Skip to main content

10.08.2019 | Brief Report | Ausgabe 2/2020

Virchows Archiv 2/2020

Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma

Virchows Archiv > Ausgabe 2/2020
Stefan Porubsky, Peter Jessup, Damien Kee, Rajiv Sharma, Ayame Ochi, Huiling Xu, Jens J. Froelich, Louise Nott, Clare Scott, Raef Awad, Cristina Moldovan, Ashutosh A. Hardikar, Hanibal Bohnenberger, Stefan Küffer, Philipp Ströbel, Alexander Marx
Wichtige Hinweise

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 thymic carcinomas for the presence of sebaceous differentiation as defined by morphology and expression of adipophilin and androgen receptor (AR). One primary thymic carcinoma showed morphology of sebaceous carcinomas (keratinizing and foam cells, calcifications, giant cells), a strong expression of adipophilin and AR together with squamous markers. NGS revealed high-level amplification of fibroblast growth factor receptor 2 (FGFR2). In thymuses and thymomas, no cells with sebaceous morphology were present. Occasionally, macrophages or epithelial cells showed adipophilin-positivity, however, without co-expression of AR. Thymic sebaceous carcinoma should be considered if a thymic carcinoma shows clear or foamy features. Testing for FGFR2 amplification might be warranted when searching for actionable genomic alterations in sebaceous carcinomas in the mediastinum and in other locations.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Über diesen Artikel

Weitere Artikel der Ausgabe 2/2020

Virchows Archiv 2/2020 Zur Ausgabe

Neu im Fachgebiet Pathologie

15.06.2020 | Dermatologische Diagnostik | Schwerpunkt: Diagnose entzündlicher Dermatosen | Ausgabe 4/2020

Moderne Diagnostik bullöser Autoimmundermatosen

04.06.2020 | Alopezie | Schwerpunkt: Diagnose entzündlicher Dermatosen | Ausgabe 4/2020

Alopezien – kühlen Kopf bewahren!