Skip to main content
main-content

05.08.2019 | Urogenital | Ausgabe 1/2020

European Radiology 1/2020

Prediction of extraprostatic extension on multi-parametric magnetic resonance imaging in patients with anterior prostate cancer

Zeitschrift:
European Radiology > Ausgabe 1/2020
Autoren:
Hyungwoo Ahn, Sung Il Hwang, Hak Jong Lee, Hyoung Sim Suh, Gheeyoung Choe, Seok-Soo Byun, Sung Kyu Hong, Sangchul Lee, Joongyub Lee
Wichtige Hinweise

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Objectives

To validate how established markers of extraprostatic extension (EPE) are applied to anterior prostate cancers (APCs), and to investigate other novel markers if available.

Methods

Among 614 histopathologically confirmed APCs from 2011 to 2016, 221 lesions with PiRADS (verion 2) scores ≥ 4 on 3-T multi-parametric MRI were analyzed retrospectively. Two radiologists independently assessed capsular morphology qualitatively with 5-point scale (normal, thinning, bulging, loss, extracapsular disease), and capsule contact length (arc), tumor dimension, and their ratio (arc-dimension ratio) quantitatively. Reproducibility in measurement was assessed with κ and intra-class correlation coefficients (ICCs). Logistic regression analysis was done to find meaningful indicators of EPE. Diagnostic performance of markers was compared to one another with generalized linear model and multi-reader multi-case ROC analysis.

Results

Reproducibility was moderate to substantial (κ 0.45–0.73) for qualitative, and moderate to almost perfect (ICC 0.50–0.87) for quantitative features of EPE. Capsular morphology (odds ratio [OR] 1.818), capsule contact length (OR 1.115), tumor dimension (OR 1.035), and arc-dimension ratio (OR 1.846) were independently associated with EPE (p ≤ 0.019). Capsular bulging and capsule contact length of 10 mm as thresholds of EPE demonstrated sensitivity/specificity of 0.58/0.85 and 0.77/0.68, respectively. Capsule contact length yielded greatest AUC (0.784), followed by capsular morphology (0.778), arc-dimension ratio (0.749), and tumor dimension (0.741). Diagnostic performance of capsular morphology, capsule contact length, and arc-dimension ratio was comparable in predicting EPE.

Conclusions

Existing markers of EPE applicable regardless of locations of tumors apply similarly to APCs. Arc-dimension ratio may be a novel marker of EPE of APCs.

Key Points

• Existing imaging markers of extraprostatic extension (EPE) which have been applied regardless of locations of tumors are reflected similarly to anterior prostate cancers (APCs).
• Measuring tumor dimension without capsular assessment may result in insufficient pre-operative prediction of EPE of APCs.
• Arc-dimension ratio (capsule contact length divided by tumor dimension) exhibited highest OR and comparable performance to existing features in predicting EPE of APCs.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2020

European Radiology 1/2020 Zur Ausgabe
  1. Sie können e.Med Radiologie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.

Neu im Fachgebiet Radiologie

Meistgelesene Bücher aus der Radiologie

2016 | Buch

Medizinische Fremdkörper in der Bildgebung

Thorax, Abdomen, Gefäße und Kinder

Dieses einzigartige Buch enthält ca. 1.600 hochwertige radiologische Abbildungen und Fotos iatrogen eingebrachter Fremdmaterialien im Röntgenbild und CT.

Herausgeber:
Dr. med. Daniela Kildal

2011 | Buch

Atlas Klinische Neuroradiologie des Gehirns

Radiologie lebt von Bildern! Der vorliegende Atlas trägt dieser Tatsache Rechnung. Sie finden zu jedem Krankheitsbild des Gehirns Referenzbilder zum Abgleichen mit eigenen Befunden.

Autoren:
Priv.-Doz. Dr. med. Jennifer Linn, Prof. Dr. med. Martin Wiesmann, Prof. Dr. med. Hartmut Brückmann

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Radiologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise