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Erschienen in: Inflammation 4/2012

01.08.2012

Postconditioning with α7nAChR Agonist Attenuates Systemic Inflammatory Response to Myocardial Ischemia–Reperfusion Injury in Rats

verfasst von: Jun Xiong, Yu-Jing Yuan, Fu-Shan Xue, Qiang Wang, Yi Cheng, Rui-Ping Li, Xu Liao, Jian-Hua Liu

Erschienen in: Inflammation | Ausgabe 4/2012

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Abstract

The inflammatory response plays a major role in ischemia–reperfusion injury (IRI). Considering that cholinergic stimulation can inhibit inflammatory response through the cholinergic anti-inflammatory pathway (CAP) and the α subunit-containing nicotinic acetylcholine receptor(α7nAChR) expressed by immune cells is an important component of CAP, we assessed the effect of postconditioning with α7nAChR agonist on systemic inflammatory response during the myocardial ischemia–reperfusion process in an in vivo rat model. Thirty Sprague Dawley rats were randomly divided into three groups: sham group, control group, and postconditioning with α7nAChR agonist group (PP group). In the groups other than the sham group, the left anterior descending coronary artery was ligated for 30 min followed by a 180-min reperfusion. At the end of the experiment, the serum levels of troponin I, tumor necrosis factor α, interleukin-6, and high-mobility group box 1 were assayed, and the infarct size was assessed. The results showed that postconditioning with α7nAChR agonist significantly attenuated the systemic inflammatory response to myocardial IRI, as evidenced by decreased serum levels of tumor necrosis factor α and high-mobility group box 1. Also, this treatment protected against myocardial IRI, as shown by reduced infarct size and serum troponin I level.
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Metadaten
Titel
Postconditioning with α7nAChR Agonist Attenuates Systemic Inflammatory Response to Myocardial Ischemia–Reperfusion Injury in Rats
verfasst von
Jun Xiong
Yu-Jing Yuan
Fu-Shan Xue
Qiang Wang
Yi Cheng
Rui-Ping Li
Xu Liao
Jian-Hua Liu
Publikationsdatum
01.08.2012
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 4/2012
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-012-9449-2

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