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Clinical and Translational Oncology
Erschienen in: Clinical and Translational Oncology 9/2020

05.02.2020 | Review Article

Precision medicine in Ewing sarcoma: a translational point of view

verfasst von: P. Gargallo, A. Juan, Y. Yáñez, S. Dolz, V. Segura, V. Castel, A. Cañete

Erschienen in: Clinical and Translational Oncology | Ausgabe 9/2020

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Abstract

Ewing sarcoma is a rare tumor that arises in bones of children and teenagers but, in 15% of the patients it is presented as a primary soft tissue tumor. Balanced reciprocal chimeric translocation t(11;22)(q24;q12), which encodes an oncogenic protein fusion (EWSR1/FLI1), is the most generalized and characteristic molecular event. Using conventional treatments, (chemotherapy, surgery and radiotherapy) long-term overall survival rate is 30% for patients with disseminated disease and 65–75% for patients with localized tumors. Urgent new effective drug development is a challenge. This review summarizes the preclinical and clinical investigational knowledge about prognostic and targetable biomarkers in Ewing sarcoma, finally suggesting a workflow for precision medicine committees.
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Metadaten
Titel
Precision medicine in Ewing sarcoma: a translational point of view
verfasst von
P. Gargallo
A. Juan
Y. Yáñez
S. Dolz
V. Segura
V. Castel
A. Cañete
Publikationsdatum
05.02.2020
Verlag
Springer International Publishing
Erschienen in
Clinical and Translational Oncology / Ausgabe 9/2020
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-020-02298-7

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