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25.11.2020 | Letter to the Editor

Potentially serious consequences for the use of Bitrex as a deterrent for the intentional inhalation of computer duster sprays

verfasst von: Brian E. Perron, Joseph M. Haroney, David E. Hayes, Rebeccah L. Sokol, Seth A. Kolton

Erschienen in: Forensic Toxicology | Ausgabe 1/2021

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Dear Editor, …

Howard MO, Bowen SE, Garland EL, Perron BE, Vaughn MG (2011) Inhalant use and inhalant use disorders in the United States. Addict Sci ClinPract 6:18–31 (PMID:22003419, open access article)

Kurniali PC, Henry L, Kurl R, Meharg JV (2012) Inhalant abuse of computer cleaner manifested as angioedema. Am J Emerg Med 30:265.e3-e5. https://doi.org/10.1016/j.ajem.2010.12.003CrossRef

Kahn SA, Bierman TV, Larson KJ, Blache AL (2019) Killing brain cells and skin cells simultaneously with inhalant abuse: pearls from the National Burn Repository. J Burn Care Res 40:347–348. https://doi.org/10.1093/jbcr/irz025CrossRefPubMed

Winston A, Kanzy A, Bachuwa G (2015) Air Duster abuse causing rapid airway compromise. BMJ Case Rep 2015:bcr2014207566. https://doi.org/10.1136/bcr-2014-207566CrossRefPubMedPubMedCentral

Dingle HE, Williams SR (2018) Multi-organ system injury from inhalant abuse. Prehosp Emerg Care 23:580–583. https://doi.org/10.1080/10903127.2018.1536771CrossRefPubMed

Avella J, Wilson JC, Lehrer M (2006) Fatal cardiac arrhythmia after repeated exposure to 1,1-difluoroethane (DFE). Am J Forensic Med Pathol 27:58–60. https://doi.org/10.1097/01.paf.0000202715.71009.0eCrossRefPubMed

Sakai K, Maruyama-Maebashi K, Takatsu A, Fukui K, Nagai T, Aoyagi M, Ochiai A, Iwadate K (2011) Sudden death involving inhalation of 1,1-difluoroethane (HFC-152a) with spray cleaner: three case reports. Forensic Sci Int 206:e58–e61. https://doi.org/10.1016/j.forsciint.2010.08.026CrossRefPubMed

Xiong Z, Avella J, Wetli CV (2004) Sudden death caused by 1,1-difluoroethane inhalation. J Forensic Sci 49:627–629. https://doi.org/10.1520/JFS2003250CrossRefPubMed

Hahn T, Avella J, Lehrer M (2006) A motor vehicle accident fatality innvolving the inhalation of 1,1-difluoroethane. J Anal Toxicol 30:638–642. https://doi.org/10.1093/jat/30.8.638 (open access article)CrossRefPubMed

10.

Garland EL, Howard MO (2012) Volatile substance misuse : clinical considerations, neuropsychopharmacology and potential role of pharmacotherapy in management. CNS Drugs 26:927–935. https://doi.org/10.1007/s40263-012-0001-6CrossRefPubMed

11.

Marsolek MR, White NC, Litovitz TL (2010) Inhalant abuse: monitoring trends by using poison control data, 1993–2008. Pediatrics 125:906–913. https://doi.org/10.1542/peds.2009-2080 (Open access article)CrossRefPubMed

12.

Ernstgård L, Sjögren B, Dekant W, Schmidt T, Johanson G (2012) Uptake and disposition of 1,1-difluoroethane (HFC-152a) in humans. Toxicol Lett 209:21–29. https://doi.org/10.1016/j.toxlet.2011.11.028CrossRefPubMed

13.

ECETOC (2004) JACC Report 45 — 1,1-difluoroethane (HFC-152a). https://www.ecetoc.org/publication/jacc-report-45-11-difluoroethane-hfc-152a/. Accessed 14 Jun 2019

14.

Avella J, Kunaparaju N, Kumar S, Lehrer M, Zito SW, Barletta M (2010) Uptake and distribution of the abused inhalant 1,1-difluoroethane in the rat. J Anal Toxicol 34:381–388. https://doi.org/10.1093/jat/34.7.381 (Open access article)CrossRefPubMed

15.

Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL (2005) Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci 26:503–510. https://doi.org/10.1016/j.tips.2005.08.006 (Open access article)CrossRefPubMed

16.

Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Trudell J, Vissel B, Eger EI II (2003) Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. https://doi.org/10.1213/01.ANE.0000081063.76651.33 (Open access article)CrossRefPubMed

17.

Urban BW (2002) Current assessment of targets and theories of anaesthesia. Br J Anaesth 89:167–183. https://doi.org/10.1093/bja/aef165 (open access article)CrossRefPubMed

18.

Stachnik J (2006) Inhaled anesthetic agents. Am J Health Syst Pharm 63:623–634. https://doi.org/10.2146/ajhp050460CrossRefPubMed

19.

Borghese CM (2015) The molecular pharmacology of volatile Anesthetics. Int Anesthesiol Clin 53:28–39. https://doi.org/10.1097/AIA.0000000000000060CrossRefPubMedPubMedCentral

20.

Dart C (2010) SYMPOSIUM REVIEW: lipid microdomains and the regulation of ion channel function. J Physiol 588:3169–3178. https://doi.org/10.1113/jphysiol.2010.191585 (Open access article)CrossRefPubMedPubMedCentral

21.

Weinrich M, Worcester DL (2018) The actions of volatile anesthetics: a new perspective. Acta Crystallogr Sect Struct Biol D74:1169–1177. https://doi.org/10.1107/S2059798318004771CrossRef

22.

Walker DJ, Beckman NJ, Zacny JP (2004) Reinforcing and subjective effects of the volatile anesthetic, sevoflurane. Drug Alcohol Depend 76:191–201. https://doi.org/10.1016/j.drugalcdep.2004.05.002CrossRefPubMed

23.

The Cosmetic Ingredient Review Expert Panel (2008) Final report of the safety assessment of alcohol denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, quassin, brucine sulfate/brucine, and denatonium benzoate1. Int J Toxicol 27:1–43. https://doi.org/10.1080/10915810802032388 (open access article)CrossRef

24.

Hansen SR, Janssen C, Beasley VR (1993) Denatonium benzoate as a deterrent to ingestion of toxic substances: toxicity and efficacy. Vet Hum Toxicol 35:234–236 (PMID: 8351798)PubMed

25.

Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35:157–170. https://doi.org/10.1093/chemse/bjp092 (open access article)CrossRefPubMed

26.

Clark AA, Dotson CD, Elson AET, Voigt A, Boehm U, Meyerhof W, Steinle NI, Munger SD (2015) TAS2R bitter taste receptors regulate thyroid function. FASEB J 29:164–172. https://doi.org/10.1096/fj.14-262246 (open access article)CrossRefPubMed

27.

Deckmann K, Filipski K, Krasteva-Christ G, Fronius M, Althaus M, Rafiq A et al (2014) Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. Proc Natl Acad Sci USA 111:8287–8292. https://doi.org/10.1073/pnas.1402436111 (open access article)CrossRefPubMed

28.

Gu F, Liu X, Liang J, Chen J, Chen F, Li F (2015) Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts. Biochem Biophys Res Commun 463:934–941. https://doi.org/10.1016/j.bbrc.2015.06.038CrossRefPubMed

29.

Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E (2002) Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci 99:2392–2397. https://doi.org/10.1073/pnas.042617699 (open access article)CrossRefPubMed

30.

Deshpande DA, Wang WCH, Mcilmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JSK, Liggett SB (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med N Y 16:1299–1304. https://doi.org/10.1038/nm.2237 (open access article)CrossRef

31.

Belvisi MG, Dale N, Birrell MA, Canning BJ (2011) Bronchodilator activity of bitter tastants in human tissue. Nat Med 17:776. https://doi.org/10.1038/nm0711-776a (open access article)CrossRefPubMedPubMedCentral

32.

Liu D, Liman ER (2003) Intracellular Ca²+ and the phospholipid PIP₂ regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci USA 100:15160–15165. https://doi.org/10.1073/pnas.2334159100 (open access article)CrossRefPubMed

33.

Zhang Z, Zhao Z, Margolskee R, Liman E (2007) The transduction channel TRPM5 is gated by intracellular calcium in taste cells. J Neurosci 27:5777–5786. https://doi.org/10.1523/JNEUROSCI.4973-06.2007 (open access article)CrossRefPubMedPubMedCentral

34.

Berning CK, Griffith JF, Wild JE (1982) Research on the effectiveness of denatonium benzoate as a deterrent to liquid detergent ingestion by children. Fundam Appl Toxicol 2:44–48. https://doi.org/10.1016/s0272-0590(82)80063-8CrossRefPubMed

35.

Jackson MH, Payne HA (1995) Bittering agents: their potential application in reducing ingestions of engine coolants and windshield wash. Vet Hum Toxicol 37:323–326 (PMID: 8540219)PubMed

36.

Kappmeier K (2006) New Dust-Off® formula deters inhalant abuse. In: PRWeb. https://www.prweb.com/releases/2006/10/prweb461265.htm. Accessed 12 Jun 2019

37.

Creazzo JA, Jepson GW, Mas G (2007) Liquefied-gas aerosol dusting composition containing denatonium benzoate. United States Patent US 7,754,096 B2. https://patentimages.storage.googleapis.com/02/9f/1f/044edd8fdb041d/US7754096.pdf. Accessed 12 June 2019

38.

Office of the Federal Register (1983) Federal Register. 48:49205–49498. https://www.govinfo.gov/content/pkg/FR-1983-10-25/pdf/FR-1983-10-25.pdf. Accessed 12 June 2019

39.

Jaggupilli A, Howard R, Upadhyaya JD, Bhullar RP, Chelikani P (2016) Bitter taste receptors: novel insights into the biochemistry and pharmacology. Int J Biochem Cell Biol 77:184–196. https://doi.org/10.1016/j.biocel.2016.03.005CrossRefPubMed

40.

Clifford RL, Knox AJ (2012) Future bronchodilator therapy: a bitter pill to swallow? Am J Physiol-Lung Cell Mol Physiol 303:L953–L955. https://doi.org/10.1152/ajplung.00303.2012 (open access article)CrossRefPubMed

41.

Liggett SB (2013) Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert Opin Ther Targets 17:721–731. https://doi.org/10.1517/14728222.2013.782395CrossRefPubMedPubMedCentral

42.

Carpenter RL, Eger EI II, Johnson BH, Unadkat JD, Sheiner LB (1986) Pharmacokinetics of inhaled anesthetics in humans: measurements during and after the simultaneous administration of enflurane, halothane, isoflurane, methoxyflurane, and nitrous oxide. Anesth Analg 65:575–582 (PMID:3706798)CrossRef

43.

Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA (2014) Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest 124:1393–1405. https://doi.org/10.1172/JCI72094 (open access article)CrossRefPubMedPubMedCentral

44.

Hariri BM, McMahon DB, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ (2017) Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa. PLoS One 12:e0185203. https://doi.org/10.1371/journal.pone.0185203 (open access article)CrossRefPubMedPubMedCentral

45.

Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P et al (2012) European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl 23:1–298. https://doi.org/10.4193/Rhino12.000 (open access article)CrossRef

46.

Workman AD, Brooks SG, Kohanski MA, Blasetti MT, Cowart BJ, Mansfield C, Kennedy DW, Palmer JN, Adappa ND, Reed DR, Cohen NA (2018) Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis. J Allergy Clin Immunol Pract 6:1078–1080. https://doi.org/10.1016/j.jaip.2017.09.014 (open access article)CrossRefPubMed

47.

Carey RM, Workman AD, Hatten KM, Siebert AP, Brooks SG, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA (2017) Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes. Int Forum Allergy Rhinol 7:699–704. https://doi.org/10.1002/alr.21949CrossRefPubMedPubMedCentral

48.

Hayes JE, Wallace MR, Knopik VS, Herbstam DM, Bartoshuk LM, Duffy VB (2011) Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem Senses 36:311–319. https://doi.org/10.1093/chemse/bjq132 (open access article)CrossRefPubMed

49.

US Food and Drug Administration (2017) Legal requirements for the sale and purchase of drug products containing pseudoephedrine, ephedrine, and phenylpropanolamine. https://www.fda.gov/drugs/information-drug-class/legal-requirements-sale-and-purchase-drug-products-containing-pseudoephedrine-ephedrine-and. Accessed 12 Jun 2019

Titel: Potentially serious consequences for the use of Bitrex as a deterrent for the intentional inhalation of computer duster sprays
verfasst von: Brian E. Perron
Joseph M. Haroney
David E. Hayes
Rebeccah L. Sokol
Seth A. Kolton
Publikationsdatum: 25.11.2020
Verlag: Springer Singapore
Erschienen in: Forensic Toxicology / Ausgabe 1/2021
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-020-00559-2

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