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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 2/2018

19.02.2018 | Regenerative Biology and Medicine in Osteoporosis (T Webster, Section Editor)

Preclinical and Translational Studies in Small Ruminants (Sheep and Goat) as Models for Osteoporosis Research

verfasst von: Isabel R. Dias, José A. Camassa, João A. Bordelo, Pedro S. Babo, Carlos A. Viegas, Nuno Dourado, Rui L. Reis, Manuela E. Gomes

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2018

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Abstract

Purpose of the Review

This review summarizes research on the use of sheep and goats as large animal models of human osteoporosis for preclinical and translational studies.

Recent Findings

The most frequent osteoporotic sheep model used is the ovariectomized sheep with 12 months post-operatively or more and the combined treatment of ovariectomized sheep associated to calcium/vitamin D-deficient diet and glucocorticoid applications for 6 months, but other methods are also described, like pinealectomy or hypothalamic-pituitary disconnection in ovariectomized sheep. The goat model for osteoporosis research has been used in a very limited number of studies in osteoporosis research relative to sheep. These osteoporotic small ruminant models are applied for biomaterial research, bone augmentation, efficacy of implant fixation, fragility fracture-healing process improvement, or bone-defect repair studies in the osteopenic or osteoporotic bone.

Summary

Sheep are a recognized large animal model for preclinical and translational studies in osteoporosis research and the goat to a lesser extent. Recently, the pathophysiological mechanism underlying induction of osteoporosis in glucocorticoid-treated ovariectomized aged sheep was clarified, being similar to what occurs in postmenopausal women with glucocorticoid-induced osteoporosis. It was also concluded that the receptor activator of NF-κB ligand was stimulated in the late progressive phase of the osteoporosis induced by steroids in sheep. The knowledge of the pathophysiological mechanisms at the cellular and molecular levels of the induction of osteoporosis in small ruminants, if identical to humans, will allow in the future, the use of these animal models with greater confidence in the preclinical and translational studies for osteoporosis research.
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Metadaten
Titel
Preclinical and Translational Studies in Small Ruminants (Sheep and Goat) as Models for Osteoporosis Research
verfasst von
Isabel R. Dias
José A. Camassa
João A. Bordelo
Pedro S. Babo
Carlos A. Viegas
Nuno Dourado
Rui L. Reis
Manuela E. Gomes
Publikationsdatum
19.02.2018
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 2/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-018-0431-2

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Clinical and Research Approaches to Treat Non-union Fracture

Regenerative Biology and Medicine in Osteoporosis (T Webster, Section Editor)

Progress of Regenerative Therapy in Orthopedics

Biomechanics (G Niebur and J Wallace, Section Editors)

Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties

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Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)

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