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Cancer Causes & Control

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29.11.2018 | Original paper

Pre- and perinatal factors and incidence of breast cancer in the Black Women’s Health Study

verfasst von: Lauren E. Barber, Kimberly A. Bertrand, Lynn Rosenberg, Tracy A. Battaglia, Julie R. Palmer

Erschienen in: Cancer Causes & Control | Ausgabe 1/2019

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Abstract

Purpose

The purpose of the study was to investigate the association between pre- or perinatal factors and breast cancer risk among African American women.

Methods

Participants in the Black Women’s Health Study, a prospective cohort of 59,000 African American women, reported birth weight, preterm birth, twin or triplet status, maternal age at birth, birth order, and having been breastfed during infancy at various times during follow-up from 1997 to 2015. Numbers of incident cases ranged from 312 for breastfed analyses to 1,583 for twin or triplet analyses. Using multivariable Cox proportional hazards regression, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between each factor and breast cancer risk overall and by estrogen receptor (ER) status.

Results

Compared to birth weights of 5 lbs. 8 oz.–8 lbs. 13 oz., low (< 5 lbs. 8 oz.) and high (> 8 lbs. 13 oz.) birth weights were associated with increased breast cancer risk; HRs (95% CI) were 1.19 (0.98–1.44) and 1.26 (0.97–1.63), respectively. Associations were similar by ER status. Having been born to a mother aged ≥ 35 years versus < 20 years was associated with risk of ER+ (HR 1.59, 95% CI 1.10–2.29), but not ER− breast cancer. Other perinatal factors were not associated with breast cancer.

Conclusion

African American women with a low or high birth weight or born to older mothers may have increased breast cancer risk. Trends towards delayed child birth and higher birth weights, coupled with disproportionately high rates of low birth weight among African Americans, may contribute to increases in breast cancer incidence.

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Titel: Pre- and perinatal factors and incidence of breast cancer in the Black Women’s Health Study
verfasst von: Lauren E. Barber
Kimberly A. Bertrand
Lynn Rosenberg
Tracy A. Battaglia
Julie R. Palmer
Publikationsdatum: 29.11.2018
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 1/2019
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-018-1103-3

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Pre- and perinatal factors and incidence of breast cancer in the Black Women’s Health Study

Abstract

Purpose

Methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Purpose

Methods

Results

Conclusion

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