, Adler M, Seraphin J, Dorken B, Riess H, Oettle H (2011) Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: a phase III-study from the German CONKO-study group. Eur J Cancer (Oxford, England : 1990) 47(11):1676–1681. https://doi.org/10.1016/j.ejca.2011.04.011 CrossRef

11.

Wang-Gillam A, Li C-P, Bodoky G, Dean A, Shan Y-S, Jameson G, Macarulla T, Lee K-H, Cunningham D, Blanc JF, Hubner RA, Chiu C-F, Schwartsmann G, Siveke JT, Braiteh F, Moyo V, Belanger B, Dhindsa N, Bayever E, Von Hoff DD, Chen L-T (2016) Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet 387(10018):545–557. https://doi.org/10.1016/s0140-6736(15)00986-1 CrossRefPubMed

12.

Oettle H, Riess H, Stieler JM, Heil G, Schwaner I, Seraphin J, Gorner M, Molle M, Greten TF, Lakner V, Bischoff S, Sinn M, Dorken B, Pelzer U (2014) Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial. J Clin Oncol Off J Am Soc Clin Oncol 32(23):2423–2429. https://doi.org/10.1200/jco.2013.53.6995 CrossRef

13.

Gill S, Ko YJ, Cripps C, Beaudoin A, Dhesy-Thind S, Zulfiqar M, Zalewski P, Do T, Cano P, Lam WY, Dowden S, Grassin H, Stewart J, Moore M (2016) PANCREOX: a randomized phase III study of 5-fluorouracil/Leucovorin with or without Oxaliplatin for second-line advanced pancreatic Cancer in patients who have received gemcitabine-based chemotherapy. J Clin Oncol Off J Am Soc Clin Oncol 34:3914–3920. https://doi.org/10.1200/JCO.2016.68.5776 CrossRef

14.

Ohkawa S, Okusaka T, Isayama H, Fukutomi A, Yamaguchi K, Ikeda M, Funakoshi A, Nagase M, Hamamoto Y, Nakamori S, Tsuchiya Y, Baba H, Ishii H, Omuro Y, Sho M, Matsumoto S, Yamada N, Yanagimoto H, Unno M, Ichikawa Y, Takahashi S, Watanabe G, Wakabayashi G, Egawa N, Tsuda M, Hosotani R, Hamada C, Hyodo I (2015) Randomised phase II trial of S-1 plus oxaliplatin vs S-1 in patients with gemcitabine-refractory pancreatic cancer. Br J Cancer 112(9):1428–1434. https://doi.org/10.1038/bjc.2015.103 CrossRefPubMedPubMedCentral

15.

Sonbol MB, Firwana B, Wang Z, Almader-Douglas D, Borad MJ, Makhoul I, Ramanathan RK, Ahn DH, Bekaii-Saab T (2017) Second-line treatment in patients with pancreatic ductal adenocarcinoma: a meta-analysis. Cancer 123:4680–4686. https://doi.org/10.1002/cncr.30927 CrossRefPubMed

16.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ (Clinical research ed) 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557 CrossRef

17.

Saad ED, Katz A, Buyse M (2010) Overall survival and post-progression survival in advanced breast cancer: a review of recent randomized clinical trials. J Clin Oncol Off J Am Soc Clin Oncol 28(11):1958–1962. https://doi.org/10.1200/jco.2009.25.5414 CrossRef

18.

Hayashi H, Okamoto I, Morita S, Taguri M, Nakagawa K (2012) Postprogression survival for first-line chemotherapy of patients with advanced non-small-cell lung cancer. Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO 23(6):1537–1541. https://doi.org/10.1093/annonc/mdr487 CrossRef

19.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed

20.

Ulrich-Pur H, Raderer M, Verena Kornek G, Schull B, Schmid K, Haider K, Kwasny W, Depisch D, Schneeweiss B, Lang F, Scheithauer W (2003) Irinotecan plus raltitrexed vs raltitrexed alone in patients with gemcitabine-pretreated advanced pancreatic adenocarcinoma. Br J Cancer 88(8):1180–1184. https://doi.org/10.1038/sj.bjc.6600883 CrossRefPubMedPubMedCentral

21.

Jacobs AD, Burris HA, Rivkin S, Ritch PS, Eisenberg PD, Mettinger KL (2004) A randomized phase III study of rubitecan (ORA) vs. best choice (BC) in 409 patients with refractory pancreatic cancer report from a north-American multi-center study. J Clin Oncol 22(14_suppl):4013–4013. https://doi.org/10.1200/jco.2004.22.14_suppl.4013 CrossRef

22.

Yoo C, Hwang JY, Kim JE, Kim TW, Lee JS, Park DH, Lee SS, Seo DW, Lee SK, Kim MH, Han DJ, Kim SC, Lee JL (2009) A randomised phase II study of modified FOLFIRI.3 vs modified FOLFOX as second-line therapy in patients with gemcitabine-refractory advanced pancreatic cancer. Br J Cancer 101(10):1658–1663. https://doi.org/10.1038/sj.bjc.6605374 CrossRefPubMedPubMedCentral

23.

Ioka T, Katayama K, Ishida N, Takada R, Yamai T, Fukutake N, Ashida R, Uehara H, Ohigashi H, Takahashi H, Ishikawa O (2013) Randomized phase II study of best available fluoropyrimidine compared with continuation of gemcitabine (gem) monotherapy in patients with gem-refractory pancreatic cancer. J Clin Oncol 31(4_suppl):287–287. https://doi.org/10.1200/jco.2013.31.4_suppl.287 CrossRef

24.

oral presentations (2010). Annals of Oncology 21(suppl_6):vi11–vi19. https://doi.org/10.1093/annonc/mdq268

25.

Ioka T, Komatsu Y, Mizuno N, Tsuji A, Ohkawa S, Tanaka M, Iguchi H, Ishiguro A, Kitano M, Satoh T, Yamaguchi T, Takeda K, Kida M, Eguchi K, Ito T, Munakata M, Itoi T, Furuse J, Hamada C, Sakata Y (2017) Randomised phase II trial of irinotecan plus S-1 in patients with gemcitabine-refractory pancreatic cancer. Br J Cancer 116(4):464–471. https://doi.org/10.1038/bjc.2016.436 CrossRefPubMedPubMedCentral

26.

Wang M, Shi SB, Qi JL, Tang XY, Tian J (2013) S-1 plus CIK as second-line treatment for advanced pancreatic cancer. Med Oncol 30(4):747. https://doi.org/10.1007/s12032-013-0747-9 CrossRefPubMed

27.

Ueno M, Okusaka T, Omuro Y, Isayama H, Fukutomi A, Ikeda M, Mizuno N, Fukuzawa K, Furukawa M, Iguchi H, Sugimori K, Furuse J, Shimada K, Ioka T, Nakamori S, Baba H, Komatsu Y, Takeuchi M, Hyodo I, Boku N (2016) A randomized phase II study of S-1 plus oral leucovorin versus S-1 monotherapy in patients with gemcitabine-refractory advanced pancreatic cancer. Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO 27(3):502–508. https://doi.org/10.1093/annonc/mdv603 CrossRef

28.

Ge F, Xu N, Bai Y, Ba Y, Zhang Y, Li F, Xu H, Jia R, Wang Y, Lin L, Xu J (2014) S-1 as monotherapy or in combination with leucovorin as second-line treatment in gemcitabine-refractory advanced pancreatic cancer: a randomized, open-label, multicenter, phase II study. Oncologist 19(11):1133–1134. https://doi.org/10.1634/theoncologist.2014-0223 CrossRefPubMedPubMedCentral

29.

Hurwitz HI, Uppal N, Wagner SA, Bendell JC, Beck JT, Wade SM 3rd, Nemunaitis JJ, Stella PJ, Pipas JM, Wainberg ZA, Manges R, Garrett WM, Hunter DS, Clark J, Leopold L, Sandor V, Levy RS (2015) Randomized, double-blind, phase II study of Ruxolitinib or placebo in combination with Capecitabine in patients with metastatic pancreatic Cancer for whom therapy with gemcitabine has failed. J Clin Oncol Off J Am Soc Clin Oncol 33(34):4039–4047. https://doi.org/10.1200/JCO.2015.61.4578 CrossRef

30.

Chung V, McDonough S, Philip PA, Cardin D, Wang-Gillam A, Hui L, Tejani MA, Seery TE, Dy IA, Al Baghdadi T, Hendifar AE, Doyle LA, Lowy AM, Guthrie KA, Blanke CD, Hochster HS (2017) Effect of Selumetinib and MK-2206 vs Oxaliplatin and fluorouracil in patients with metastatic pancreatic Cancer after prior therapy: SWOG S1115 study randomized clinical trial. JAMA Oncology 3(4):516–522. https://doi.org/10.1001/jamaoncol.2016.5383 CrossRefPubMedPubMedCentral

31.

Ueno M, Ohkawa S, Kobayashi N, Sugimori K, Kawaguchi Y, Kobayashi S, Taguri M, Yamanaka T, Mine T (2017) Randomized phase II study of S-1 monotherapy versus gemcitabine plus S-1 in gemcitabine-refractory advanced pancreatic cancer. J Clin Oncol 35(4_suppl):429–429. https://doi.org/10.1200/JCO.2017.35.4_suppl.429 CrossRef

32.

Ueno M, Ioka T, Ueno H, Park JO, Chang H-M, Sasahira N, Kanai M, Chung I-J, Ikeda M, Nakamori S, Mizuno N, Omuro Y, Yamaguchi T, Hara H, Sugimori K, Furuse J, Takeuchi M, Okusaka T, Boku N, Hyodo I (2017) TAS-118 (S-1 plus leucovorin) versus S-1 in gemcitabine-refractory advanced pancreatic cancer: A randomized, open-label, phase III trial (GRAPE trial). J Clin Oncol 35(15_suppl):4099–4099. https://doi.org/10.1200/JCO.2017.35.15_suppl.4099 CrossRef

33.

Hurwitz H, Van Cutsem E, Bendell J, Hidalgo M, Li CP, Salvo MG, Macarulla T, Sahai V, Sama A, Greeno E, Yu KH, Verslype C, Dawkins F, Walker C, Clark J, O'Reilly EM (2018) Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies. Investig New Drugs. https://doi.org/10.1007/s10637-018-0580-2

34.

Kasuga A, Okano N, Naruge D, Kitamura H, Takasu A, Nagashima F, Furuse J (2015) Retrospective analysis of fixed dose rate infusion of gemcitabine and S-1 combination therapy (FGS) as salvage chemotherapy in patients with gemcitabine-refractory advanced pancreatic cancer: inflammation-based prognostic score predicts survival. Cancer Chemother Pharmacol 75(3):457–464. https://doi.org/10.1007/s00280-014-2665-8 CrossRefPubMed

35.

Sinn M, Dalken L, Striefler JK, Bischoff S, Schweitzer N, Pelzer U, Dorken B, Riess H, Stieler JM (2016) Second-line treatment in pancreatic Cancer patients: who profits?--results from the CONKO study group. Pancreas 45(4):601–605. https://doi.org/10.1097/mpa.0000000000000533 CrossRefPubMed

36.

Vienot A, Beinse G, Louvet C, de Mestier L, Meurisse A, Fein F, Heyd B, Cleau D, d'Engremont C, Dupont-Gossart AC, Lakkis Z, Tournigand C, Bouche O, Rousseau B, Neuzillet C, Bonnetain F, Borg C, Vernerey D (2017) Overall survival prediction and usefulness of second-line chemotherapy in advanced pancreatic adenocarcinoma. J Natl Cancer Inst 109(10). https://doi.org/10.1093/jnci/djx037

37.

Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12(5):489–495. https://doi.org/10.1016/s1470-2045(10)70218-7 CrossRefPubMed

38.

Ouyang H, Ma W, Liu F, Yue Z, Fang M, Quan M, Pan Z (2017) Factors influencing survival of patients with pancreatic adenocarcinoma and synchronous liver metastases receiving palliative care. Pancreatology : Official Journal of the International Association of Pancreatology 17(5):773–781. https://doi.org/10.1016/j.pan.2017.07.002 CrossRef

39.

Iino C, Shimoyama T, Igarashi T, Aihara T, Ishii K, Sakamoto J, Tono H, Fukuda S (2017) Biliary drainage improves the predictive value of modified Glasgow prognostic scores in inoperable pancreatic cancer. PLoS One 12(6):e0178777. https://doi.org/10.1371/journal.pone.0178777 CrossRefPubMedPubMedCentral

40.

Hayashi H, Okamoto I, Taguri M, Morita S, Nakagawa K (2013) Postprogression survival in patients with advanced non-small-cell lung cancer who receive second-line or third-line chemotherapy. Clin Lung Cancer 14(3):261–266. https://doi.org/10.1016/j.cllc.2012.09.006 CrossRefPubMed

Titel: Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis
verfasst von: Akiyoshi Kasuga
Yasuo Hamamoto
Ayano Takeuchi
Naohiro Okano
Kazuhiro Togasaki
Yu Aoki
Takeshi Suzuki
Kenta Kawasaki
Kenro Hirata
Yasutaka Sukawa
Takanori Kanai
Hiromasa Takaishi
Publikationsdatum: 23.03.2018
Verlag: Springer US
Erschienen in: Investigational New Drugs / Ausgabe 5/2018
Print ISSN: 0167-6997
Elektronische ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-018-0589-6

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis

Summary

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2018

Survival and tolerance to sorafenib in Child-Pugh B patients with hepatocellular carcinoma: a prospective study

Pre-clinical effects of metformin and aspirin on the cell lines of different breast cancer subtypes

Phase I study of CKD-581, a pan-histone deacetylase inhibitor, in patients with lymphoma or multiple myeloma refractory to standard therapy

The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line

A phase 1 study of PARP-inhibitor ABT-767 in advanced solid tumors with BRCA1/2 mutations and high-grade serous ovarian, fallopian tube, or primary peritoneal cancer

A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie