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Current Osteoporosis Reports

Erschienen in:

26.11.2019 | Quality of Care in Osteoporosis (S Silverman and J Curtis, Section Editors)

Pragmatic Clinical Trials in Osteoporosis

verfasst von: Giovanni Adami, Kenneth G. Saag, Maria I. Danila

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2019

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Abstract

Purpose of Review

In this review, we present the application of pragmatic clinical trials for evaluating interventions in osteoporosis, and we discuss methodological considerations for designing and conducting a pragmatic clinical trial compared with a classical randomized clinical trial.

Recent Findings

Pragmatic clinical trials are a popular study design testing effectiveness of health interventions and are intended to address the limitations associated with traditional explanatory randomized clinical trials testing efficacy of interventions. To date, only few pragmatic clinical trials have been conducted in osteoporosis.

Summary

Pragmatic clinical trials are conducted under routine clinical practice setting and are intended to inform policy makers and clinical decisions. Osteoporosis is a chronic disease well-suited to this particular study design given the existence of a clear and specific natural endpoint, namely fracture occurrence, and the availability of several treatments to prevent fractures.

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Titel: Pragmatic Clinical Trials in Osteoporosis
verfasst von: Giovanni Adami
Kenneth G. Saag
Maria I. Danila
Publikationsdatum: 26.11.2019
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 6/2019
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00551-9

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