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Erschienen in: Journal of Neural Transmission 5/2017

08.03.2017 | Psychiatry and Preclinical Psychiatric Studies - Short communication

Post-reexposure administration of d-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats

verfasst von: Akiyoshi Saitoh, Kie Akagi, Jun-Ichiro Oka, Mitsuhiko Yamada

Erschienen in: Journal of Neural Transmission | Ausgabe 5/2017

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Abstract

The effect of d-cycloserine, a N-methyl-d-aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of d-cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a mild fear-conditioning procedure and with post-reexposure administration of the drug. The d-cycloserine (15 mg/kg subcutaneously)-treated rats showed a persistent and greater fear response during the test session compared with the control group. In conclusion, we have confirmed that post-reexposure administration of d-cycloserine facilitates the reconsolidation of fear memory in rats.
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Metadaten
Titel
Post-reexposure administration of d-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats
verfasst von
Akiyoshi Saitoh
Kie Akagi
Jun-Ichiro Oka
Mitsuhiko Yamada
Publikationsdatum
08.03.2017
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 5/2017
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-017-1704-0

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