Background
Methods
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Group 1: patients with stage I and II.
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Group 2: patients with stage III and IV.
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Stage I: Stage in which the tumor is confined to the ovaries.
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Stage II: Stage in which the tumor involves one or both ovaries, with extension adjacent to pelvic tissues.
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Stage III: The tumor involves one or both ovaries, with cytology or confirmed histology of spreading out of the pelvis and with metastases to the retro peritoneum and / or lymph nodes.
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Stage IV: Advanced stage of cancer in which there is metastasis confirmed at a distance that excludes peritoneal metastasis.
Results
Group 1Stages I & II-FIGO | Group 2 Advanced ovarian cancer group Stages III & IV-FIGO |
P
| |
---|---|---|---|
n = 85 | n = 64 | ||
Civil Status | |||
Single | 20 (23.5%) | 17 (26.6%) | 0.829 |
Free union | 3 (3.5%) | 3 (4.7%) | |
Married | 42 (49.4%) | 34 (53.1%) | |
Divorcee | 4 (4.7%) | 2 (3.1%) | |
Widow | 16 (18.8%) | 8 (12.5%) | |
Place of residence | |||
Cuenca | 39 (45.9%) | 24 (37.5%) | 0.399 |
Machala | 9 (10.6%) | 4 (6.3%) | |
Gualaceo | 3 (3.5%) | 1 (1.6%) | |
Paute | 1 (1.2%) | 3 (4.7%) | |
Azogues | 5 (5.9%) | 7 (10.9%) | |
Others | 28 (32.9%) | 25 (39.1%) | |
Cancers Family Antecedents | 20 (23.5%) | 18 (28.1%) | 0.524 |
Breast Cancer Family History | 4 (4.7%) | 6 (9.4%) | 0.493 |
Hormonal Therapy History | 3 (3.5%) | 3 (4.7%) | 0.722 |
Biological state | |||
Premenopausal vs Postmenopausal | 20 (23.5%) | 27 (42.2%) | 0.015 |
Variable | Group 1 Stages I & II-FIGO n = 85 | Group 2 Advanced ovarian cancer group Stages III & IV-FIGO n = 64 |
P
|
---|---|---|---|
Histological type | |||
Serous | 75 (88.2%) | 46 (71.9%) | 0.024 |
Mucinous | 9 (10.6%) | 10 (15.6%) | |
Endometroid | 0 | 5 (7.8%) | |
Clear cells | 1 (1.2%) | 1 (1.6%) | |
Transitional cells | 0 | 2 (3.1%) |
Metastasis probability
B | S.E. | Wald | df | Sig. | Exp(B) | 95% C.I.for EXP(B) | ||
---|---|---|---|---|---|---|---|---|
Lower | Upper | |||||||
Step 2a | ||||||||
Age | 0.053 | .015 | 11.847 | 1 | 0.001 | 1.054 | 1.023 | 1.087 |
LOG CA-125 | 1.078 | .185 | 34.010 | 1 | < 0.0001 | 2.940 | 2.046 | 4.223 |
Constant | -8.163 | 1.415 | 33.295 | 1 | < 0.0001 | 0.000 |
B | S.E. | Wald | df | Sig. | Exp(B) | 95% C.I. for EXP(B) | ||
---|---|---|---|---|---|---|---|---|
Lower | Upper | |||||||
Step 1a | ||||||||
Age | 0.096 | 0.028 | 11.656 | 1 | 0.001 | 1.101 | 1.042 | 1.163 |
Pregnancies number | −0.098 | 0.083 | 1.406 | 1 | 0.236 | .907 | .771 | 1.066 |
LOG CA-125 | 1.034 | 0.185 | 31.236 | 1 | < 0.0001 | 2.812 | 1.957 | 4.040 |
Premenopause/Menopause [1] | 1.240 | 0.736 | 2.843 | 1 | 0.092 | 3.457 | .818 | 14.619 |
Constant | −10.27 | 1.975 | 27.045 | 1 | < 0.0001 | .000 |
B | Bootstrapa | |||||
---|---|---|---|---|---|---|
Bias | Std. Error | Sig. (2-tailed) | 95% Confidence Interval | |||
Lower | Upper | |||||
Step 1 | ||||||
LOG CA-125 | 1.078 | 0.049 | 0.215 | 0.001 | 0.781 | 1.639 |
Age | 0.053 | 0.002 | 0.018 | 0.002 | 0.024 | 0.095 |
Constant | −8.163 | −0.364 | 1.777 | 0.001 | −12.597 | −5.754 |