Introduction
Blood-based biomarkers
Biomarkers | Sensitivity (%) | Specificity (%) |
---|---|---|
CA 19-9 (up to 1 year prior to diagnosis) [7] | 68 | 95 |
CA 19-9 (between 1 and 2 years prior to diagnosis) [7] | 53 | 95 |
CA 19-9 + CA125 (up to 1 year prior to diagnosis) [7] | 57.1 | 90 |
MIC-1 [8] | 94 | 45.8 |
ADH [8] | 62 | 83.3 |
Osteonectin [9] | 84.6 | 87.5 |
IGFBP2 [10] | 68.4 | 67.7 |
IGFBP3 [10] | 76.3 | 70.7 |
Glypican-1 positive exosomes [12] | 100 | 100 |
Apo-AII ATQ/AT + CA 19-9 [11] | 95.4 | 98.3 |
TFPI + TNC + CA 19-9 [13] | 76 | 84 |
TFF1 + TFF2 + TFF3 [14] | 73 | 54 |
TFF1 + TFF2 + TFF3 + CA 19-9 [14] | 85 | 92 |
Antibody microarray (29 markers) [15] | 95 | 94 |
Serum electrospray mass profiling [16] | 95 | 96 |
Protein corona-based test [17] | 85 | 100 |
Autoantibodies against TAA [18] | 50 | 90 |
Biomarkers | Sensitivity (%) | Specificity (%) |
---|---|---|
Model X (1,5-AG, histidine, inositol, and xylitol) [19] | 74.1 | 86 |
Model Y (histidine and xylitol) [19] | 70.4 | 89.5 |
Model Y + CA 19-9 [19] | 90.7 | 89.5 |
5-Hydroxytryptophan + LysoPE(18:2) + PC(16:0/16:0) + PC(18:0/22:4) + PE(17:0/0:0) + SM(d18:1/16:0) [20] | 90 | 85 |
Biomarkers | Sensitivity (%) | Specificity (%) |
---|---|---|
KRAS exoDNA [21] | 75.4 | 92.6 |
HYAL2A methylation [22] | 75.6 | 93.7 |
2 miRNA panel [23] | 79 | 85 |
PaCIC + miRNA [24] | 100 | 80 |
7-lncRNA signature [25] | 84 | 57.1 |
Biomarkers | Sensitivity (%) | Specificity (%) |
---|---|---|
CancerSEEK [26] | 72 | 99 |