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Erschienen in: Breast Cancer Research and Treatment 1/2018

05.09.2017 | Letter to the Editor

Predictive role of loco-regional radiotherapy among metastatic breast cancer patients who had undergone primary tumor surgery

verfasst von: Kadri Altundag

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2018

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Excerpt

Dear Editor,I want to congratulate Yoo and colleagues for their article [1] in which they developed and validated a predictive model to identify long-term survivors among metastatic breast cancer patients who had undergone primary tumor surgery. Among these patients, advanced T-stage, high-grade tumor, lymphovascular invasion, negative estrogen receptor status, high Ki-67 expression, and abnormal CA 15-3 and alkaline phosphatase levels were associated with poor survival. However, the authors did not mention frequency of patients who received loco-regional radiotherapy (RT) which may affect survival of these patients. As associated with this, medical records of 227 patients with de novo stage IV breast cancer between April 1999 and January 2013 were retrospectively evaluated in our study [2]. In our study population, 188 (82.8%) patients had loco-regional treatment (LRT) [2 (1%) had loco-regional RT alone, 54 (29%) had surgery alone (mastectomy, n = 50; breast-conserving surgery (BCS), n = 4), and 132 (70%) had surgery (mastectomy, n = 119; BCS, n = 13) followed by loco-regional RT]. The median follow-up time was 35 months (range 4–149 months). The 5-year OS and PFS rates were significantly higher in patients treated with loco-regional RT than the ones who were not. In conclusion, our study results supported that addition of loco-regional RT increases the survival of metastatic breast cancer patients who had undergone primary tumor surgery. Therefore, loco-regional RT might be considered as an important independent variable to predict survival. …
Literatur
1.
Zurück zum Zitat Yoo TK, Chae BJ, Kim SJ, Lee J, Yoon TI, Lee SJ, Park HY, Park HK, Eom YH, Kim HS, Kim CJ, Shin MS, You SH, Song BJ (2017) Identifying long-term survivors among metastatic breast cancer patients undergoing primary tumor surgery. Breast Cancer Res Treat 165(1):109–118CrossRefPubMed Yoo TK, Chae BJ, Kim SJ, Lee J, Yoon TI, Lee SJ, Park HY, Park HK, Eom YH, Kim HS, Kim CJ, Shin MS, You SH, Song BJ (2017) Identifying long-term survivors among metastatic breast cancer patients undergoing primary tumor surgery. Breast Cancer Res Treat 165(1):109–118CrossRefPubMed
2.
Zurück zum Zitat Gultekin M, Yazici O, Eren G, Yuce D, Aksoy S, Ozisik Y, Guler N, Yazici G, Hurmuz P, Yildiz F, Altundag K, Gurkaynak M (2014) Impact of loco-regional treatment on survival in patients presented with metastatic breast carcinoma. Breast 23:775–783CrossRefPubMed Gultekin M, Yazici O, Eren G, Yuce D, Aksoy S, Ozisik Y, Guler N, Yazici G, Hurmuz P, Yildiz F, Altundag K, Gurkaynak M (2014) Impact of loco-regional treatment on survival in patients presented with metastatic breast carcinoma. Breast 23:775–783CrossRefPubMed
Metadaten
Titel
Predictive role of loco-regional radiotherapy among metastatic breast cancer patients who had undergone primary tumor surgery
verfasst von
Kadri Altundag
Publikationsdatum
05.09.2017
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 1/2018
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-017-4493-0

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