Introduction
Materials and methods
Animals
Antigen-induced arthritis
mRNA microarray analysis
Treatment protocol and drugs
Pain-related behavior and clinical inflammation measurement
Histopathological grading of joint inflammation and destruction
Statistical analyses
Results
Effects of endothelin receptor antagonists on antigen-induced arthritis
Illumina ID | Gene | Synonym | Fold change |
---|---|---|---|
scl0011829.2_75-S |
AQP4
a
| Aquaporin 4 | 9 |
scl27591.6.1_80-S |
AREG
a
| Amphiregulin | 10 |
scl27547.3.1_4-S |
BMP3
| Bone morphogenetic protein 3 | 8 |
scl26388.10_270-S |
BTC
| Betacellulin | 5 |
scl026365.2_7-S |
CEACAM1
| Carcinoembryonic antigen-related cell adhesion molecule | 13 |
scl0023844.2_19-S |
CLCA3
| Ca2+-activated chloride channel | 1,724 |
scl020312.5_187-S |
CX3CL1
a
| Chemokine (C-X3-C motif) ligand 1 | 6 |
scl48937.1.1_21-S |
CXADR
| Coxackie and adenovirus receptor | 15 |
scl31983.48.1_26-S |
DMBT1
| Deleted in malignant brain tumors | 678 |
scl44852.5.1_6-S |
EDN1
a
| Endothelin 1 | 16 |
scl25019.5.1_161-S |
EDN2
| Endothelin 2 | 5 |
scl15480.1.1_277-S |
EDNRA
a
| Endothelin receptor A | 7 |
scl45193.8_18-S |
EDNRB
| Endothelin receptor B | 1 |
scl0001767.1_56-S |
FAM3B
| Family with sequence similarity 3, member B | 10 |
scl43662.2_474-S |
F2RL1
| F2RL1 coagulation factor II receptor-like 1 | 28 |
scl48150.3.1_29-S |
FAM3D
| Family with sequence similarity 3, member D | 18 |
scl47093.2_645-S |
GPR20
| G protein-coupled receptor 20 | 22 |
scl53162.3.1_182-S |
GPR120
| G protein-coupled receptor 120 | 6 |
scl0232431.4_71-S |
GPRC5A
| G protein-coupled receptor, family C, group 5, member A | 62 |
scl25025.4.1_56-S |
GUCA2A
| Guanylin | 802 |
scl016173.8_28-S |
IL18
a
| Interleukin 18 | 6 |
scl49177.8_486-S |
ILDR1
| Ig-like domain-containing receptor 1 | 26 |
scl016612.5_71-S |
KLK1
a
| Kallikrein 1 | 113 |
GI_6754459-S |
KLK1B26
| Kallikrein 1-related peptidase b26 | 112 |
scl018050.1_7-S |
KLK1B4
| Kallikrein 1-related peptidase b4 | 127 |
scl000139.1_0-S |
KLK1B5
| Kallikrein 1-related peptidase b5 | 302 |
scl0016619.1_79-S |
KLK3
| Kallikrein 1-related peptidase b27 | 121 |
scl49904.15_203-S |
MEP1A
| Meprin A, alpha | 20 |
scl48741.4.1_176-S |
PLA2G4F
a
| Phospholipase A2 | 93 |
scl39519.5.1_59-S |
PYY
| Peptide YY | 72 |
scl16482.8_0-S |
RAB17
| Member of RAS oncogene family | 9 |
scl24993.3_35-S |
RHBDL2
| Rhomboid, veinlet-like 2 | 5 |
scl22946.3.1_72-S |
S100A14
a
| S100 calcium-binding protein | 55 |
scl32104.13.1_7-S |
SCNN1B
| Na-channel, nonvoltage-gated 1, beta-subunit | 7 |
scl30493.4.19_120-S |
SCT
a
| Secretin | 9 |
scl20135.8.1_22-S |
SDCBP2
| Syndecan-binding protein (syntenin) 2 | 41 |
scl026456.19_173-S |
SEMA4G
| Semaphorin 4G | 9 |
scl0020510.2_224-S |
SLC1A1
| Solute carrier family 1, member 1 | 5 |
scl32784.15.1_26-S |
SLC7A9
| Solute carrier family 7, member 9 | 11 |
scl00226999.1_58-S |
SLC9A2
| Solute carrier family 9, member 2 | 31 |
scl00171286.2_214-S |
SLC12A8
| Solute carrier family 12, member 8 | 16 |
scl39885.12.1_61-S |
SLC13A2
| Solute carrier family 13, member 2 | 47 |
scl47037.12.1_89-S |
SLC39A4
| Solute carrier family 39, member 4 | 16 |
scl41202.6.1_16-S |
SLC46A1
a
| Solute carrier family 46, member 1 | 5 |