Background
Methods
Study subjects
Epidemiological survey
Biochemical analyses
Sample preparation and genotyping
Statistical analyses
Results
Population characteristics and metabolic measures
Parameter | LG (n = 487) | OG (n = 593) | CG (n = 582) |
F(χ
2
)
|
P
|
---|---|---|---|---|---|
Age (years) | 93.28 ± 2.87*▲
| 58.35 ± 9.06 | 58.18 ± 9.77 | 3239.680 | 0.000 |
Male/Female | 200/287 | 333/260 | 328/254 | 31.813 | 0.000 |
WC (cm) | 76.23 ± 9.14 | 75.08 ± 9.27 | 75.53 ± 9.41 | 0.340 | 0.712 |
BMI (kg/m2) | 20.21 ± 3.63 | 21.68 ± 3.00 | 21.69 ± 3.24 | 0.022 | 0.978 |
FPG (mmol/L) | 4.65 ± 1.18▲
| 4.97 ± 1.80* | 4.73 ± 1.52 | 8.070 | 0.000 |
SBP (mm Hg) | 165.83 ± 26.15 | 137.81 ± 22.96 | 136.02 ± 23.56 | 0.618 | 0.539 |
DBP (mm Hg) | 89.21 ± 13.17*▲
| 85.15 ± 11.22 | 84.68 ± 11.31 | 4.020 | 0.018 |
PP (mm Hg) | 76.61 ± 23.74 | 52.66 ± 19.81 | 51.34 ± 18.40 | 2.484 | 0.084 |
TC (mmol/L) | 5.09 ± 1.00* | 5.31 ± 1.13* | 4.88 ± 1.00 | 28.690 | 0.000 |
TG (mmol/L) | 0.97(0.45) | 1.00(0.89) | 0.95(0.66) | 2.150 | 0.117 |
HDL-C (mmol/L) | 1.61 ± 0.53 | 1.71 ± 0.57* | 1.62 ± 0.50 | 3.353 | 0.035 |
LDL-C (mmol/L) | 2.99 ± 0.87* | 2.99 ± 1.04* | 2.61 ± 0.92 | 27.325 | 0.000 |
Genetic distribution
Genotypes and metabolic risk factors
Correlation analyses
Parameter | Relative factor | Unstandardized coefficients | Standard error | Standardized coefficients |
t
|
P
|
---|---|---|---|---|---|---|
LG | ||||||
BMI | WC | 0.118 | 0.020 | 0.296 | 5.924 | 0.000 |
HC | 0.184 | 0.025 | 0.342 | 7.333 | 0.000 | |
DBP | −0.498 | 0.227 | −0.072 | −2.193 | 0.029 | |
FBG | Sex | 0.353 | 0.106 | 0.147 | 3.326 | 0.001 |
TG | 0.391 | 0.122 | 0.143 | 3.217 | 0.001 | |
WC | 0.012 | 0.006 | 0.093 | 2.094 | 0.037 | |
SBP | Sex | 4.815 | 2.401 | 0.091 | 2.005 | 0.045 |
DBP | TC | 1.879 | 0.586 | 0.143 | 3.208 | 0.001 |
BMI | 0.484 | 0.162 | 0.133 | 2.995 | 0.003 | |
PP | - | - | - | - | - | - |
TC | DBP | 0.011 | 0.003 | 0.139 | 3.146 | 0.002 |
Sex | 0.223 | 0.091 | 0.110 | 2.445 | 0.015 | |
FBG | 0.088 | 0.038 | 0.103 | 2.306 | 0.022 | |
Genotype | −0.132 | 0.063 | −0.093 | −2.090 | 0.037 | |
TG | FBG | 0.058 | 0.016 | 0.159 | 3.556 | 0.000 |
DBP | 0.004 | 0.001 | 0.108 | 2.425 | 0.016 | |
HDL-C | BMI | −0.015 | 0.007 | −0.105 | −2.336 | 0.020 |
LDL-C | DBP | 0.009 | 0.003 | 0.131 | 2.930 | 0.004 |
Sex | 0.230 | 0.079 | 0.131 | 2.921 | 0.004 | |
OG | ||||||
BMI | WC | 0.090 | 0.037 | 0.054 | 2.427 | 0.016 |
Sex | 0.730 | 0.144 | 0.121 | 5.062 | 0.000 | |
DBP | 0.040 | 0.006 | 0.148 | 6.502 | 0.000 | |
Age | 0.171 | 0.067 | 0.059 | 2.554 | 0.011 | |
FBG | WC | −0.041 | 0.011 | −0.173 | −3.691 | 0.000 |
DBP | −0.649 | 0.131 | −0.205 | −4.952 | 0.000 | |
SBP | Age | 0.902 | 0.096 | 0.356 | 9.377 | 0.000 |
BMI | 1.522 | 0.290 | 0.199 | 5.251 | 0.000 | |
Sex | −4.215 | 1.751 | −0.091 | −2.407 | 0.016 | |
DBP | BMI | 1.669 | 0.172 | 0.447 | 9.717 | 0.000 |
Sex | −4.944 | 0.838 | −0.219 | −5.897 | 0.000 | |
HC | −0.924 | 0.421 | −0.085 | −2.197 | 0.028 | |
FBG | −0.651 | 0.235 | −0.105 | −2.767 | 0.006 | |
PP | Age | 0.859 | 0.083 | 0.393 | 10.389 | 0.000 |
TC | WC | −0.037 | 0.013 | −0.213 | −2.911 | 0.004 |
Age | −0.013 | 0.005 | −0.105 | −2.670 | 0.008 | |
BMI | 0.069 | 0.027 | 0.182 | 2.588 | 0.010 | |
DBP | −0.008 | 0.004 | −0.084 | −2.065 | 0.039 | |
TG | WC | 0.057 | 0.011 | 0.353 | 5.282 | 0.000 |
Sex | −0.076 | 0.033 | −0.151 | −2.287 | 0.023 | |
HDL-C | WC | −0.012 | 0.002 | −0.189 | −4.676 | 0.000 |
Sex | 0.115 | 0.045 | 0.100 | 2.543 | 0.011 | |
LDL-C | BMI | 0.113 | 0.014 | 0.328 | 7.871 | 0.000 |
DBP | −0.012 | 0.004 | −0.125 | −2.996 | 0.003 | |
CG | ||||||
BMI | WC | 0.151 | 0.025 | 0.278 | 5.998 | 0.000 |
Age | 0.247 | 0.079 | 0.084 | 3.123 | 0.002 | |
FBG | WC | 0.186 | 0.055 | 0.137 | 3.359 | 0.001 |
SBP | Age | −4.021 | 1.801 | −0.086 | −2.232 | 0.026 |
HC | 0.706 | 0.152 | 0.181 | 4.631 | 0.000 | |
DBP | Sex | 0.541 | 0.142 | 0.157 | 3.822 | 0.000 |
FBG | −0.650 | 0.305 | −0.087 | −2.133 | 0.033 | |
PP | Age | −3.783 | 1.391 | −0.104 | −2.720 | 0.007 |
HC | 0.429 | 0.114 | 0.141 | 3.751 | 0.000 | |
Sex | 4.185 | 1.404 | 0.113 | 2.980 | 0.003 | |
TC | BMI | 0.045 | 0.020 | 0.149 | 2.310 | 0.021 |
Age | −0.015 | 0.004 | −0.143 | −3.320 | 0.001 | |
CC | −0.040 | 0.011 | −0.275 | −3.737 | 0.000 | |
WC | 0.026 | 0.008 | 0.243 | 3.117 | 0.002 | |
TG | BMI | 0.076 | 0.021 | 0.223 | 3.586 | 0.000 |
Age | −0.027 | 0.005 | −0.233 | −5.740 | 0.000 | |
FBG | 0.096 | 0.029 | 0.131 | 3.270 | 0.001 | |
HC | −0.058 | 0.013 | −0.315 | −4.616 | 0.000 | |
WC | 0.029 | 0.009 | 0.246 | 3.365 | 0.001 | |
HDL-C | Sex | −0.003 | 0.001 | −0.108 | −2.688 | 0.007 |
WC | −0.008 | 0.002 | −0.154 | −3.827 | 0.000 | |
LDL-C | WC | 0.012 | 0.004 | 0.120 | 2.914 | 0.004 |