The online version of this article (doi:10.1186/s13195-016-0230-x) contains supplementary material, which is available to authorized users.
Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer’s dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT) in the general older population.
Our analyses focused on 2558 subjects from the prospective Three-City Study, a cohort of community-dwelling individuals aged 65 years and over, with FCSRT scores. Four “residual scores” and “risk scores” were built that included the FCSRT scores and socio-demographic variables. The predictive performance of crude, residual and risk scores was analyzed by comparing the areas under the ROC curve (AUC).
In total, 1750 subjects were seen 5 years after completing the FCSRT. AD was diagnosed in 116 of them. Compared with the crude free-recall score, the predictive performances of the residual score and of the risk score were not significantly improved (AUC: 0.83 vs 0.82 and 0.88 vs 0.89 respectively).
Using socio-demographic features in addition to the FCSRT does not improve its predictive performance for dementia or AD.
Additional file 1: is Table S1. presenting coefficients for the linear regression analyzing the relation between FCSRT scores and age, age-squared, sex and education. (DOCX 20 kb)13195_2016_230_MOESM1_ESM.docx
Additional file 2: is Table S2. presenting coefficients of logistic regression used for the construction of risk scores of Alzheimer’s dementia at 3 years and at 5 years based on age, sex, education, FCSRT scores and the interaction between socio-demographics factors and FCSRT scores. (DOCX 29 kb)13195_2016_230_MOESM2_ESM.docx
Gerstorf D, Herlitz A, Smith J. Stability of sex differences in cognition in advanced old age: the role of education and attrition. J Gerontol B Psychol Sci Soc Sci. 2006;61(4):245–9. CrossRef
Mura T, Amieva H, Goldberg M, Dartigues JF, Ankri J, Zins M, Berr C. Effect size for the main cognitive function determinants in a large cross-sectional study. Eur J Neurol. 2016;23(11):1614–26.
Williams JW, Plassman BL, Burke J, Holsinger T, Benjamin S. Preventing Alzheimer’s disease and cognitive decline. In: Evidence Report/Technology Assessment. Rockville: AHRQ: Agency for Healthcare Research and Quality; 2010.
The 3C Study Group. Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology. 2003;22(6):316–25. CrossRef
Van der linden M, Coyette F, Poitrenaud J, GREMEM elmd. L’épreuve de rappel libre/rappel indicé à 16 items (RL/RI–16). In: Van der Linden MAS, Agniel A, et les membres du GREMEM, editors. L’évaluation des troubles de la mémoire Présentation de quatre tests de mémoire épisodique (avec leur étalonnage). Marseille: Solal; 2004. p. 25–47.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
Lemos R, Maroco J, Simoes MR, Santiago B, Tomas J, Santana I. The free and cued selective reminding test for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: a prospective longitudinal study. J Neuropsychol. 2015. doi: 10.1111/jnp.12075. [Epub ahead of print].
- Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population
- BioMed Central