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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Diabetology & Metabolic Syndrome 1/2014

Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes

Zeitschrift:
Diabetology & Metabolic Syndrome > Ausgabe 1/2014
Autoren:
Lenita Zajdenverg, Melanie Rodacki, Janaina Polo Faria, Maria Lúcia Elias Pires, José Egídio Paulo Oliveira, Vera Lúcia Castro Halfoun
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1758-5996-6-63) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no conflict of interest.

Authors' contribution

LZ contributed in the study design, study implementation, analysis and interpretation of data and major contribution to writing drafted the manuscript. MR drafted the manuscript. JPF contributed in the study implementation and in the manuscript writing. MLEP and JEPO contributed in the study implementation. VLCH contributed in the study design and in the interpretation of data. All authors read and approved the final manuscript.

Abstract

Abstract

Previous gestational diabetes mellitus (pGDM) indicates future risk for type 2 diabetes (T2DM). Insulin resistance (IR) may precede T2DM in many years and is associated with an increased risk for cardiovascular diseases.

Aim

This study aims to identify endothelial dysfunction and cardiovascular risk factors in women with pGDM.

Methods

This cross-sectional analysis included 45 non diabetic women, 20 pGDM and 25 controls, at least one year after delivery. Body mass index (BMI), abdominal circumference (AC), blood pressure, serum lipids, liver enzymes, uric acid, nonesterified fatty acids, C-reactive protein and plasma glucose, insulin, fibrinogen and plasminogen activator inhibitor 1 were measured. HOMA IR and β were calculated. Pre and post induced ischemia videocapillaroscopy was performed in hand nailfold to evaluate microvascular morphologic aspect and functional response.

Results

AC and fasting glucose were significantly higher in pGDM (p = 0.01 and p = 0.002 respectively). Women with pGDM and BMI < 25 kg/m2 had significantly higher levels of fasting insulin and HOMA IR than controls (p = 0.008 and 0.05 respectively). Abnormal morphologic findings were more frequent and papillae rectification were 3.3 times more prevalent in pGDM (p = 0.003). Other microvascular parameters did not differ between groups.

Conclusion

Cardiovascular risk factors and a microcirculation abnormality (papillae rectification) were significantly increased in young non-diabetic women with pGDM.
Zusatzmaterial
Authors’ original file for figure 1
13098_2013_334_MOESM1_ESM.pdf
Literatur
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