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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

World Journal of Emergency Surgery 1/2015

Prediction of mortality in patients with colorectal perforation based on routinely available parameters: a retrospective study

Zeitschrift:
World Journal of Emergency Surgery > Ausgabe 1/2015
Autoren:
Takehito Yamamoto, Ryosuke Kita, Hideyuki Masui, Hiromitsu Kinoshita, Yusuke Sakamoto, Kazuyuki Okada, Junji Komori, Akira Miki, Kenji Uryuhara, Hiroyuki Kobayashi, Hiroki Hashida, Satoshi Kaihara, Ryo Hosotani
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

TY designed the study, acquired the data, analyzed and interpreted the data, and drafted and revised the manuscript. H Kobayashi helped to acquire the data and revise the manuscript. RK, HM, H Kinoshita, YS, KO, JK, AM, KU, HH, SK, and RH helped to revise the manuscript. All authors read and approved the final manuscript.

Abstract

Introduction

Even after surgery and intensive postoperative management, the mortality rate associated with colorectal perforation is high. Identification of mortality markers using routinely available preoperative parameters is important.

Methods

We enrolled consecutive patients with colorectal perforation who underwent operations from January 2010 to January 2015. We divided them into a mortality and survivor group and compared clinical characteristics between the two groups. Additionally, we compared the mortality rate between different etiologies: malignant versus benign and diverticular versus nondiverticular. We used the χ 2 and Mann–Whitney U tests and a logistic regression model to identify factors associated with mortality.

Results

We enrolled 108 patients, and 52 (48 %) were male. The mean age at surgery was 71 ± 13 years. The postoperative mortality rate was 12 % (13 patients). Multivariate logistic regression analysis showed that a high patient age (odds ratio [OR], 1.09; 95 % confidence interval [CI], 1.020–1.181) and low preoperative systolic blood pressure (OR, 0.98; 95 % CI, 0.953–0.999) were independent risk factors for mortality in patients with colorectal perforation. In the subgroup analysis, there was no significant difference between the malignant and benign group (11.8 % vs. 23.9 %, respectively; p = 0.970), while the diverticular group had a significantly lower mortality rate than the nondiverticular group (2.6 % vs. 17.1 %, respectively; p = 0.027).

Conclusions

Older patients and patients with low preoperative blood pressure had a high risk of mortality associated with colorectal perforation. For such patients, operations and postoperative management should be performed carefully.
Literatur
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