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27.04.2016 | Natural Resource Letter

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

verfasst von: Ahmed R. Hamed, Mohamed-Elamir F. Hegazy, Maureen Higgins, Tarik A. Mohamed, Nahla S. Abdel-Azim, Paul W. Pare, Albena T. Dinkova-Kostova

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2016

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Abstract

Medicinal plants from the Egyptian Sinai Peninsula are widely used in traditional Bedouin medicine to treat a range of conditions including cancer, and as such are a promising resource for novel anti-cancer compounds. To achieve scientific justification of traditional use and/or to recommend the use of those plants as medicinal herbs for cancer chemoprevention, a group of 11 Sinai plants of different species that belong to 3 families (Asteraceae, Lamiaceae, and Euphorbiaceae) were biologically screened for cancer preventive activity using the chemoprevention marker enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). Among the fractions assayed, a solvent extract from Pulicaria incisa had potent NQO1 inducing activity. Further analysis of the mechanism of induction revealed the concentration-dependent stabilization of the transcription factor NF-E2 p45-related factor 2 (Nrf2) and a coordinate upregulation of the Nrf2-dependent enzymes NQO1, heme oxygenase 1 and glutathione S-transferase-Pi. These results establish P. incisa as a promising target for future phytochemical characterization for cancer preventive components.

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Titel: Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1
verfasst von: Ahmed R. Hamed
Mohamed-Elamir F. Hegazy
Maureen Higgins
Tarik A. Mohamed
Nahla S. Abdel-Azim
Paul W. Pare
Albena T. Dinkova-Kostova
Publikationsdatum: 27.04.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-0994-0

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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