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2018 | Pränatale und perinatale Diagnostik | OriginalPaper | Buchkapitel

24. Hydrops fetalis, Anämie und Thrombozytopenie

verfasst von: Prof. Dr. med. U. Gembruch

Erschienen in: Ultraschalldiagnostik in Geburtshilfe und Gynäkologie

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Hydrops fetalis bezeichnet das Auftreten fetaler Wassereinlagerungen in mindestens zwei fetalen Kompartimenten. Wenn dem eine hämolytische Anämie durch gegen fetale Erythrozyten gerichtete maternale Alloantikörper zugrunde liegt, spricht man von einem immunologisch bedingten Hydrops fetalis (IHF). Die anderen über 150 fetale Erkrankungen umfassenden Ursachen eines Hydrops werden als nicht immunologisch bedingter Hydrops fetalis (NIHF) bezeichnet. Ursache, Diagnostik, Prognose und mögliche Therapie bei Vorliegen eines Hydrops fetalis werden in diesem Kapitel abgehandelt, insbesondere die in der Regel gut zu behandelnden Anämien des Feten. Ferner wird ausführlich auf die Diagnostik und Therapie fetaler Thrombozytopenien eingegangen.
Literatur
Zurück zum Zitat Adzick NS (2009) Management of fetal lung lesions. Clin Perinatol 36: 363–376 Adzick NS (2009) Management of fetal lung lesions. Clin Perinatol 36: 363–376
Zurück zum Zitat Adzick NS (2010) Open fetal surgery for life–threatening fetal anomalies. Semin Fetal Neonatal Med 15: 1–8 Adzick NS (2010) Open fetal surgery for life–threatening fetal anomalies. Semin Fetal Neonatal Med 15: 1–8
Zurück zum Zitat Altarescu G, Elda-Geva T, Grisaru-Granovsky S, Bonstein L, Miskin H, Varshver I, Margalioth EJ, Levy-Lahad E, Renbaum P (2012) Preimplantation genetic diagnosis for fetal neonatal alloimmune thrombocytopenia due to antihuman platelet antigen maternal antibodies. Obstet Gynecol 119: 338–343 Altarescu G, Elda-Geva T, Grisaru-Granovsky S, Bonstein L, Miskin H, Varshver I, Margalioth EJ, Levy-Lahad E, Renbaum P (2012) Preimplantation genetic diagnosis for fetal neonatal alloimmune thrombocytopenia due to antihuman platelet antigen maternal antibodies. Obstet Gynecol 119: 338–343
Zurück zum Zitat Amann C, Geipel A, Müller A, Heep A, Ritgen J, Stressig R, Kozlowski P, Gembruch U, Berg C (2011) Fetal anemia of unknown cause – a diagnostic challenge. Ultraschall Med 32 (Suppl 2): E115–E121 Amann C, Geipel A, Müller A, Heep A, Ritgen J, Stressig R, Kozlowski P, Gembruch U, Berg C (2011) Fetal anemia of unknown cause – a diagnostic challenge. Ultraschall Med 32 (Suppl 2): E115–E121
Zurück zum Zitat Arinsburg SA, Shaz BH, Westhoff C, Cushing MM (2012) Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia. Am J Hematol 87: 525–528 Arinsburg SA, Shaz BH, Westhoff C, Cushing MM (2012) Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia. Am J Hematol 87: 525–528
Zurück zum Zitat Bakchoul T, Greinacher A, Sachs UJ, Krautwurst A, Renz H, Harb H, Bein G, Newmann PJ, Santoso S (2013) Inhibition of HPA-1a alloantibody-mediated platelet destructionm by a deglycosylated antii-HPA-1a antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia. Blood 122: 321–327 Bakchoul T, Greinacher A, Sachs UJ, Krautwurst A, Renz H, Harb H, Bein G, Newmann PJ, Santoso S (2013) Inhibition of HPA-1a alloantibody-mediated platelet destructionm by a deglycosylated antii-HPA-1a antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia. Blood 122: 321–327
Zurück zum Zitat Bellini C, Hennekam RC, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E (2009) Etiology of nonimmune hydrops featlis: a systematic review. Am J Med Genet A 149 (A): 844–851 Bellini C, Hennekam RC, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E (2009) Etiology of nonimmune hydrops featlis: a systematic review. Am J Med Genet A 149 (A): 844–851
Zurück zum Zitat Bellini C, Donarini G, Paladini D, Calevo MG, Bellini T, Ramenghi LA, Hennekam RC (2015) Etiology of non-immune hydrops fetalis: an update. Am J Med Genet A 167A: 1082–1088 Bellini C, Donarini G, Paladini D, Calevo MG, Bellini T, Ramenghi LA, Hennekam RC (2015) Etiology of non-immune hydrops fetalis: an update. Am J Med Genet A 167A: 1082–1088
Zurück zum Zitat Berkowitz RL, Kolb EA, McFarland JG, Wissert M, Primani A, Lesser M, Bussel JB (2006) Parallel randomized trials of risk–based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol 107: 91–96 Berkowitz RL, Kolb EA, McFarland JG, Wissert M, Primani A, Lesser M, Bussel JB (2006) Parallel randomized trials of risk–based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol 107: 91–96
Zurück zum Zitat Bertrand G, Drame M, Martageix C, Kaplan C (2011) Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia. Blood 117: 3209–3213 Bertrand G, Drame M, Martageix C, Kaplan C (2011) Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia. Blood 117: 3209–3213
Zurück zum Zitat Bertrand G, Petermann R, Kaplan C (2014) Prediction of IVIG treatment efficiency in fetal/neonatal alloimmune thrombocytopenia. Blood 124: 654–655 Bertrand G, Petermann R, Kaplan C (2014) Prediction of IVIG treatment efficiency in fetal/neonatal alloimmune thrombocytopenia. Blood 124: 654–655
Zurück zum Zitat Bianchi S, Lista G, Castoldi F, Rustico M (2010) Congenital primary hydrothorax: effect of thoracoamniotic shunting on neonatal clinical outcome. J Matern Fetal Neonatal Med 23: 1225–1229 Bianchi S, Lista G, Castoldi F, Rustico M (2010) Congenital primary hydrothorax: effect of thoracoamniotic shunting on neonatal clinical outcome. J Matern Fetal Neonatal Med 23: 1225–1229
Zurück zum Zitat Boulot P, Cattaneo A, Taib J, Peray P, Lefort G, Hedon B, Laffargue F, Viala JL (1993) Hematologic values of fetal blood obtained by means of cordocentesis. Fetal Diagn Ther 8: 309–316 Boulot P, Cattaneo A, Taib J, Peray P, Lefort G, Hedon B, Laffargue F, Viala JL (1993) Hematologic values of fetal blood obtained by means of cordocentesis. Fetal Diagn Ther 8: 309–316
Zurück zum Zitat Braun T, Brauer M, Fuchs I, Czernik C, Dudenhausen JW, Henrich W, Sarioglu N (2010) Mirror syndrome: a systematic review of fetal associated conditions, maternal presentation and perinatal outcome. Fetal Diagn Ther 27: 191–203 Braun T, Brauer M, Fuchs I, Czernik C, Dudenhausen JW, Henrich W, Sarioglu N (2010) Mirror syndrome: a systematic review of fetal associated conditions, maternal presentation and perinatal outcome. Fetal Diagn Ther 27: 191–203
Zurück zum Zitat Bussel JB, Sola-Visner M (2009) Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia. Semin Perinatol 33: 35–42 Bussel JB, Sola-Visner M (2009) Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia. Semin Perinatol 33: 35–42
Zurück zum Zitat Bussel JB, Berkowitz RL, Lynch L, Lesser ML, Paidas MJ, Huang CL, McFarland JG (1996) Antenatal management of alloimmune thrombocytopenia with intravenous gamma-globulin: a randomized trial of the addition of low-dose steroid to intravenous gamma-globulin. Am J Obstet Gynecol 174: 1414–1423 Bussel JB, Berkowitz RL, Lynch L, Lesser ML, Paidas MJ, Huang CL, McFarland JG (1996) Antenatal management of alloimmune thrombocytopenia with intravenous gamma-globulin: a randomized trial of the addition of low-dose steroid to intravenous gamma-globulin. Am J Obstet Gynecol 174: 1414–1423
Zurück zum Zitat Bussel JB, Berkowitz RL, Hung C, Kolb EA, Wissert M, Primiani A, Tsaur FW, Macfarland JG (2010) Intracranial hemorrhage in alloimmune thrombocytopenia: stratified management to prevent recurrence in the subsequent affected fetus. Am J Obstet Gynecol 203: 135.e1–135.e14 Bussel JB, Berkowitz RL, Hung C, Kolb EA, Wissert M, Primiani A, Tsaur FW, Macfarland JG (2010) Intracranial hemorrhage in alloimmune thrombocytopenia: stratified management to prevent recurrence in the subsequent affected fetus. Am J Obstet Gynecol 203: 135.e1–135.e14
Zurück zum Zitat Cosmi E, Mari G, Delle Chiaie L, Detti L, Akiyama M, Murphy J, Stefos T, Ferguson 2nd JE, Hunter D, Hsu CD, Abuhamad A, Bahado-Singh R (2002) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. Am J Obstet Gynecol 187: 1290–1293 Cosmi E, Mari G, Delle Chiaie L, Detti L, Akiyama M, Murphy J, Stefos T, Ferguson 2nd JE, Hunter D, Hsu CD, Abuhamad A, Bahado-Singh R (2002) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. Am J Obstet Gynecol 187: 1290–1293
Zurück zum Zitat Courtier J, Schauer GM, Parer JT, Regenstein AC, Callen PW, Glenn OA (2012) Polymicrogyria in a fetus with human parvovirus B19 infection: a case with radiologic–pathologic correlation. Ultrasound Obstet Gynecol 40: 604–606 Courtier J, Schauer GM, Parer JT, Regenstein AC, Callen PW, Glenn OA (2012) Polymicrogyria in a fetus with human parvovirus B19 infection: a case with radiologic–pathologic correlation. Ultrasound Obstet Gynecol 40: 604–606
Zurück zum Zitat de Haan TR, van den Akker ES, Porcelijn L, Oepkes D, Kroes AC, Walther FJ (2008) Thrombocytopenia in hydropic fetuses with parvovirus B19 infection: incidence, treatment and correlation with fetal B19 viral load. BJOG 115: 76–81 de Haan TR, van den Akker ES, Porcelijn L, Oepkes D, Kroes AC, Walther FJ (2008) Thrombocytopenia in hydropic fetuses with parvovirus B19 infection: incidence, treatment and correlation with fetal B19 viral load. BJOG 115: 76–81
Zurück zum Zitat de Jong EP, Walther FJ, Kroes AC, Oepkes D (2011) Parvovirus B19 infection in pregnancy: new insights and management. Prenat Diagn 31: 419–425 de Jong EP, Walther FJ, Kroes AC, Oepkes D (2011) Parvovirus B19 infection in pregnancy: new insights and management. Prenat Diagn 31: 419–425
Zurück zum Zitat de Jong EP, Lindenburg IT, van Klink JM, Oepkes D, van Kamp IL, Walther FJ, Lopriore E (2012) Intrauterine transfusion for parvovirus B19 infection: long-term neurodevelopmental outcome. Am J Obstet Gynecol 206: 204. e1–204.e5 de Jong EP, Lindenburg IT, van Klink JM, Oepkes D, van Kamp IL, Walther FJ, Lopriore E (2012) Intrauterine transfusion for parvovirus B19 infection: long-term neurodevelopmental outcome. Am J Obstet Gynecol 206: 204. e1–204.e5
Zurück zum Zitat Detti L, Mari G (2003) Noninvasive diagnosis of fetal anemia. Clin Obstet Gynecol 46: 923–930 Detti L, Mari G (2003) Noninvasive diagnosis of fetal anemia. Clin Obstet Gynecol 46: 923–930
Zurück zum Zitat Detti L, Oz U, Guney I, Ferguson JE, Bahado-Singh RO, Mari G (2001) Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses: Doppler ultrasound velocimetry for timing the second intrauterine transfusion in fetuses with anemia from red cell alloimmunization. Am J Obstet Gynecol 185: 1048–1051 Detti L, Oz U, Guney I, Ferguson JE, Bahado-Singh RO, Mari G (2001) Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses: Doppler ultrasound velocimetry for timing the second intrauterine transfusion in fetuses with anemia from red cell alloimmunization. Am J Obstet Gynecol 185: 1048–1051
Zurück zum Zitat Detti L, Mari G, Akiyama M, Cosmi E, Moise Jr KJ, Stefor T, Conaway M, Deter R (2002) Longitudinal assessment of the middle cerebral artery peak systolic velocity in healthy fetuses and in fetuses at risk for anemia. Am J Obstet Gynecol 187: 937–939 Detti L, Mari G, Akiyama M, Cosmi E, Moise Jr KJ, Stefor T, Conaway M, Deter R (2002) Longitudinal assessment of the middle cerebral artery peak systolic velocity in healthy fetuses and in fetuses at risk for anemia. Am J Obstet Gynecol 187: 937–939
Zurück zum Zitat Dijkmans AC, de Jong EP, Dijkmans BA, Lopriore E, Vossen A, Walther FJ, Oepkes D (2012) Parvovirus B19 in pregnancy: prenatal diagnosis and management of fetal complications. Curr Opin Obstet Gynecol 24: 95–101 Dijkmans AC, de Jong EP, Dijkmans BA, Lopriore E, Vossen A, Walther FJ, Oepkes D (2012) Parvovirus B19 in pregnancy: prenatal diagnosis and management of fetal complications. Curr Opin Obstet Gynecol 24: 95–101
Zurück zum Zitat Fasano RM (2016) Hemolytic disease of the fetus and newborn in the molecular era. Semin Fetal Neonatal Med 21: 28–34 Fasano RM (2016) Hemolytic disease of the fetus and newborn in the molecular era. Semin Fetal Neonatal Med 21: 28–34
Zurück zum Zitat Gembruch U (2009) Fetal tachyarrhythmia. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd ed. Informa Healthcare, New York, p 461–481 Gembruch U (2009) Fetal tachyarrhythmia. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd ed. Informa Healthcare, New York, p 461–481
Zurück zum Zitat Gembruch U, Holzgreve W (2000) The fetus with nonimmune hydrops. In: Harrison MR, Evans MI, Adzick NS, Holzgreve W (eds) The unborn patient: the art and science of fetal therapy, 3rd ed. Saunders, Philadelphia, p 525–582 Gembruch U, Holzgreve W (2000) The fetus with nonimmune hydrops. In: Harrison MR, Evans MI, Adzick NS, Holzgreve W (eds) The unborn patient: the art and science of fetal therapy, 3rd ed. Saunders, Philadelphia, p 525–582
Zurück zum Zitat Gembruch U, Holzgreve W (2009) Cardiac diseases in association with hydrops fetalis. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd ed. Informa Healthcare, New York, p 483–514 Gembruch U, Holzgreve W (2009) Cardiac diseases in association with hydrops fetalis. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd ed. Informa Healthcare, New York, p 483–514
Zurück zum Zitat Ghevaert C, Wilcox DA, Fang J, Armour KL, Clark MR, Ouwehand WH, Williamson LM (2008) Developing recombinant HPA-1-a-specific antibodies with abrogated Fcγ receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. J Clin Invest 118: 2929–2935 Ghevaert C, Wilcox DA, Fang J, Armour KL, Clark MR, Ouwehand WH, Williamson LM (2008) Developing recombinant HPA-1-a-specific antibodies with abrogated Fcγ receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. J Clin Invest 118: 2929–2935
Zurück zum Zitat Gimovsky AC, Luzi P, Berghella V (2015) Lysosomal storage disease as an etiology of nonimmune hydrops. Am J Obstet Gynecol 212: 281–290 Gimovsky AC, Luzi P, Berghella V (2015) Lysosomal storage disease as an etiology of nonimmune hydrops. Am J Obstet Gynecol 212: 281–290
Zurück zum Zitat Gottschalk I, Gottschalk L, Stressig R, Ritgen J, Herberg U, Breuer J, Oberhoffer R, Willruth A, Strizek B, Geipel A, Gembruch U, Berg C (2017a) Ebstein’s anomaly of the tricuspid valve in the fetus – a multicenter experience. Ultraschall Med 38: 427–436 Gottschalk I, Gottschalk L, Stressig R, Ritgen J, Herberg U, Breuer J, Oberhoffer R, Willruth A, Strizek B, Geipel A, Gembruch U, Berg C (2017a) Ebstein’s anomaly of the tricuspid valve in the fetus – a multicenter experience. Ultraschall Med 38: 427–436
Zurück zum Zitat Gottschalk I, Jehle C, Herberg U, Breuer J, Brockmeier K, Bennink G, Hellmund A, Strizek B, Gembruch U, Geipel A, Berg C (2017b) Prenatal diagnosis of absent pulmonary valve syndrome from the 1st trimester onward: novel insights into pathophysiology, associated conditions and outcome of a rare cardiac defect. Ultrasound Obstet Gynecol 49: 637–642 Gottschalk I, Jehle C, Herberg U, Breuer J, Brockmeier K, Bennink G, Hellmund A, Strizek B, Gembruch U, Geipel A, Berg C (2017b) Prenatal diagnosis of absent pulmonary valve syndrome from the 1st trimester onward: novel insights into pathophysiology, associated conditions and outcome of a rare cardiac defect. Ultrasound Obstet Gynecol 49: 637–642
Zurück zum Zitat Gumuscu B, Thompson EI, Grovas AC, Zach TL, Warkentin PI, Coccia PF (2013) Successful unrelated cord blood transplantation for homozygous α-thalassemia. J Pediatr Hematol Oncol 35: 570–572 Gumuscu B, Thompson EI, Grovas AC, Zach TL, Warkentin PI, Coccia PF (2013) Successful unrelated cord blood transplantation for homozygous α-thalassemia. J Pediatr Hematol Oncol 35: 570–572
Zurück zum Zitat Hudecova I, Chiu RW (2017) Non-invasive prenatal diagnosis of thalassemias using maternal plasma cell free DNA. Best Pract Res Clin Obstet Gynaecol 39: 63–73 Hudecova I, Chiu RW (2017) Non-invasive prenatal diagnosis of thalassemias using maternal plasma cell free DNA. Best Pract Res Clin Obstet Gynaecol 39: 63–73
Zurück zum Zitat Hellmund A, Berg C, Rösing B, Gembruch U, Geipel A (2012) Masked anemia due to cardiac tamponade in a hydropic fetus caused by placental chorioangioma. Ultrasound Obstet Gynecol 39: 479–480 Hellmund A, Berg C, Rösing B, Gembruch U, Geipel A (2012) Masked anemia due to cardiac tamponade in a hydropic fetus caused by placental chorioangioma. Ultrasound Obstet Gynecol 39: 479–480
Zurück zum Zitat Hellmund A, Berg C, Geipel A, Bludau M, Heydweiller A, Bachour H, Müller A, Müller A, Gembruch U (2016) Prenatal diagnosis and evaluation of sonographic predictors for intervention and adverse outcome in congenital pulmonary airway malformation. PLoS One 11:e0150474. Hellmund A, Berg C, Geipel A, Bludau M, Heydweiller A, Bachour H, Müller A, Müller A, Gembruch U (2016) Prenatal diagnosis and evaluation of sonographic predictors for intervention and adverse outcome in congenital pulmonary airway malformation. PLoS One 11:e0150474.
Zurück zum Zitat Hellmund A, Berg C, Geipel A, Bald R, Gembruch U (2017) Early intrauterine transfusion in fetuses with severe anemia caused by parvovirus B19 infection. Fetal Diagn Ther. doi: 10.​1159/​000477208 Hellmund A, Berg C, Geipel A, Bald R, Gembruch U (2017) Early intrauterine transfusion in fetuses with severe anemia caused by parvovirus B19 infection. Fetal Diagn Ther. doi: 10.​1159/​000477208
Zurück zum Zitat Huhta JC (2009) Congestive heart failure in the fetus. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd ed. Informa Healthcare, New York, p 561–578 Huhta JC (2009) Congestive heart failure in the fetus. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd ed. Informa Healthcare, New York, p 561–578
Zurück zum Zitat Jauniaux E, Pahal G, Gervy C, Gulbis B (2000) Blood biochemistry and endocrinology in the human fetus between 11 and 17 weeks of gestation. Reprod Biomed Online 1: 38–44 Jauniaux E, Pahal G, Gervy C, Gulbis B (2000) Blood biochemistry and endocrinology in the human fetus between 11 and 17 weeks of gestation. Reprod Biomed Online 1: 38–44
Zurück zum Zitat Kamphuis MM, Oepkes D (2011) Fetal and neonatal alloimmune thrombocytopenia: prenatal interventions. Prenat Diagn 31: 712–719 Kamphuis MM, Oepkes D (2011) Fetal and neonatal alloimmune thrombocytopenia: prenatal interventions. Prenat Diagn 31: 712–719
Zurück zum Zitat Kamphuis MM, Paridaans N, Porcelijn L, De Haas M, Van Der Schoot CE, Brand A, Bonsel GJ, Oepkes D (2010) Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review. BJOG 117: 1335–1343 Kamphuis MM, Paridaans N, Porcelijn L, De Haas M, Van Der Schoot CE, Brand A, Bonsel GJ, Oepkes D (2010) Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review. BJOG 117: 1335–1343
Zurück zum Zitat Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D (2014) Incidence and consequences of neonatal alloimmune thrombocytopenia: a systematic review. Pediatrics 133: 715–721 Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D (2014) Incidence and consequences of neonatal alloimmune thrombocytopenia: a systematic review. Pediatrics 133: 715–721
Zurück zum Zitat Kempe A, Rösing B, Berg C, Kamil D, Heep A, Gembruch U, Geipel A (2007) First-trimester treatment of fetal anemia secondary to parvovirus B19 infection. Ultrasound Obstet Gynecol 29: 226–228 Kempe A, Rösing B, Berg C, Kamil D, Heep A, Gembruch U, Geipel A (2007) First-trimester treatment of fetal anemia secondary to parvovirus B19 infection. Ultrasound Obstet Gynecol 29: 226–228
Zurück zum Zitat Kjeldsen-Kragh J, Skogen B (2013) Mechanisms and prevention of alloimmunization in pregnancy. Obstet Gynecol Surv 68: 526–532 Kjeldsen-Kragh J, Skogen B (2013) Mechanisms and prevention of alloimmunization in pregnancy. Obstet Gynecol Surv 68: 526–532
Zurück zum Zitat Kohl T, Van de Vondel P, Stressig R, Wartenberg HC, Heep A, Keiner S, Müller A, Franz A, Fröhlich S, Willinek W, Gembruch U (2009) Percutaneous fetoscopic laser decompression of congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia via a single trocar – current technical constraints and potential solutions for future interventions. Fetal Diagn Ther 25: 67–71 Kohl T, Van de Vondel P, Stressig R, Wartenberg HC, Heep A, Keiner S, Müller A, Franz A, Fröhlich S, Willinek W, Gembruch U (2009) Percutaneous fetoscopic laser decompression of congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia via a single trocar – current technical constraints and potential solutions for future interventions. Fetal Diagn Ther 25: 67–71
Zurück zum Zitat Koyama S, Tomimatsu T, Kanagawa T, Kumasawa K, Tsutsui T, Kimura T (2012) Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura. Am J Hematol 87: 15–21 Koyama S, Tomimatsu T, Kanagawa T, Kumasawa K, Tsutsui T, Kimura T (2012) Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura. Am J Hematol 87: 15–21
Zurück zum Zitat Krapp M, Kohl T, Simpson JM, Sharland GK, Katalinic A, Gembruch U (2003) Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia. Heart 89: 913–917 Krapp M, Kohl T, Simpson JM, Sharland GK, Katalinic A, Gembruch U (2003) Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia. Heart 89: 913–917
Zurück zum Zitat Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E (2016) Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature. Prenat Diagn 36: 1242–1249 Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E (2016) Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature. Prenat Diagn 36: 1242–1249
Zurück zum Zitat Lam YH, Tang MH (2002) Middle cerebral artery Doppler study in fetuses with homozygous alpha-thalassaemia-1 at 12–13 weeks of gestation. Prenat Diagn 22: 56–58 Lam YH, Tang MH (2002) Middle cerebral artery Doppler study in fetuses with homozygous alpha-thalassaemia-1 at 12–13 weeks of gestation. Prenat Diagn 22: 56–58
Zurück zum Zitat Lamont RF, Sobel JD, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, Kim SK, Uldbjerg N, Romero R (2011) Parvovirus B19 infection in human pregnancy. BJOG 118: 175–186 Lamont RF, Sobel JD, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, Kim SK, Uldbjerg N, Romero R (2011) Parvovirus B19 infection in human pregnancy. BJOG 118: 175–186
Zurück zum Zitat Le Toriellec E, Chenet C, Kaplan C (2013) Safe fetal platelet genotyping: new developments. Transfusion 53: 1755–1762 Le Toriellec E, Chenet C, Kaplan C (2013) Safe fetal platelet genotyping: new developments. Transfusion 53: 1755–1762
Zurück zum Zitat Lee FL, Said N, Grikscheit TC, Shin CE, Llanes A, Chmait RH (2012) Treatment of congenital pulmonary airway malformation induced hydrops fetalis via percutaneous sclerotherapy. Fetal Diagn Ther 31: 264–268 Lee FL, Said N, Grikscheit TC, Shin CE, Llanes A, Chmait RH (2012) Treatment of congenital pulmonary airway malformation induced hydrops fetalis via percutaneous sclerotherapy. Fetal Diagn Ther 31: 264–268
Zurück zum Zitat Lee HH, Mak AS, Poon CF, Leung KY (2017) Prenatal ultrasound monitoring of homozygous α0-thalassemia-induced fetal anemia. Best Pract Res Clin Obstet Gynaecol 39: 53–62 Lee HH, Mak AS, Poon CF, Leung KY (2017) Prenatal ultrasound monitoring of homozygous α0-thalassemia-induced fetal anemia. Best Pract Res Clin Obstet Gynaecol 39: 53–62
Zurück zum Zitat Leung TY, Lao TT (2012) Thalassaemia in pregnancy. Best Pract Res Clin Obstet Gynecol 26: 37–51 Leung TY, Lao TT (2012) Thalassaemia in pregnancy. Best Pract Res Clin Obstet Gynecol 26: 37–51
Zurück zum Zitat Leung KY, Cheong KB, Lee CP, Chan V, Lam YH, Tang M (2010) Ultrasonographic prediction of homozygous α0–thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: alone or in combination? Ultrasound Obstet Gynecol 35: 149–154 Leung KY, Cheong KB, Lee CP, Chan V, Lam YH, Tang M (2010) Ultrasonographic prediction of homozygous α0–thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: alone or in combination? Ultrasound Obstet Gynecol 35: 149–154
Zurück zum Zitat Li DZ, Yang YD (2017) Invasive prenatal diagnosis of fetal thalassemia. Best Pract Res Clin Obstet Gynaecol 39: 41–52 Li DZ, Yang YD (2017) Invasive prenatal diagnosis of fetal thalassemia. Best Pract Res Clin Obstet Gynaecol 39: 41–52
Zurück zum Zitat Lindenburg IT, Wolterbeek R, Oepkes D, Klumper FJ, Vandenbussche FP, van Kamp IL (2011) Quality control for intravascular intrauterine transfusion using cumulative sum (CUSUM) analysis for the monitoring of individual performance. Fetal Diagn Ther 29: 307–314 Lindenburg IT, Wolterbeek R, Oepkes D, Klumper FJ, Vandenbussche FP, van Kamp IL (2011) Quality control for intravascular intrauterine transfusion using cumulative sum (CUSUM) analysis for the monitoring of individual performance. Fetal Diagn Ther 29: 307–314
Zurück zum Zitat Lindenburg IT, Smits-Wintjens VE, van Klink JM, Verduin E, van Kamp IL, Walther FJ, Schonewille H, Doxiadis II, Kanhai HH, van Lith JM, van Zwet EW, Oepkes D, Brand A, Lopriore E (2012) Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study. Am J Obstet Gynecol 206: 141. e1–141.e8 Lindenburg IT, Smits-Wintjens VE, van Klink JM, Verduin E, van Kamp IL, Walther FJ, Schonewille H, Doxiadis II, Kanhai HH, van Lith JM, van Zwet EW, Oepkes D, Brand A, Lopriore E (2012) Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study. Am J Obstet Gynecol 206: 141. e1–141.e8
Zurück zum Zitat Lindenburg IT, van Klink JM, Smits-Wintjens VE, van Kamp IL, Oepkes D, Lopriore E (2013) Long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review. Prenat Diagn 33: 815–822 Lindenburg IT, van Klink JM, Smits-Wintjens VE, van Kamp IL, Oepkes D, Lopriore E (2013) Long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review. Prenat Diagn 33: 815–822
Zurück zum Zitat Lindenburg IT, van Kamp IL, Oepkes D (2014) Intrauterine blood transfusion: current indications and associated risks. Fetal Diagn Ther 36: 263–271 Lindenburg IT, van Kamp IL, Oepkes D (2014) Intrauterine blood transfusion: current indications and associated risks. Fetal Diagn Ther 36: 263–271
Zurück zum Zitat Loh KC, Jelin E, Hirose S, Feldstein V, Goldstein R, Lee H (2012) Microcystic congenital pulmonary airway malformation with hydrops fetalis: steroids vs open fetal resection. J Pediatr Surg 47: 36–39 Loh KC, Jelin E, Hirose S, Feldstein V, Goldstein R, Lee H (2012) Microcystic congenital pulmonary airway malformation with hydrops fetalis: steroids vs open fetal resection. J Pediatr Surg 47: 36–39
Zurück zum Zitat Mallmann MR, Geipel A, Bludau M, Matil K, Gottschalk I, Hoopmann M, Müller A, Bachour H, Heydweiller A, Gembruch U, Berg C (2016) Bronchopulmonary sequestration with massive pleural effusion: pleuroamniotic shunting vs intrafetal vascular laser ablation. Ultrasound Obstet Gynecol 44: 441–446 Mallmann MR, Geipel A, Bludau M, Matil K, Gottschalk I, Hoopmann M, Müller A, Bachour H, Heydweiller A, Gembruch U, Berg C (2016) Bronchopulmonary sequestration with massive pleural effusion: pleuroamniotic shunting vs intrafetal vascular laser ablation. Ultrasound Obstet Gynecol 44: 441–446
Zurück zum Zitat Mallmann MR, Graham V, Rösing B, Gottschalk I, Müller A, Gembruch U, Geipel A, Berg C (2017) Thoracoamniotic shunting for fetal hydrothorax: predictors of intrauterine course and postnatal outcome. Fetal Diagn Ther 41: 58–65 Mallmann MR, Graham V, Rösing B, Gottschalk I, Müller A, Gembruch U, Geipel A, Berg C (2017) Thoracoamniotic shunting for fetal hydrothorax: predictors of intrauterine course and postnatal outcome. Fetal Diagn Ther 41: 58–65
Zurück zum Zitat Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise Jr KJ, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado- Singh R, Berry S, Martinez-Poyer J, Blackwell SC (2000) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal redcell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. N Engl J Med 342: 9–14 Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise Jr KJ, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado- Singh R, Berry S, Martinez-Poyer J, Blackwell SC (2000) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal redcell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. N Engl J Med 342: 9–14
Zurück zum Zitat Mari G, Zimmermann R, Moise Jr KJ, Deter RL (2005) Correlation between middle cerebral artery peak systolic velocity and fetal hemoglobin after 2 previous intrauterine transfusions. Am J Obstet Gynecol 193: 1117–1120 Mari G, Zimmermann R, Moise Jr KJ, Deter RL (2005) Correlation between middle cerebral artery peak systolic velocity and fetal hemoglobin after 2 previous intrauterine transfusions. Am J Obstet Gynecol 193: 1117–1120
Zurück zum Zitat Mari G, Hanif F, Kruger M, Cosmi E, Santolaya-Forgas J, Treadwell MC (2007) Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth-restricted fetuses. Ultrasound Obstet Gynecol 29: 310–316 Mari G, Hanif F, Kruger M, Cosmi E, Santolaya-Forgas J, Treadwell MC (2007) Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth-restricted fetuses. Ultrasound Obstet Gynecol 29: 310–316
Zurück zum Zitat Martí-Carvajal AJ, Peña-Martí GE, Comunián-Carrasco G (2009) Medical treatments for idiopathic thrombocytopenic purpura during pregnancy. Cochrane Database Syst Rev 4: CD007722 Martí-Carvajal AJ, Peña-Martí GE, Comunián-Carrasco G (2009) Medical treatments for idiopathic thrombocytopenic purpura during pregnancy. Cochrane Database Syst Rev 4: CD007722
Zurück zum Zitat Merz WM, Kübler K, Fimmers R, Stoffel-Wagner B, Geipel A, Gembruch U (2012a) Circulating N-terminal pro-B-type natriuretic peptide in fetal anemia before and after treatment. Pediatr Res 72: 174–178 Merz WM, Kübler K, Fimmers R, Stoffel-Wagner B, Geipel A, Gembruch U (2012a) Circulating N-terminal pro-B-type natriuretic peptide in fetal anemia before and after treatment. Pediatr Res 72: 174–178
Zurück zum Zitat Merz WM, Patzwaldt F, Fimmers R, Stoffel-Wagner B, Gembruch U (2012b) Dual-colour flow cytometry for the analysis of fetomaternal haemorrhage during delivery. J Clin Pathol 65: 186–187 Merz WM, Patzwaldt F, Fimmers R, Stoffel-Wagner B, Gembruch U (2012b) Dual-colour flow cytometry for the analysis of fetomaternal haemorrhage during delivery. J Clin Pathol 65: 186–187
Zurück zum Zitat Moise KJ Jr (2008) Management of rhesus alloimmunization in pregnancy. Obstet Gynecol 112: 164–176 Moise KJ Jr (2008) Management of rhesus alloimmunization in pregnancy. Obstet Gynecol 112: 164–176
Zurück zum Zitat Moise KJ Jr, Argoti PS (2012) Management and prevention of red cell alloimmunization in pregnancy: a systematic review. Obstet Gynecol 120: 1132–1139 Moise KJ Jr, Argoti PS (2012) Management and prevention of red cell alloimmunization in pregnancy: a systematic review. Obstet Gynecol 120: 1132–1139
Zurück zum Zitat Moreno CA, Kanazawa T, Barini R, Nomura ML, Andrade KC, Gomes CP, Heinrich JK, Giugliani R, Burin M, Cavalcanti DP (2013) Non-immune hydrops fetalis: a prospective study of 53 cases. Am J Med Genet A161A: 3078–3086 Moreno CA, Kanazawa T, Barini R, Nomura ML, Andrade KC, Gomes CP, Heinrich JK, Giugliani R, Burin M, Cavalcanti DP (2013) Non-immune hydrops fetalis: a prospective study of 53 cases. Am J Med Genet A161A: 3078–3086
Zurück zum Zitat Nicolaides KH, Thilaganathan B, Mibashan RS (1989) Cordocentesis in the investigation of fetal erythropoiesis. Am J Obstet Gynecol 161: 1197–1200 Nicolaides KH, Thilaganathan B, Mibashan RS (1989) Cordocentesis in the investigation of fetal erythropoiesis. Am J Obstet Gynecol 161: 1197–1200
Zurück zum Zitat Oepkes D, Seaward PG, Vandenbussche FP, Windrim R, Kingdom J, Beyene J, Kanhai HH, Ohlsson A, Ryan G (2006) DIAMOND Study Group: Doppler ultrasonography versus amniocentesis to predict fetal anemia. N Engl J Med 355: 156–164 Oepkes D, Seaward PG, Vandenbussche FP, Windrim R, Kingdom J, Beyene J, Kanhai HH, Ohlsson A, Ryan G (2006) DIAMOND Study Group: Doppler ultrasonography versus amniocentesis to predict fetal anemia. N Engl J Med 355: 156–164
Zurück zum Zitat Pacheco LD, Berkowitz RL, Moise Jr KJ, Bussel JB, McFarland JG, Saade GR (2011) Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. Obstet Gynecol 118: 1157–1163 Pacheco LD, Berkowitz RL, Moise Jr KJ, Bussel JB, McFarland JG, Saade GR (2011) Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. Obstet Gynecol 118: 1157–1163
Zurück zum Zitat Paridaans NP, Kamphuis MM, Taune Wikman A, Tiblad E, van den Akker ES, Lopriore E, Challis D, Westgren M, Oepkes D (2015) Low-dose versus standard-dose intravenous immunglobulin to prevent fetal intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia: a randomized trial. Fetal Diagn Ther 38: 147–153 Paridaans NP, Kamphuis MM, Taune Wikman A, Tiblad E, van den Akker ES, Lopriore E, Challis D, Westgren M, Oepkes D (2015) Low-dose versus standard-dose intravenous immunglobulin to prevent fetal intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia: a randomized trial. Fetal Diagn Ther 38: 147–153
Zurück zum Zitat Pasman SA, van den Brink CP, Kamping MA, Adama van Scheltema PN, Oepkes D, Vandenbussche FP (2009) Total blood volume is maintained in nonhydropic fetuses with severe hemolytic anemia. Fetal Diagn Ther 26: 10–15 Pasman SA, van den Brink CP, Kamping MA, Adama van Scheltema PN, Oepkes D, Vandenbussche FP (2009) Total blood volume is maintained in nonhydropic fetuses with severe hemolytic anemia. Fetal Diagn Ther 26: 10–15
Zurück zum Zitat Picklesimer AH, Oepkes D, Moise Jr KJ, Kush ML, Weiner CP, Harman CR, Baschat AA (2007) Determinants of the middle cerebral artery peak systolic velocity in the human fetus. Am J Obstet Gynecol 197: 526.e1–526.e4 Picklesimer AH, Oepkes D, Moise Jr KJ, Kush ML, Weiner CP, Harman CR, Baschat AA (2007) Determinants of the middle cerebral artery peak systolic velocity in the human fetus. Am J Obstet Gynecol 197: 526.e1–526.e4
Zurück zum Zitat Pistorius LR, Smal J, de Haan TR, Page-Christiaens GC, Verboon-Maciolek M, Oepkes D, de Vries LS (2008) Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection. Fetal Diagn Ther 24: 491–494 Pistorius LR, Smal J, de Haan TR, Page-Christiaens GC, Verboon-Maciolek M, Oepkes D, de Vries LS (2008) Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection. Fetal Diagn Ther 24: 491–494
Zurück zum Zitat Porcelijn L, Van den Akker ES, Oepkes D (2008) Fetal thrombocytopenia. Semin Fetal Neonatal Med 13: 223–230 Porcelijn L, Van den Akker ES, Oepkes D (2008) Fetal thrombocytopenia. Semin Fetal Neonatal Med 13: 223–230
Zurück zum Zitat Rayment R, Brunskill SJ, Soothill PW, Roberts DJ, Bussel JB, Murphy MF (2011) Antenatal interventions for fetomaternal alloimmune thrombocytopenia. Cochrane Database Syst Rev 5: CD004226 Rayment R, Brunskill SJ, Soothill PW, Roberts DJ, Bussel JB, Murphy MF (2011) Antenatal interventions for fetomaternal alloimmune thrombocytopenia. Cochrane Database Syst Rev 5: CD004226
Zurück zum Zitat Ruano R, Ramalho AS, Cardoso AK, Moise Jr K, Zugaib M (2011) Prenatal diagnosis and natural history of fetuses presenting with pleural effusion. Prenat Diagn 31: 496–499 Ruano R, Ramalho AS, Cardoso AK, Moise Jr K, Zugaib M (2011) Prenatal diagnosis and natural history of fetuses presenting with pleural effusion. Prenat Diagn 31: 496–499
Zurück zum Zitat Scheffer PG, Ait Soussan A, Verhagen OJ, Page-Christiaens GC, Oepkes D, de Haas M, van der Schoot CE (2011a) Noninvasive fetal genotyping of human platelet antigen-1a. BJOG 118: 1392–1395 Scheffer PG, Ait Soussan A, Verhagen OJ, Page-Christiaens GC, Oepkes D, de Haas M, van der Schoot CE (2011a) Noninvasive fetal genotyping of human platelet antigen-1a. BJOG 118: 1392–1395
Zurück zum Zitat Scheffer PG, van der Schoot CE, Page-Christiaens GC, de Haas M (2011b) Noninvasive fetal blood group genotyping of rhesus D, c, E and of K in alloimmunised pregnant women: evaluation of a 7-year clinical experience. BJOG 118: 1340–1348 Scheffer PG, van der Schoot CE, Page-Christiaens GC, de Haas M (2011b) Noninvasive fetal blood group genotyping of rhesus D, c, E and of K in alloimmunised pregnant women: evaluation of a 7-year clinical experience. BJOG 118: 1340–1348
Zurück zum Zitat Scheier M, Hernandez-Andrade E, Fonseca EB, Nicolaides KH (2006) Prediction of severe fetal anemia in red blood cell alloimmunization after previous intrauterine transfusions. Am J Obstet Gynecol 195: 1550–1556 Scheier M, Hernandez-Andrade E, Fonseca EB, Nicolaides KH (2006) Prediction of severe fetal anemia in red blood cell alloimmunization after previous intrauterine transfusions. Am J Obstet Gynecol 195: 1550–1556
Zurück zum Zitat Schonewille H, Klumper FJ, van de Watering LM, Kanhai HH, Brand A (2007) High additional maternal red cell alloimmunization after Rhesus- and Kmatched intrauterine intravascular transfusions for hemolytic disease of the fetus. Am J Obstet Gynecol 196: 143.e1–143.e6 Schonewille H, Klumper FJ, van de Watering LM, Kanhai HH, Brand A (2007) High additional maternal red cell alloimmunization after Rhesus- and Kmatched intrauterine intravascular transfusions for hemolytic disease of the fetus. Am J Obstet Gynecol 196: 143.e1–143.e6
Zurück zum Zitat Serrarens-Janssen VM, Semmekrot BA, Novotny VM, Porcelijn L, Lotgering FK, Delemarre FM, Steegers EA (2008) Fetal/neonatal allo-immune thrombocytopenia (FNAIT): past, present, and future. Obstet Gynecol Surv 63: 239–252 Serrarens-Janssen VM, Semmekrot BA, Novotny VM, Porcelijn L, Lotgering FK, Delemarre FM, Steegers EA (2008) Fetal/neonatal allo-immune thrombocytopenia (FNAIT): past, present, and future. Obstet Gynecol Surv 63: 239–252
Zurück zum Zitat Simms RA, Liebling RE, Patel RR, Denbow ML, Abdel-Fattah SA, Soothill PW, Overton TG (2009) Management and outcome of pregnancies with parvovirus B19 infection over seven years in a tertiary fetal medicine unit. Fetal Diagn Ther 25: 373–378 Simms RA, Liebling RE, Patel RR, Denbow ML, Abdel-Fattah SA, Soothill PW, Overton TG (2009) Management and outcome of pregnancies with parvovirus B19 infection over seven years in a tertiary fetal medicine unit. Fetal Diagn Ther 25: 373–378
Zurück zum Zitat Slaghekke F, Kist WJ, Oepkes D, Pasman SA, Middeldorp JM, Klumper FJ, Walther FJ, Vandenbussche FP, Lopriore E (2010) Twin anemia-polycythemia sequence: diagnostic criteria, classification, perinatal management and outcome. Fetal Diagn Ther 27: 181–190 Slaghekke F, Kist WJ, Oepkes D, Pasman SA, Middeldorp JM, Klumper FJ, Walther FJ, Vandenbussche FP, Lopriore E (2010) Twin anemia-polycythemia sequence: diagnostic criteria, classification, perinatal management and outcome. Fetal Diagn Ther 27: 181–190
Zurück zum Zitat Slaghekke F, Pasman S, Veujoz M, Middeldorp JM, Lewi L, Devlieger R, Favre R, Lopriore E, Oepkes D (2015) Middle cerebral artery peak systolic velocity to predict fetal hemoglobin levels in twin anemia-polycythemia sequence. Ultrasound Obstet Gynecol 46: 432–436 Slaghekke F, Pasman S, Veujoz M, Middeldorp JM, Lewi L, Devlieger R, Favre R, Lopriore E, Oepkes D (2015) Middle cerebral artery peak systolic velocity to predict fetal hemoglobin levels in twin anemia-polycythemia sequence. Ultrasound Obstet Gynecol 46: 432–436
Zurück zum Zitat SMFM (Society of Maternal-Fetal Medicine); Norton ME, Chauhan SP, Dashe JS (2015a) Society of Maternal-Fetal Medicine (SFMF) Clinical Guideline #7: nonimmune hydrops fetalis. Am J Obstet Gynecol 212: 127–139 SMFM (Society of Maternal-Fetal Medicine); Norton ME, Chauhan SP, Dashe JS (2015a) Society of Maternal-Fetal Medicine (SFMF) Clinical Guideline #7: nonimmune hydrops fetalis. Am J Obstet Gynecol 212: 127–139
Zurück zum Zitat SMFM (Society of Maternal-Fetal Medicine); Mari G, Norton ME, Stone J, Berghella V, Sciscione AC, Tate D, Schenone MH (2015b) Society of Maternal-Fetal Medicine (SFMF) Clinical Guideline #8: the fetus at risk for anemia – diagnosis and management. Am J Obstet Gynecol 212: 697–710 SMFM (Society of Maternal-Fetal Medicine); Mari G, Norton ME, Stone J, Berghella V, Sciscione AC, Tate D, Schenone MH (2015b) Society of Maternal-Fetal Medicine (SFMF) Clinical Guideline #8: the fetus at risk for anemia – diagnosis and management. Am J Obstet Gynecol 212: 697–710
Zurück zum Zitat Smits-Wintjens VE, Rath ME, Lindenburg IT, Oepkes D, van Zwet EW, Walther FJ, Lopriore E (2012) Cholestasis in neonates with red cell alloimmune hemolytic disease: incidence, risk factors and outcome. Neonatology 101: 306–310 Smits-Wintjens VE, Rath ME, Lindenburg IT, Oepkes D, van Zwet EW, Walther FJ, Lopriore E (2012) Cholestasis in neonates with red cell alloimmune hemolytic disease: incidence, risk factors and outcome. Neonatology 101: 306–310
Zurück zum Zitat Swartz AE, Ruma MS, Kim E, Herring AH, Menard MK, Moise KJ Jr (2009) The effect of fetal heart rate on the peak systolic velocity of the fetal middle cerebral artery. Obstet Gynecol 113: 1225–1229 Swartz AE, Ruma MS, Kim E, Herring AH, Menard MK, Moise KJ Jr (2009) The effect of fetal heart rate on the peak systolic velocity of the fetal middle cerebral artery. Obstet Gynecol 113: 1225–1229
Zurück zum Zitat Takagi K, Tanaka H, Nishijima S, Masaoka N, Miyake Y, Sakata H, Satoh K (1989) Fetal blood values by percutaneous umbilical blood sampling. Fetal Ther 4: 152–160 Takagi K, Tanaka H, Nishijima S, Masaoka N, Miyake Y, Sakata H, Satoh K (1989) Fetal blood values by percutaneous umbilical blood sampling. Fetal Ther 4: 152–160
Zurück zum Zitat Tiblad E, Kublickas M, Ajne G, Bui TH, Ek S, Karlsson A, Wikman A, Westgren M (2011) Procedure-related complications and perinatal outcome after intrauterine transfusions in red cell alloimmunization in Stockholm. Fetal Diagn Ther 30: 266–273 Tiblad E, Kublickas M, Ajne G, Bui TH, Ek S, Karlsson A, Wikman A, Westgren M (2011) Procedure-related complications and perinatal outcome after intrauterine transfusions in red cell alloimmunization in Stockholm. Fetal Diagn Ther 30: 266–273
Zurück zum Zitat Tiller H, Kamphuis MM, Flodmark O, Papadogiannakis N, David AL, Sainio S, Koskinen S, Javela K, Wikman AT, Kekomaki R, Kanhai HH, Oepkes D, Husebekk A, Westgren M (2013) Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. BMJ Open Mar 22: 3(3). pii: e002490 Tiller H, Kamphuis MM, Flodmark O, Papadogiannakis N, David AL, Sainio S, Koskinen S, Javela K, Wikman AT, Kekomaki R, Kanhai HH, Oepkes D, Husebekk A, Westgren M (2013) Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. BMJ Open Mar 22: 3(3). pii: e002490
Zurück zum Zitat Tiller H, Husebekk A, Skogen B, Kjeldsen-Kragh J, Kjaer M (2016) True risk of fetal/neonatal alloimmune thrombocytopenia in subsequent pregnancies: a prospective observational follow-up study. BJOG 123: 738–44 Tiller H, Husebekk A, Skogen B, Kjeldsen-Kragh J, Kjaer M (2016) True risk of fetal/neonatal alloimmune thrombocytopenia in subsequent pregnancies: a prospective observational follow-up study. BJOG 123: 738–44
Zurück zum Zitat Traeger-Synodinos J, Harteveld CL, Old JM, Petrou M, Galanello R, Giordano P, Angastioniotis M, De la Salle B, Henderson S, May A; EMQN haemoglobinopathies best practice meeting (2015) EMQN Best Practice Guidelines for molecular and haematology methods for carrier identification and prenatal diagnosis of the haemoglobinopathies. Eur J Hum Genet 23: 426–437 Traeger-Synodinos J, Harteveld CL, Old JM, Petrou M, Galanello R, Giordano P, Angastioniotis M, De la Salle B, Henderson S, May A; EMQN haemoglobinopathies best practice meeting (2015) EMQN Best Practice Guidelines for molecular and haematology methods for carrier identification and prenatal diagnosis of the haemoglobinopathies. Eur J Hum Genet 23: 426–437
Zurück zum Zitat van den Akker ES, de Haan TR, Lopriore E, Brand A, Kanhai HH, Oepkes D (2008) Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies. Am J Obstet Gynecol 199: 387.e1–4 van den Akker ES, de Haan TR, Lopriore E, Brand A, Kanhai HH, Oepkes D (2008) Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies. Am J Obstet Gynecol 199: 387.e1–4
Zurück zum Zitat van der Schoot CE, Tax GH, Rijnders RJ, de Haas M, Christiaens GC (2003) Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed. Transfus Med Rev 17: 31–44 van der Schoot CE, Tax GH, Rijnders RJ, de Haas M, Christiaens GC (2003) Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed. Transfus Med Rev 17: 31–44
Zurück zum Zitat van Dongen H, Klumper FJ, Sikkel E, Vandenbussche FP, Oepkes D (2005) Noninvasive tests to predict fetal anemia in Kell-alloimmunized pregnancies. Ultrasound Obstet Gynecol 25: 341–315 van Dongen H, Klumper FJ, Sikkel E, Vandenbussche FP, Oepkes D (2005) Noninvasive tests to predict fetal anemia in Kell-alloimmunized pregnancies. Ultrasound Obstet Gynecol 25: 341–315
Zurück zum Zitat van Kamp IL, Klumper FJ, Oepkes D, Meerman RH, Scherjon SA, Vandenbussche FP, Kanhai HH (2005) Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization. Am J Obstet Gynecol 192: 171–177 van Kamp IL, Klumper FJ, Oepkes D, Meerman RH, Scherjon SA, Vandenbussche FP, Kanhai HH (2005) Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization. Am J Obstet Gynecol 192: 171–177
Zurück zum Zitat van Winden KR, Quintero RA, Kontopoulos EV, Korst LM, Llanes A, Chmait RH (2015) Pre-operative twin anemia/polycythemia in the setting of twin-twin transfusion syndrome (TTTS). Fetal Diagn Ther 37: 274–280 van Winden KR, Quintero RA, Kontopoulos EV, Korst LM, Llanes A, Chmait RH (2015) Pre-operative twin anemia/polycythemia in the setting of twin-twin transfusion syndrome (TTTS). Fetal Diagn Ther 37: 274–280
Zurück zum Zitat Vandenbussche FPHA, Brand A, Kanhai HHH (2011) Fetal thrombocytopenia. In: James D, Steer PJ, Weiner CP, Gonik B, Crowther CA, Robson SC (eds) High risk pregnancy: management options, 4th ed. Saunders, St. Louis, p 229–237 Vandenbussche FPHA, Brand A, Kanhai HHH (2011) Fetal thrombocytopenia. In: James D, Steer PJ, Weiner CP, Gonik B, Crowther CA, Robson SC (eds) High risk pregnancy: management options, 4th ed. Saunders, St. Louis, p 229–237
Zurück zum Zitat Vogel M, McElhinney DB, Wilkins-Haug LE, Marshall AC, Benson CB, Juraszek AL, Silva V, Lock JE, Marx GR, Tworetzky W (2011) Aortic stenosis and severe mitral regurgitation in the fetus resulting in giant left atrium and hydrops: pathophysiology, outcomes, and preliminary experience with pre-natal cardiac intervention. J Am Coll Cardiol 57: 348–355 Vogel M, McElhinney DB, Wilkins-Haug LE, Marshall AC, Benson CB, Juraszek AL, Silva V, Lock JE, Marx GR, Tworetzky W (2011) Aortic stenosis and severe mitral regurgitation in the fetus resulting in giant left atrium and hydrops: pathophysiology, outcomes, and preliminary experience with pre-natal cardiac intervention. J Am Coll Cardiol 57: 348–355
Zurück zum Zitat Weiner CP (2011) Fetal hemolytic disease. In: James D, Steer PJ, Weiner CP, Gonik B, Cowther CA, Robson SC (eds) High risk pregnancy: management options, 4th ed. Saunders, St. Louis, p 209–227 Weiner CP (2011) Fetal hemolytic disease. In: James D, Steer PJ, Weiner CP, Gonik B, Cowther CA, Robson SC (eds) High risk pregnancy: management options, 4th ed. Saunders, St. Louis, p 209–227
Zurück zum Zitat Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G (2017) Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. Blood 129: 1538–1547 Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G (2017) Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. Blood 129: 1538–1547
Zurück zum Zitat Witlox RS, Lopriore E, Oepkes D, Walther FJ (2011) Neonatal outcome after prenatal interventions for congenital lung lesions. Early Hum Dev 87: 611–618 Witlox RS, Lopriore E, Oepkes D, Walther FJ (2011) Neonatal outcome after prenatal interventions for congenital lung lesions. Early Hum Dev 87: 611–618
Zurück zum Zitat Wylie BJ, D’Alton ME (2010) Fetomaternal hemorrhage. Obstet Gynecol 115: 1039–1051 Wylie BJ, D’Alton ME (2010) Fetomaternal hemorrhage. Obstet Gynecol 115: 1039–1051
Zurück zum Zitat Yang YS, Ma GC, Shih JC, Chen CP, Chou CH, Yeh KT, Kuo SJ, Chen TH, Hwu WL, Lee TH, Chen M (2012) Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis. Ultrasound Obstet Gynecol 39: 56–62 Yang YS, Ma GC, Shih JC, Chen CP, Chou CH, Yeh KT, Kuo SJ, Chen TH, Hwu WL, Lee TH, Chen M (2012) Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis. Ultrasound Obstet Gynecol 39: 56–62
Zurück zum Zitat Yinon Y, Grisaru-Granovsky S, Chaddha V, Windrim R, Seaward PG, Kelly EN, Beresovska O, Ryan G (2010) Perinatal outcome following fetal chest shunt insertion for pleural effusion. Ultrasound Obstet Gynecol 36: 58–64 Yinon Y, Grisaru-Granovsky S, Chaddha V, Windrim R, Seaward PG, Kelly EN, Beresovska O, Ryan G (2010) Perinatal outcome following fetal chest shunt insertion for pleural effusion. Ultrasound Obstet Gynecol 36: 58–64
Zurück zum Zitat Yougbaré I, Lang S, Yang H, Chen P, Zhao X, Tai WS, Zdravic D, Vadasz B, Li C, Piran S, Marshall A, Zhu G, Tiller H, Killie MK, Boyd S, Leong-Poi H, Wen XY, Skogen B, Adamson SL, Freedman J, Ni H (2015) Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. J Clin Invest 125: 1545–1556 Yougbaré I, Lang S, Yang H, Chen P, Zhao X, Tai WS, Zdravic D, Vadasz B, Li C, Piran S, Marshall A, Zhu G, Tiller H, Killie MK, Boyd S, Leong-Poi H, Wen XY, Skogen B, Adamson SL, Freedman J, Ni H (2015) Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. J Clin Invest 125: 1545–1556
Metadaten
Titel
Hydrops fetalis, Anämie und Thrombozytopenie
verfasst von
Prof. Dr. med. U. Gembruch
Copyright-Jahr
2018
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-53662-9_24

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