Background
Methods
Study sample
Physical activity assessment
Clinical and socio-demographic characteristics
Vital status ascertainment
Statistical analyses
Results
Participant characteristics
Quartiles of total physical activity | ||||||
---|---|---|---|---|---|---|
Participant characteristics | Overall sample | Q1 (0–64.5) | Q2 (>64.5–99.7) | Q3 (>99.7–144.9) | Q4 (>144.9) |
p
a
|
Total no. of individuals, n | 1376 | 344 | 344 | 344 | 344 | |
No. of deaths, n (%) | 200 (15) | 85 (25) | 47 (14) | 33 (10) | 35 (10) | <0.0001 |
Sex, n (%) | ||||||
Men | 770 (56) | 224 (65) | 200 (58) | 176 (51) | 170 (49) | |
Women | 606 (44) | 120 (35) | 144 (42) | 168 (49) | 174 (51) | <0.0001 |
Age at diagnosis, y | 62 (57–66) | 63 (57–70) | 62 (56–66) | 62 (57–66) | 61 (56–65) | 0.0002 |
Age at physical activity assessment, y | 69 (64–73) | 70 (65–77) | 69 (64–74) | 69 (65–73) | 68 (63–72) | 0.0006 |
Time between CRC diagnosis and physical activity assessment, y | 6 (5–8) | 6 (5–8) | 7 (5–8) | 7 (5–8) | 6 (5–8) | 0.37 |
BMI, kg/m2
| 26.2 (23.8–29.3) | 26.6 (24.0–29.4) | 26.0 (23.7–29.3) | 26.1 (23.8–29.1) | 26.0 (23.7–29.2) | 0.63 |
Smoking status, n (%) | ||||||
Never | 556 (40) | 123 (36) | 140 (41) | 143 (42) | 150 (44) | |
Former | 678 (49) | 177 (51) | 171 (50) | 170 (49) | 160 (47) | |
Current | 121 (9) | 37 (11) | 30 (9) | 26 (8) | 28 (8) | |
Unknown | 21 (2) | 7 (2) | 3 (1) | 5 (1) | 6 (2) | 0.57 |
Alcohol intake, g/day | 7 (2–20) | 5 (1–20) | 8 (2–23) | 7 (3–18) | 7 (2–18) | 0.01 |
Tumor location, n (%) | ||||||
Colon | 657 (48) | 166 (48) | 168 (49) | 170 (49) | 148 (43) | |
Rectum | 576 (42) | 147 (43) | 144 (42) | 137 (40) | 153 (44) | |
Both | 62 (5) | 13 (4) | 13 (4) | 21 (6) | 15 (4) | |
Unknown | 81 (6) | 18 (5) | 19 (5) | 16 (5) | 28 (8) | 0.48 |
Metastases, n (%) | ||||||
Yes | 234 (17) | 70 (20) | 48 (14) | 54 (16) | 56 (16) | |
No | 908 (66) | 207 (60) | 248 (72) | 227 (66) | 226 (66) | |
Unknown | 234 (17) | 67 (19) | 48 (14) | 63 (18) | 62 (18) | 0.06 |
Other Cancer, n (%) | ||||||
Yes | 292 (21) | 73 (21) | 79 (23) | 68 (20) | 72 (21) | |
No | 1054 (77) | 261 (76) | 260 (76) | 268 (78) | 265 (77) | |
Unknown | 30 (2) | 10 (3) | 5 (1) | 8 (2) | 7 (2) | 0.84 |
Therapy, n (%) | ||||||
None | 721 (52) | 182 (53) | 191 (56) | 168 (49) | 180 (52) | |
Chemotherapy | 305 (22) | 85 (25) | 68 (20) | 80 (23) | 72 (21) | |
Radiation | 45 (3) | 6 (2) | 18 (5) | 11 (3) | 10 (3) | |
Chemotherapy and radiation | 282 (20) | 65 (19) | 59 (17) | 80 (23) | 78 (23) | |
Unknown | 23 (2) | 6 (2) | 8 (2) | 5 (1) | 4 (1) | 0.18 |
Postdiagnostic physical activity, sleep duration, and TV watching and all-cause mortality
Total no. of individuals | No. of deaths | Age- & sex-adjusted HR (95% CI) | Multivariable-adjustedb HR (95% CI) | |
---|---|---|---|---|
MET-hours/week of total physical activity
| ||||
Quartile 1 (0–64.5) | 344 | 85 | 1.00 (Ref.) | 1.00 (Ref.) |
Quartile 2 (>64.5–99.7) | 344 | 47 | 0.61 (0.42–0.87) | 0.65 (0.45–0.94) |
Quartile 3 (>99.7–144.9) | 344 | 33 | 0.45 (0.30–0.68) | 0.52 (0.34–0.79) |
Quartile 4 (>144.9) | 344 | 35 | 0.51 (0.34–0.77) | 0.53 (0.36–0.80) |
ptrend
c
| 0.0004 | 0.0006 | ||
MET-hours/week of sports activities
d
| ||||
0 | 708 | 150 | 1.00 (Ref.) | 1.00 (Ref.) |
> 0–10 | 146 | 10 | 0.42 (0.22–0.81) | 0.41 (0.22–0.80) |
> 10–20 | 261 | 25 | 0.56 (0.37–0.86) | 0.58 (0.37–0.89) |
> 20 | 261 | 15 | 0.33 (0.19–0.56) | 0.34 (0.20–0.59) |
ptrend
c
| <0.0001 | <0.0001 | ||
MET-hours/week of cycling activities
d
| ||||
0 | 503 | 102 | 1.00 (Ref.) | 1.00 (Ref.) |
> 0–10 | 236 | 31 | 0.75 (0.50–1.14) | 0.80 (0.52–1.22) |
> 10–20 | 241 | 27 | 0.71 (0.45–1.10) | 0.90 (0.57–1.41) |
> 20 | 396 | 40 | 0.61 (0.42–0.90) | 0.85 (0.57–1.27) |
ptrend
c
| 0.02 | 0.52 | ||
MET-hours/week of walking activities
d
| ||||
0–10 | 409 | 75 | 1.00 (Ref.) | 1.00 (Ref.) |
> 10–20 | 386 | 56 | 0.82 (0.58–1.16) | 0.83 (0.58–1.19) |
> 20–30 | 297 | 37 | 0.65 (0.44–0.96) | 0.67 (0.45–1.00) |
> 30 | 284 | 32 | 0.62 (0.41–0.94) | 0.65 (0.43–1.00) |
ptrend
c
| 0.01 | 0.03 | ||
MET-hours/week of gardening activities
d
| ||||
0 | 297 | 69 | 1.00 (Ref.) | 1.00 (Ref.) |
> 0–10 | 358 | 48 | 0.72 (0.49–1.06) | 0.81 (0.55–1.20) |
> 10–20 | 264 | 23 | 0.38 (0.23–0.61) | 0.41 (0.25–0.68) |
> 20 | 457 | 60 | 0.55 (0.38–0.79) | 0.62 (0.42–0.91) |
ptrend
c
| 0.003 | 0.01 | ||
MET-hours/week of housework, home repair, and stair climbing activities
d
| ||||
0–10 | 177 | 45 | 1.00 (Ref.) | 1.00 (Ref.) |
> 10–20 | 221 | 29 | 0.60 (0.37–0.95) | 0.65 (0.40–1.05) |
> 20–30 | 194 | 29 | 0.69 (0.43–1.10) | 0.72 (0.45–1.17) |
> 30 | 784 | 97 | 0.70 (0.48–1.01) | 0.83 (0.55–1.23) |
ptrend
c
| 0.35 | 0.99 | ||
Hours of sleeping at night
e
| ||||
≤ 6 | 294 | 42 | 1.03 (0.72–1.45) | 0.97 (0.68–1.38) |
7–8 | 933 | 132 | 1.00 (Ref.) | 1.00 (Ref.) |
≥ 9 | 149 | 26 | 1.08 (0.71–1.65) | 0.99 (0.65–1.53) |
ptrend
c
| 0.95 | 0.87 | ||
Hours of sleeping at day
e
| ||||
0 | 607 | 57 | 1.00 (Ref.) | 1.00 (Ref.) |
> 0 – <1 | 98 | 7 | 0.58 (0.26–1.27) | 0.53 (0.24–1.17) |
1 – <2 | 558 | 94 | 1.19 (0.85–1.68) | 1.17 (0.82–1.65) |
≥ 2 | 113 | 42 | 2.63 (1.72–4.02) | 2.22 (1.43–3.44) |
ptrend
c
| <0.0001 | 0.0004 | ||
Hours/day of watching TV
f
| ||||
≤ 2 | 480 | 55 | 1.00 (Ref.) | 1.00 (Ref.) |
> 2 – <4 | 414 | 59 | 1.16 (0.80–1.68) | 1.23 (0.85–1.79) |
≥ 4 | 482 | 86 | 1.28 (0.91–1.80) | 1.45 (1.02–2.06) |
ptrend
c
| 0.16 | 0.04 |