The choice of surgical methods for lumbosacral tuberculosis is controversial due to the complex anterior anatomy and peculiar biomechanics of the lumbosacral junction. The objective of this study was to explore the clinical effect of posterior intervertebral space debridement with annular bone graft fusion and fixation for the treatment of lumbosacral tuberculosis.
Methods
We retrospectively analysed data from 23 patients with lumbosacral tuberculosis who had undergone posterior intervertebral space debridement with annular bone fusion and fixation between January 2008 and September 2014. The mean age of the patients was 49.0 years (range, 27–71), and the mean duration of disease until treatment was 10.2 months (range, 6–20). The lumbosacral angle, visual analogue scale (VAS) score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, American Spinal Injury Association (ASIA) grade and Social Functioning-36 (SF-36) score were determined to ascertain the clinical effects of the treatment.
Results
All patients underwent follow-up observation. The mean follow-up time was 34.2 months (range, 18–45), the mean operation time was 167.0 min (range, 130–210) and the mean blood loss was 767.4 ml (range, 500–1150). The lumbosacral angle was 21.0° ± 2.1° before operation, rising to 28.8° ± 1.7° after operation (p < 0.05) and being maintained thereafter. The mean VAS score before operation was 8.1 ± 0.6, decreasing to 1.2 ± 0.5 (p < 0.05) at the final follow-up. The mean ESR and CRP values were 49.1 ± 5.6 mm and 64.9 ± 11.9 mg/L, respectively, before operation, decreasing to normal at the final follow-up. The preoperative ASIA grade was C in 6 patients, D in 12 and E in 5. At the final follow-up, all patients had an ASIA grade of E except for one patient with a grade of D. For all patients, the SF-36 score at the final follow-up was higher than the preoperative and postoperative scores.
Conclusions
Posterior intervertebral space debridement with annular bone graft fusion and fixation is an effective treatment for lumbosacral spine tuberculosis.
Abkürzungen
ASIA
American Spinal Injury Association
CRP
C-reactive protein
CT
Computed tomography
ESR
Erythrocyte sedimentation rate
Final
Final follow up
MRI
Magnetic resonance imaging
SF-36
Social Functioning-36
VAS
Visual analog scale
Background
The lumbosacral region includes the distal lumbar vertebrae and all sacral vertebrae and mainly refers to L3 and lower levels [1, 2]. Tuberculosis of the lumbosacral region is rare, accounting for about 2%–3% of all cases of spinal tuberculosis [1, 3]. Although most cases of lumbosacral tuberculosis can be cured with conservative therapy, in some cases chronic low back pain and bad alignment of lumbar lordosis persist even with treatment. Surgical treatment is advocated for cases complicated by local instability or destructive vertebral body lesions.
Anterior debridement and bone grafting combined with posterior instrumentation is the leading surgical treatment for lumbosacral junction tuberculosis because it has the advantages of complete debridement under direct vision, excellent anterior column reconstruction and solid posterior fixation [3‐5]. However, due to the complicated anatomic structure and unclear view of prevertebral inflammatory organisation, the risk of vascular, nerve and visceral injury is relatively high [6]. Moreover, accidental injury of the hypogastric nerve by this approach can bring about the severe complication of retrograde ejaculation in male patients [7, 8]. In consideration of these disadvantages, we tried the procedure of posterior intervertebral space debridement with annular bone graft fusion and fixation for the treatment of lumbosacral tuberculosis to ascertain the feasibility and effects of the procedure.
Anzeige
Methods
Patient population
This retrospective study enrolled 23 patients (12 men and 11 women) with lumbosacral tuberculosis who had undergone posterior transintervertebral space debridement with annular bone graft fusion and fixation between January 2008 and September 2014. The mean age of the patients was 49.0 years (range, 27–71), and the mean duration of disease until treatment was 10.2 months (range, 6–20). There were 3 patients with L3–4 lesions, 11 with L4–5 lesions and 9 with L5–S1 lesions. All patients were examined with anteroposterior and lateral X-rays. Computed tomography (CT) and magnetic resonance imaging (MRI) were performed to determine local pathological changes and eliminate other diseases of the lumbosacral region. All patients had lumbosacral pain; 14 patients had low fever, sweating, emaciation and other symptoms of tubercular toxicity; 17 patients had complications of radiating pain and numbness in the lower extremity; 18 patients experienced weakness in walking and 1 patient presented with cauda equina syndrome. On clinical examination, most patients presented only with lumbosacral pain, eight patients had limited lumbar flexion and six patients had significant weakness of the lower extremity. All preoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values were above normal limits. Except for seven patients who only presented with intervertebral space narrowing, all patients were found to have various degrees of bone destruction on X-ray examination. All patients were found to have obvious bone destruction and paravertebral abscesses on CT and MRI examination.
The study protocol was approved by the ethics review committee of the Shaanxi Provincial People’s Hospital (No. K20070313–021).
Preoperative preparation
The T-SPOT.TB test was used to confirm the presence of tuberculosis. All patients with suspected tuberculosis received 2–4 weeks of standard HREZ chemotherapy (300 mg/day isoniazid, 450 mg/day rifampicin, 750 mg/day ethambutol and 750 mg/day pyrazinamide) before surgery. Anaemia and hypoproteinaemia were corrected preoperatively. If there was no significant decrease in the ESR, levofloxacin injection (i.v.gtt, 400 mg/d) was added to enhance the effect of the antituberculosis therapy.
Operative technique
With the patient in the prone position, a posterior midline skin incision was made after induction of general anaesthesia by tracheal intubation, and subperiosteal dissection was performed up to the lateral part of the superior zygopophysis. Pedicle screws were used in the adjacent normal vertebrae (Fig. 1). If the destruction of the pathological lumbar vertebrae was slight, pedicle screws were used. If the destruction of the S1 vertebra was severe, iliac screws were used for lumbopelvic fixation (Fig. 2). A short rod was temporarily installed to stabilise the operative segment during decompression and focal debridement. Total laminectomy under protection of the facet joints was performed, and cotton pieces were used to protect the dura. Under protection of the dura and nerve roots, curettes of various sizes and angles and high-speed burrs were used to remove abnormal bone (especially sclerous bone) down to healthy haemorrhagic bone. A 90° curette was used cautiously to push and scrape paravertebral pathological tissue, and a positive pressure catheter was inserted into the intervertebral space or paravertebral tissue to drain pus and assist in clearing necrotic tissue. We trimmed the bone grafting area and extracted the bone fragment from the iliac (iliac block) and granules, then put the iliac block into the intervertebral space and tamped osseous granules around the iliac block. We cut the lamina into pieces and implanted them around the facets and the transverse processes. The diseased material was sent for microorganism culture and histopathological examination.
Fig. 1
A 46-year-old female patient with lumbosacral tuberculosis with L4–5 lesions who underwent posterior intervertebral space debridement with annuar bone graft fusion and fixation. a-e Preoperative X-ray, computed tomography (CT) and magnetic resonance imaging showed bone destruction and abscess formation. f The intraoperative image showed posterior fixation, decompression and transintervertebral space debridement. g-j Postoperative radiographs. Postoperative CT in the axial and sagittal planes at 14 months showed a good position of internal fixation and excellent intervertebral bone fusion
Fig. 2
A 61-year-old female patient with lumbosacral tuberculosis with L5–S1 intervertebral lesion who also underwent posterior intervertebral space debridement with annular bone graft fusion and fixation. a-f Preoperative images. Preoperative computed tomography (CT) and magnetic resonance imaging showed bone destruction and extensive flow abscess (c–f). g-j Postoperative radiographs. Postoperative CT in the coronal and sagittal planes at 18 months showed a good position of internal fixation and excellent intervertebral bone fusion
×
×
Anzeige
Postoperative care
Breath, pulse, blood pressure and temperature were monitored postoperatively. Mobility and sensation of the lower limbs were closely observed. The drainage tube was extracted when the volume of drainage was <50 ml/d. The patients underwent straight leg raising exercises and ankle pump training during bed rest. We regularly monitored routine blood parameters, ESR, CRP and liver function, performed X-rays of the lumbar spine and, if necessary, performed CT scanning of the surgical segment. Standard HREZ chemotherapy was continued for more than 12 months. Ambulation with a brace was allowed at 6–8 weeks after surgery. The patients performed non–weight-bearing daily activities until radiographic (X-ray or CT) evidence of fusion was observed. The patients then returned to normal weight-bearing activities.
Postoperative evaluation
Preoperatively and at the final follow-up, the American Spinal Injury Association (ASIA) grade was used to evaluate neurological function. At the same time points, the visual analogue scale (VAS) was used to assess low back pain, and tuberculosis activity was monitored by measuring ESR and CRP. The lumbosacral angle and Social Functioning-36 (SF-36) scores were measured at preoperation, postoperation and final follow-up. Bone graft fusion and instrumentation failure were monitored by radiography.
Statistical analysis
The paired t-test was used to evaluate differences in lumbosacral angle, VAS, ESR, CRP and SF-36 among preoperation, postoperation and final follow-up. The Wilcoxon signed rank test was used to evaluate differences in ASIA grade. A p-value <0.05 was considered to indicate a statistically significant difference.
Results
All patients underwent follow-up observation. The mean follow-up time was 34.2 months (range, 18–45), the mean operation time was 167.0 min (range, 130–210) and the mean blood loss was 767.4 ml (range, 500–1150) (Table 1). Except for one relapsed patient who was cured by debridement of a second abscess via a small anterior incision, all patients achieved stage 1 healing. The lumbosacral angle was 21.0° ± 2.1° before operation, rising to 28.8° ± 1.7° after operation (p < 0.05) and being maintained thereafter. The difference between the lumbosacral angle before and after operation was statistically significant (p < 0.05), and there was no significant loss of postoperative lumbosacral angle during follow-up (p > 0.05). Tuberculosis toxic symptoms had vanished in all patients at the final follow-up. The mean VAS score at the final follow-up was 1.2 ± 0.5 (range, 0–3), significantly lower than the mean preoperative score (8.1 ± 0.6) (Table 2).
Table 1
Patient demographics, operative information and disease characteristics
Case no.
Age (years)/sex
Level
Duration of symptoms (months)
Blood loss (ml)
Operation time (min)
Follow-up (months)
1
49/M
L5-S1
13
1150
200
45
2
51/F
L4–5
8
1000
150
38
3
49/M
L5-S1
12
700
150
35
4
48/F
L4–5
9
950
160
30
5
57/M
L5-S1
11
1050
210
38
6
45/F
L5-S1
7
600
140
31
7
45/M
L4–5
14
900
170
28
8
51/M
L3–4
7
850
150
31
9
71/M
L5-S1
6
500
170
38
10
48/F
L5-S1
8
750
210
36
11
63/F
L3–4
9
800
160
45
12
51/M
L5-S1
20
800
200
18
13
37/M
L4–5
9
650
190
36
14
42/M
L4–5
13
800
170
42
15
61/F
L5-S1
8
950
200
28
16
47/F
L4–5
13
500
130
35
17
55/F
L4–5
10
550
140
31
18
35/M
L4–5
9
750
180
42
19
46/F
L4–5
11
600
130
29
20
52/F
L4–5
9
850
170
32
21
55/M
L5-S1
10
500
140
36
22
41/F
L3–4
12
700
150
35
23
27/M
L4–5
6
750
170
28
Mean
49.0 ± 9.5
10.2 ± 3.2
767.4 ± 181.2
167.0 ± 25.1
34.2 ± 6.3
Table 2
Summary of radiological and clinical outcomes
Case no.
Lumbosacral angle (°)
ASIA grade
VAS
ESR (mm/h)
CRP (mg/L)
Pre
Post*
Final
Pre
FinalΔ
Pre
Final*
Pre
Final*
Pre
Final*
1
19
28
27
C
E
8
1
46
15
69
3.0
2
25
31
30
C
E
7
0
42
13
48
1.5
3
25
30
28
D
E
9
1
39
12
45
2.5
4
22
29
27
E
E
9
1
48
13
51
3.5
5
18
27
26
E
E
8
1
52
10
79
2.0
6
21
27
27
E
E
7
1
49
13
71
2.5
7
19
27
25
C
E
9
0
52
11
83
3.5
8
20
26
25
D
E
9
1
65
12
97
3.0
9
26
33
32
E
E
8
2
58
14
85
3.5
10
20
29
29
E
E
8
1
61
13
91
1.0
11
25
32
31
C
D
8
1
37
14
50
4.5
12
18
25
23
C
E
7
2
38
15
48
3.5
13
17
27
26
D
E
8
2
47
12
55
3.5
14
24
30
30
D
E
7
0
45
13
56
3.0
15
19
29
28
D
E
9
2
57
10
69
2.5
16
22
29
27
D
E
9
2
53
14
75
1.5
17
21
28
28
D
E
8
1
50
11
64
2.0
18
19
27
26
D
E
8
3
47
13
63
2.5
19
21
30
29
D
E
7
1
56
13
68
2.5
20
18
27
27
C
E
8
1
39
11
47
2.0
21
23
32
30
D
E
9
1
49
12
52
3.5
22
21
31
28
D
E
8
1
48
14
62
3.5
23
20
29
29
D
E
8
1
51
13
65
3.0
Mean
21.0 ± 2.1
28.8 ± 1.7
27.7 ± 1.7
8.1 ± 0.6
1.2 ± 0.5
49.1 ± 5.6
12.7 ± 1.1
64.9 ± 11.9
2.8 ± 0.7
Pre preoperative, Post postoperative, Final final follow-up, ASIA American Spinal Injury Association, VAS visual analogue scale, ESR erythrocyte sedimentation rate, CRP C-reactive protein
*p < 0.05 compared with preop by paired t-test
Δp < 0.05 compared with preop by Wilcoxon signed rank test
ESR and CRP were recovered to normal levels (12.7 ± 1.1 mm/h and 2.8 ± 0.7 mg/L, respectively) at the final follow-up. At the final follow-up, all patients had an ASIA grade of E except for one patient with a grade of D (Table 2). The postoperative SF-36 scores for Physical Functioning, Role-Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role-Emotional and Mental Health were 80.94 ± 3.30, 29.70 ± 14.24, 69.5 ± 13.06, 70.27 ± 9.92, 78.37 ± 9.86, 73.08 ± 9.88, 63.43 ± 18.70 and 83.78 ± 2.97, respectively. All these values were significantly (p < 0.05) higher than the preoperative scores of 77.43 ± 4.67, 27.0 ± 17.05, 24.59 ± 0.50, 68.2 ± 11.25, 72.43 ± 9.83, 69.00 ± 6.26, 59.8 ± 13.77 and 81.40 ± 3.55. The scores for each part of the SF-36 increased gradually during the follow-up period, and all scores were significantly (p < 0.05) higher than the postoperative scores at the final follow-up (Table 3). All grafted bone achieved solid fusion according to X-ray examination (partial fusion by CT scan); the mean time to bone fusion was 6.5 months (range, 6–10). There was no loose fixation, dislocation or rupture.
Table 3
Preoperative, postoperative and final follow-up SF-36 scores
Characteristic
Preop
Postop
Final follow up
PF
77.43 ± 4.67
80.94 ± 3.30*
87.43 ± 8.38Δ
RP
27.0 ± 17.05
29.70 ± 14.24*
39.8 ± 12.44Δ
BP
24.59 ± 0.50
69.5 ± 13.06*
78.57 ± 3.56Δ
GH
68.2 ± 11.25
70.27 ± 9.92*
77.70 ± 7.87Δ
VT
72.43 ± 9.83
78.37 ± 9.86*
85.90 ± 11.42Δ
SF
69.00 ± 6.26
73.08 ± 9.88*
81.10 ± 13.01Δ
RE
59.8 ± 13.77
63.43 ± 18.70*
72.50 ± 20.52Δ
MH
81.40 ± 3.55
83.78 ± 2.97*
89.08 ± 6.64Δ
SF-36, Social Functioning-36, PF Physical Functioning, RP Role-Physical, BP Bodily Pain, GH General Health, VT Vitality, SF Social Functioning, RE Role-Emotional, MH Mental Health, preop preoperation, postop postoperation
*p < 0.05 compared with preop by paired t-test
Δp < 0.05 compared with postop by paired t-test
Discussion
With the resurgence of tuberculosis, the incidence of spinal tuberculosis has increased in recent years [9, 10]. Lumbosacral junction tuberculosis accounts for only a small proportion of spinal tuberculosis (about 2%–3%) [3, 11], but due to the anatomical and biomechanical particularities of the lumbosacral junction, its treatment is controversial. The clinical manifestation of lumbosacral junction tuberculosis is slightly different from that of typical thoracic and lumbar tuberculosis, usually presenting only as slight low back pain, occasionally accompanied by symptoms of sciatic nerve irritation. There is never severe neurological dysfunction or kyphosis [12].
The blood supply of the lumbosacral junction is poor. Once Mycobacterium tuberculosis has migrated to and caused disease in this site [13]. Moreover, the lumbosacral junction is one of the most significant stress-concentrating segments of the spine (a transitional segment from an active lumbar vertebra to a fixed sacral vertebra) and is hard to immobilise and rest. As a result, the lumbosacral junction is difficult to treat [14].
The application of antituberculosis drugs is the basis of the treatment of spinal tuberculosis [15]. In the early stage of spinal tuberculosis, antituberculosis drugs can effectively reach the lesion area, but with the progress of the disease, the local blood flow of the lesion gradually deteriorates, while the tuberculosis bacilli are wrapped in granulation and necrosis, so that the drugs cannot exert an effective antibiotic action against the tuberculosis bacilli that are residing in the lesion [16]. Appropriate surgical therapy can significantly improve the local blood supply, break the drug barrier, shorten the course of the disease and reduce the occurrence of complications [17].
Anzeige
The aim of surgical treatment of lumbosacral junction tuberculosis is radical debridement to wipe out the factors detrimental to neural recovery and restore normal spine alignment. An anterior approach can directly remove paravertebral abscesses and vertebral sequestrum and perform effective intervertebral grafting, but due to the complex anterior anatomy of the lumbosacral junction, its ambiguous pathological structure, fragile invading blood vessels and thick, sticky adjacent tissue, the risk to the presacral vessels and the ureter is increased [18]. Accidental injury to the hypogastric nerve in male patients may lead to the severe complication of retrograde ejaculation [7, 8]. Moreover, the backward slant of the sacrococcyx makes implantation in the anterior region difficult [19]. Even if fixation in the anterior region is performed during anterior surgery, the instrument is difficult to extract later because of the complicated anterior anatomic structures. Considering these difficulties, some surgeons have adopted combined anterior and posterior surgery to treat patients with lumbosacral junction tuberculosis. The normal sequence of the lumbosacral junction can be established through solid posterior fixation. Moreover, by effective anterior focus clearance and intervertebral bone grafting, the stability of the lumbosacral junction can be maintained in the long run [2, 20]. Furthermore, the lumbosacral junction needs no extensive anterior exposure. However, the surgical trauma is great, and the operative position needs to be changed [21].
Pang et al. [22] and Zhang et al. [23] reported that the procedure of one-stage posterior transforaminal debridement, interbody fusion and instrumentation achieved a good result for lumbosacral junction tuberculosis. In our study, we performed debridement via the intervertebral space by taking the paramedial approach rather than the transforaminal approach, because we have experience with this approach and we can reach the intervertebral space easily on both sides, remove debris, insert the graft and correct the deformity. In this study, only one patient relapsed. We believe the success of debridement by this procedure was due to our strict selection of patients and our proficient posterior spinal skills. This procedure is not suitable for patients with extensive paravertebral abscesses or flow abscesses.
The following are some notes on this technique. First, there is no problem of dura avulsion [24]. Due to the narrow space of debridement, the risk of dura laceration is theoretically higher. In our study, there were six cases of dura laceration. All patients were healed by fluid infusion and relevant management (the dura was sutured in three patients), and there was no spread of infection or secondary intracranial infection. We suggest that if dura tear occurs it should be sutured if possible during the operation. If the dura cannot be sutured, the deep fascia must be rigid sutured. Remember to remove the drainage tube as quickly as possible and suture the drainage entrance deeply. Second, decrease the traction on the neural root. When we remove the pathologic sclerotic bone and the paravertebral abscess, it is hard to avoid traction and irritation of the neural root. Our experience is that preoperative preparation with spatulas of various angles, osteotomes and high-speed drills is essential for this operation. During the operation, the surgeon needs to be gentle. If the lesion is difficult to deal with ipsilaterally, it can be approached on the contralateral side in the intervertebral space. Third, protect the anterior longitudinal ligament when clearing the paravertebral abscess. If the abscess is too viscous, high-pressure washing should be used [25]. Rough surgical techniques on the anterior side of the vertebrae with no visual confirmation are forbidden. Fourth, use the combined structural and granulated bone impaction grafting method for intervertebral bone grafting to decrease the risk of neural injury and increase the efficacy of bone fusion [26].
Conclusions
Transintervertebral space debridement with annular bone graft fusion and fixation through a single posterior approach is a good treatment for lumbosacral junction tuberculosis because of its effective debridement, bone grafting and fixation.
Anzeige
Acknowledgements
Not applicable.
Funding
This study was funded by China Xi’an Science and Technology Projects (2017115SF/YX009(3)) and Shaanxi Provincial Science and Technology Projects (2017JM8129).
Availability of data and materials
The datasets supporting the conclusions of this article are included within the article. The raw data can be requested from the corresponding author on reasonable request.
Ethics approval and consent to participate
Ethical approval from the Ethics Committee of the Shaanxi Provincial People’s Hospital was obtained for this study. Each author certifies that all investigations were conducted in conformity with ethical principles.
Anzeige
Consent for publication
All patients signed informed consent forms to publish their personal details in this article.
Competing interests
The authors declare that they have no competing interests.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Dr. med. Mihailo Andric Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
