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01.06.2017 | Original Article

PPARγ and ADRB3 polymorphisms analysis and Irisin expression in professional water polo players

verfasst von: Olga Scudiero, Ersilia Nigro, Ausilia Elce, Viviana Izzo, Maria Ludovica Monaco, Dino Sangiorgio, Pasqualina Buono, Giovanni Villone, Aurora Daniele

Erschienen in: Sport Sciences for Health | Ausgabe 2/2017

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Abstract

Background

Response to exercise is regulated by environmental factors and genetic predisposition. PPARγ and ADRB3 genes are associated with body composition. Adipose and muscle tissues secrete adipokines and myokines involved in energy expenditure; among the others, adiponectin and Irisin were associated with benefits of physical activity.

Aims

Here we investigate two common variants in PPARγ and ADRB3 genes (Pro12Ala, Trp64Arg, respectively) and the expression of Irisin in 22 professional water polo (WP) players versus 40 controls.

Methods

Anthropometric and hormonal parameters were assessed; Pro12Ala and Trp64Arg SNPs were analyzed by direct-sequencing; adiponectin and Irisin expression was evaluated through western blotting.

Results

Irisin levels were similar between WP athletes and controls. The Pro12Ala polymorphism was present in two WP players and two controls while the Trp64Arg polymorphism only in one WP player; both polymorphisms were not related to biochemical parameters, as well as to Irisin and adiponectin expression.

Conclusions

Our study suggests that the influence of two PPARγ and ADRB3 common polymorphisms on Adiponectin and Irisin expression in WP athletes is limited, if it exists at all. Further studies are needed to clarify if the positive effects mediated by physical training may pass through the regulation of Irisin, adiponectin and genetic background.

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Titel: PPARγ and ADRB3 polymorphisms analysis and Irisin expression in professional water polo players
verfasst von: Olga Scudiero
Ersilia Nigro
Ausilia Elce
Viviana Izzo
Maria Ludovica Monaco
Dino Sangiorgio
Pasqualina Buono
Giovanni Villone
Aurora Daniele
Publikationsdatum: 01.06.2017
Verlag: Springer Milan
Erschienen in: Sport Sciences for Health / Ausgabe 2/2017
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-017-0371-8

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Springer Medizin

PPARγ and ADRB3 polymorphisms analysis and Irisin expression in professional water polo players

Abstract

Background

Aims

Methods

Results

Conclusions

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Springer Medizin

Abstract

Background

Aims

Methods

Results

Conclusions

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