Background
Methods
Patients and data collection
Serological testing
G test
GM test
Aspergillus IgG
Aspergillus IgM
Statistical analysis
Results
Patient characteristics
characteristics | No. of patients (n = 58) | % |
---|---|---|
Gender | ||
Male | 36 | 62.07 |
Female | 22 | 37.93 |
Age | ||
≥ 60 | 32 | 55.17 |
< 60 | 26 | 44.83 |
Case classification | ||
IPA | 37 | 63.79 |
CPA | 21 | 36.21 |
Underlying disease | ||
chronic respicatory disease | 26 | 44.83 |
Organ failure | 1 | 1.72 |
Chronic cardiovascular disease | 5 | 8.62 |
pulmonary tuberculosis | 4 | 6.90 |
chronic liver disease | 1 | 1.72 |
Diabetes | 15 | 25.86 |
Autoimmune disease | 1 | 1.72 |
Others | 8 | 13.79 |
No underlying disease | 7 | 12.07 |
Characteristics comparison between IPA and CPA cases
Characteristics | IPA (n = 37) | CPA (n = 21) | Overall (n = 58) | P |
---|---|---|---|---|
Ratio of male to female patients | 23:14 | 13:8 | 36:22 | 0.985 |
Age, median years | 64 (54.513, 72) | 60 (46.524, 66) | 64 (53.753, 70.248) | 0.128 |
Course of disease (median, day) | 17 (10, 30) | 75 (23.251, 187.532) | 20 (13, 60) | < 0.001 |
Microbiological findings | ||||
Staphylococcus aureus | 1 (2.703) | 0 | 1 (1.724) | 1.000 |
Pseudomonas aeruginosa | 1 (2.703) | 1 (4.762) | 2 (3.448) | 1.000 |
Candida albicans | 1 (2.703) | 1 (4.762) | 2 (3.448) | 1.000 |
Acinstobacter baumannii | 1 (2.703) | 1 (4.762) | 2 (3.448) | 1.000 |
Klebsiella pneumoniae | 2 (5.405) | 0 | 2 (3.448) | 0.530 |
Aspergillus | 8 (21.622) | 3 (14.286) | 11 (18.966) | 0.301 |
Others | 2 (5.405) | 1 (4.762) | 3 (5.172) | 1.000 |
Clinical symptoms, n(%) | ||||
Cough | 34 (91.892) | 18 (85.714) | 52 (89.655) | 0.657 |
Fever (> 38 °C) | 22 (59.459) | 3 (14.286) | 25 (43.103) | 0.001 |
Dyspnoea | 25 (67.568) | 8 (38.095) | 33 (56.897) | 0.029 |
Haemoptysis | 13 (35.135) | 13 (61.905) | 26 (44.828) | 0.049 |
Chest Pain | 8 (21.622) | 2 (9.524) | 10 (17.241) | 0.301 |
Expectoration | 33 (89.189) | 17 (80.952) | 50 (86.207) | 0.443 |
Thoracic CT signs, n(%) | ||||
Patchy exudate shadows | 36 (97.297) | 11 (52.381) | 47 (81.034) | < 0.001 |
Nodules | 19 (51.351) | 9 (42.857) | 28 (48.276) | 0.534 |
segmental areas of consolidation | 4 (10.811) | 7 (33.333) | 11(18.966) | 0.077 |
Cavity | 17 (45.946) | 14 (66.667) | 31 (53.448) | 0.128 |
Pleural effusion | 11 (29.730) | 2 (9.524) | 13 (22.414) | 0.106 |
Air crescent sign | 2 (5.405) | 9 (42.857) | 11 (18.966) | 0.001 |
ground-glass attenuation | 22 (59.459) | 5 (23.810) | 27 (46.552) | 0.009 |
other | 1 (2.703) | 13 (61.905) | 14 (24.138) | < 0.001 |
Involving lobes of lung, n(%) | ||||
Right upper lobe | 28 (75.676) | 13 (61.905) | 41 (70.689) | 0.268 |
Right middle lobe | 24 (64.865) | 3 (14.286) | 27 (46.552) | < 0.001 |
Right lower lobe | 30 (81.081) | 9 (42.857) | 39 (67.241) | 0.003 |
Left upper lobe | 28 (75.676) | 7 (33.333) | 35 (60.345) | 0.002 |
Left lower lobe | 27 (72.973) | 12 (57.143) | 39 (67.241) | 0.217 |
Serum indexs | ||||
Erythrocyte sedimentation rate (mm/h) | 46 (26.515, 62) | 30 (19.525, 55) | 42 (25.514, 60.543) | 0.369 |
White blood cell count (109cells/L) | 8.77 (5.534, 13.495) | 6.97 (5.862, 8.471) | 7.96 (5.788, 12.163) | 0.212 |
Neutrophil count (109cells/L) | 7.3 (3.555, 11.205) | 4.31 (3.475, 6.685) | 5.31 (3.495, 9.945) | 0.083 |
Eosinophilia count (109cells/L) | 0.07 (0.005, 0.135) | 0.1 (0.035, 0.223) | 0.085 (0.012, 0.153) | 0.104 |
Monocyte count (109cells/L) | 0.45 (0.325, 0.57) | 0.57 (0.385, 0.695) | 0.49 (0.348, 0.603) | 0.113 |
Platelet ((109cells/L)) | 273 (199.5385.5) | 257 (209,294.5) | 263.5 (208.75, 336.25) | 0.257 |
Serum ALT level (U/L) | 21.8 (15.65, 41.55) | 20.2 (13.9, 30.4) | 21.65 (15.425, 34.775) | 0.32 |
Serum creatinine level (μmol/L) | 67 (53.75, 78.75) | 67 (60, 77.5) | 67 (59, 78) | 0.715 |
Serum albumin level (g/L) | 36.2 (28.725, 41) | 42.8 (39.5, 44.95) | 40.4 (35.6, 43.9) | <0.001 |
Serum LDH level (U/L) | 262 (203, 373.5) | 225 (187.5, 236.5) | 233.5 (198, 326.75) | 0.025 |
Serum CRP level (mg/L) | 4.09 (1.135, 11) | 1.7 (0.485, 7.335) | 2.85 (0.538, 8.615) | 0.174 |
PCT (ng/ml) | 0.09 (0.050, 0.215) | 0.05 (0.05, 0.063) | 0.05 (0.05, 0.15) | 0.007 |
Lymphocyte count (109cells/L) | 1.455 ± 0.63 | 1.890 ± 0.577 | 1.685 ± 0.639 | < 0.001 |
Results of serum G test, GM test, and Aspergillus IgG and IgM antibody detection in each group
Group | G test positive n (%) | Aspergillus IgG antibody positive n (%) | Aspergillus IgM antibody positive n (%) | GM test positive n (%) |
---|---|---|---|---|
pulmonary aspergillosis group | 14 (24.138) | 33 (56.897) | 14 (24.138) | 12 (20.690) |
bacterial pneumonia group | 1 (6.667) | 3 (20.00) | 4 (26.667) | 2 (13.333) |
healthy group | 3 (6.000) | 8 (16.000) | 9 (18.000) | 4 (8.000) |
P | 0.015 | < 0.001 | 0.649 | 0.198 |
Group | G test positive n (%) | Aspergillus IgG antibody positive n (%) | Aspergillus IgM antibody positive n (%) | GM test positive n (%) |
---|---|---|---|---|
IPA group | 12 (32.430) | 18 (48.650) | 6 (16.220) | 11 (29.730) |
CPA group | 2 (9.523) | 15 (71.429) | 8 (38.095) | 1 (4.762) |
bacterial pneumonia group | 1 (6.667) | 3 (20.000) | 4 (26.667) | 2 (13.333) |
healthy group | 3 (6.000) | 8 (16.000) | 9 (18.000) | 4 (8.000) |
P | 0.006 | < 0.001 | 0.217 | 0.022 |
Group | G test positive n (%) | Aspergillus IgG antibody positive n (%) | Aspergillus IgM antibody positive n (%) | GM test positive n (%) |
---|---|---|---|---|
IPA group | 12 (32.432) | 18 (48.649) | 6 (16.216) | 11 (29.730) |
CPA group | 2 (9.523) | 15 (71.429) | 8 (38.095) | 1 (4.762) |
P | 0.050 | 0.092 | 0.061 | 0.040 |