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Erschienen in:
14.06.2016 | Original Article
Predicting Severity of Acute Kidney Injury in Term Neonates with Perinatal Asphyxia Using Urinary Neutrophil Gelatinase Associated Lipocalin
Erschienen in: Indian Journal of Pediatrics | Ausgabe 12-13/2016
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Objective
To evaluate the utility of urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a biomarker for predicting Acute Kidney Injury (AKI) and its severity among neonates with perinatal asphyxia.
Methods
This descriptive study included 120 term neonates with perinatal asphyxia. Renal parameters of neonates were monitored and AKI was ascertained as per Acute Kidney Injury Network criteria. Urinary NGAL was estimated and correlated with severity of AKI.
Results
Among the 120 neonates with perinatal asphyxia, 55(46 %) had AKI. The median urinary NGAL level was 165 ng/ml (88.8–245.8) in neonates with AKI compared to 58.97(42.8–74.7) in those without AKI. The median NGAL was 134.45(112.2–162.5), 301.2(255.5–361.2), 416.2(412.2–465.5) in AKI stages 1, 2 and 3 respectively. An NGAL cut off value of 86.82 ng/ml had 87 % sensitivity and 87.7 % specificity in predicting AKI.
Conclusions
Urinary NGAL is a useful biomarker for predicting AKI and its severity among neonates with perinatal asphyxia.