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Erschienen in: International Journal of Colorectal Disease 5/2017

11.03.2017 | Original Article

Postoperative ileus in an enhanced recovery pathway—a retrospective cohort study

verfasst von: Fabian Grass, Juliette Slieker, Jonas Jurt, Anne Kummer, Josep Solà, Dieter Hahnloser, Nicolas Demartines, Martin Hübner

Erschienen in: International Journal of Colorectal Disease | Ausgabe 5/2017

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Abstract

Purpose

Enhanced recovery after surgery (ERAS) protocols advocate no nasogastric tubes after colorectal surgery, but postoperative ileus (POI) remains a challenging clinical reality. The aim of this study was to assess incidence and risk factors of POI.

Methods

This retrospective analysis included all consecutive colorectal surgical procedures since May 2011 until November 2014. Uni- and multivariate risk factors for POI were identified by multiple logistic regression and functional and surgical outcomes assessed.

Results

The study cohort consisted of 513 consecutive colorectal ERAS patients. One hundred twenty-eight patients (24.7%) needed postoperative reinsertion of nasogastric tube at the 3.9 ± 2.9 postoperative day. Multivariate analysis retained the American Society of Anesthesiologists group 3–4 (odds ratio (OR) 1.3; 95% CI 1–1.8, p = 0.043) and duration of surgery of >3 h (OR 1.3; 95% CI 1–1.7, p = 0.047) as independent risk factors for POI. Minimally invasive surgery (OR 0.6; 95% CI 0.5–0.8, p ≤ 0.001) and overall compliance of >70% to the ERAS protocol (OR 0.7; 95% CI 0.6–1, p = 0.031) represented independent protective factors. POI was associated with respiratory (23 vs. 5%, p ≤ 0.001) and cardiovascular (16 vs. 3%, p ≤ 0.001) complications.

Conclusions

POI was frequent in the present study. Overall compliance to the ERAS protocol and minimally invasive surgery helped to prevent POI, which was significantly correlated with medical complications.
Literatur
1.
Zurück zum Zitat Su’a BU, Hill AG (2015) Perioperative use of chewing gum affects the inflammatory response and reduces postoperative ileus following major colorectal surgery. Evidence-based medicine 20(5):185–186CrossRefPubMed Su’a BU, Hill AG (2015) Perioperative use of chewing gum affects the inflammatory response and reduces postoperative ileus following major colorectal surgery. Evidence-based medicine 20(5):185–186CrossRefPubMed
2.
Zurück zum Zitat Ahmed Ali U, Dunne T, Gurland B, Vogel JD, Kiran RP (2014) Actual versus estimated length of stay after colorectal surgery: which factors influence a deviation? Am J Surg 208(4):663–669CrossRefPubMed Ahmed Ali U, Dunne T, Gurland B, Vogel JD, Kiran RP (2014) Actual versus estimated length of stay after colorectal surgery: which factors influence a deviation? Am J Surg 208(4):663–669CrossRefPubMed
3.
Zurück zum Zitat Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, McNaught CE, Macfie J, Liberman AS, Soop M et al (2013) Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. World J Surg 37(2):259–284CrossRefPubMed Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, McNaught CE, Macfie J, Liberman AS, Soop M et al (2013) Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. World J Surg 37(2):259–284CrossRefPubMed
4.
Zurück zum Zitat Gustafsson UO, Hausel J, Thorell A, Ljungqvist O, Soop M, Nygren J (2011) Enhanced recovery after surgery study Group: adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery. Arch Surg 146(5):571–577CrossRefPubMed Gustafsson UO, Hausel J, Thorell A, Ljungqvist O, Soop M, Nygren J (2011) Enhanced recovery after surgery study Group: adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery. Arch Surg 146(5):571–577CrossRefPubMed
5.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Greco M, Capretti G, Beretta L, Gemma M, Pecorelli N, Braga M (2014) Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials. World J Surg 38(6):1531–1541CrossRefPubMed Greco M, Capretti G, Beretta L, Gemma M, Pecorelli N, Braga M (2014) Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials. World J Surg 38(6):1531–1541CrossRefPubMed
7.
Zurück zum Zitat Roulin D, Donadini A, Gander S, Griesser AC, Blanc C, Hubner M, Schafer M, Demartines N (2013) Cost-effectiveness of the implementation of an enhanced recovery protocol for colorectal surgery. Br J Surg 100(8):1108–1114CrossRefPubMed Roulin D, Donadini A, Gander S, Griesser AC, Blanc C, Hubner M, Schafer M, Demartines N (2013) Cost-effectiveness of the implementation of an enhanced recovery protocol for colorectal surgery. Br J Surg 100(8):1108–1114CrossRefPubMed
8.
Zurück zum Zitat Roulin D, Blanc C, Muradbegovic M, Hahnloser D, Demartines N, Hubner M (2014) Enhanced recovery pathway for urgent colectomy. World J Surg 38(8):2153–2159CrossRefPubMed Roulin D, Blanc C, Muradbegovic M, Hahnloser D, Demartines N, Hubner M (2014) Enhanced recovery pathway for urgent colectomy. World J Surg 38(8):2153–2159CrossRefPubMed
9.
Zurück zum Zitat Vather R, Josephson R, Jaung R, Kahokehr A, Sammour T, Bissett I (2015) Gastrografin in prolonged postoperative ileus: a double-blinded randomized controlled trial. Ann Surg 262(1):23–30CrossRefPubMed Vather R, Josephson R, Jaung R, Kahokehr A, Sammour T, Bissett I (2015) Gastrografin in prolonged postoperative ileus: a double-blinded randomized controlled trial. Ann Surg 262(1):23–30CrossRefPubMed
10.
Zurück zum Zitat Moghadamyeghaneh Z, Hwang GS, Hanna MH, Phelan M, Carmichael JC, Mills S, Pigazzi A, Stamos MJ 2015: Risk factors for prolonged ileus following colon surgery. Surgical endoscopy. Moghadamyeghaneh Z, Hwang GS, Hanna MH, Phelan M, Carmichael JC, Mills S, Pigazzi A, Stamos MJ 2015: Risk factors for prolonged ileus following colon surgery. Surgical endoscopy.
11.
Zurück zum Zitat Iyer S, Saunders WB, Stemkowski S (2009) Economic burden of postoperative ileus associated with colectomy in the United States. Journal of Managed Care Pharmacy : JMCP 15(6):485–494CrossRefPubMed Iyer S, Saunders WB, Stemkowski S (2009) Economic burden of postoperative ileus associated with colectomy in the United States. Journal of Managed Care Pharmacy : JMCP 15(6):485–494CrossRefPubMed
12.
Zurück zum Zitat Wolthuis AM, Bislenghi G, Fieuws S, de Buck van Overstraeten A, Boeckxstaens G, D’Hoore A (2016) Incidence of prolonged postoperative ileus after colorectal surgery: a systematic review and meta-analysis. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 18(1):O1–O9CrossRef Wolthuis AM, Bislenghi G, Fieuws S, de Buck van Overstraeten A, Boeckxstaens G, D’Hoore A (2016) Incidence of prolonged postoperative ileus after colorectal surgery: a systematic review and meta-analysis. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 18(1):O1–O9CrossRef
13.
Zurück zum Zitat Bragg D, El-Sharkawy AM, Psaltis E, Maxwell-Armstrong CA, Lobo DN (2015) Postoperative ileus: recent developments in pathophysiology and management. Clin Nutr 34(3):367–376CrossRefPubMed Bragg D, El-Sharkawy AM, Psaltis E, Maxwell-Armstrong CA, Lobo DN (2015) Postoperative ileus: recent developments in pathophysiology and management. Clin Nutr 34(3):367–376CrossRefPubMed
14.
Zurück zum Zitat Vlug MS, Bartels SA, Wind J, Ubbink DT, Hollmann MW, Bemelman WA, Collaborative LSG (2012) Which fast track elements predict early recovery after colon cancer surgery? Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 14(8):1001–1008CrossRef Vlug MS, Bartels SA, Wind J, Ubbink DT, Hollmann MW, Bemelman WA, Collaborative LSG (2012) Which fast track elements predict early recovery after colon cancer surgery? Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 14(8):1001–1008CrossRef
15.
Zurück zum Zitat Gillis C, Li C, Lee L, Awasthi R, Augustin B, Gamsa A, Liberman AS, Stein B, Charlebois P, Feldman LS et al (2014) Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology 121(5):937–947CrossRefPubMed Gillis C, Li C, Lee L, Awasthi R, Augustin B, Gamsa A, Liberman AS, Stein B, Charlebois P, Feldman LS et al (2014) Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology 121(5):937–947CrossRefPubMed
16.
Zurück zum Zitat Kiran RP, Murray AC, Chiuzan C, Estrada D, Forde K (2015) Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery. Ann Surg 262(3):416–425CrossRefPubMed Kiran RP, Murray AC, Chiuzan C, Estrada D, Forde K (2015) Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery. Ann Surg 262(3):416–425CrossRefPubMed
17.
Zurück zum Zitat Short V, Herbert G, Perry R, Atkinson C, Ness AR, Penfold C, Thomas S, Andersen HK, Lewis SJ (2015) Chewing gum for postoperative recovery of gastrointestinal function. The Cochrane database of systematic reviews 2:CD006506 Short V, Herbert G, Perry R, Atkinson C, Ness AR, Penfold C, Thomas S, Andersen HK, Lewis SJ (2015) Chewing gum for postoperative recovery of gastrointestinal function. The Cochrane database of systematic reviews 2:CD006506
18.
Zurück zum Zitat Sun Y, Li T, Wang N, Yun Y, Gan TJ (2012) Perioperative systemic lidocaine for postoperative analgesia and recovery after abdominal surgery: a meta-analysis of randomized controlled trials. Dis Colon rectum 55(11):1183–1194CrossRefPubMed Sun Y, Li T, Wang N, Yun Y, Gan TJ (2012) Perioperative systemic lidocaine for postoperative analgesia and recovery after abdominal surgery: a meta-analysis of randomized controlled trials. Dis Colon rectum 55(11):1183–1194CrossRefPubMed
19.
Zurück zum Zitat Adam MA, Lee LM, Kim J, Shenoi M, Mallipeddi M, Aziz H, Stinnett S, Sun Z, Mantyh CR, Thacker JK (2015) Alvimopan provides additional improvement in outcomes and cost savings in enhanced recovery colorectal surgery. Annals of surgery. Adam MA, Lee LM, Kim J, Shenoi M, Mallipeddi M, Aziz H, Stinnett S, Sun Z, Mantyh CR, Thacker JK (2015) Alvimopan provides additional improvement in outcomes and cost savings in enhanced recovery colorectal surgery. Annals of surgery.
20.
Zurück zum Zitat Gero D, Gie O, Hubner M, Demartines N, Hahnloser D 2016: Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment. Langenbeck’s archives of surgery/Deutsche Gesellschaft fur Chirurgie. Gero D, Gie O, Hubner M, Demartines N, Hahnloser D 2016: Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment. Langenbeck’s archives of surgery/Deutsche Gesellschaft fur Chirurgie.
Metadaten
Titel
Postoperative ileus in an enhanced recovery pathway—a retrospective cohort study
verfasst von
Fabian Grass
Juliette Slieker
Jonas Jurt
Anne Kummer
Josep Solà
Dieter Hahnloser
Nicolas Demartines
Martin Hübner
Publikationsdatum
11.03.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Colorectal Disease / Ausgabe 5/2017
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-017-2789-5

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