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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Sergio Raposeiras-Roubín, Bruno K Rodiño-Janeiro, Beatriz Paradela-Dobarro, Lilian Grigorian-Shamagian, José M García-Acuña, Pablo Aguiar-Souto, Michel Jacquet-Hervet, María V Reino-Maceiras, Ezequiel Álvarez, José R González-Juanatey
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-102) contains supplementary material, which is available to authorized users.
Sergio Raposeiras-Roubín, Bruno K Rodiño-Janeiro contributed equally to this work.

Competing interests

There is no competing interests that could be perceived as prejudicing the impartiality of the research reported.

Authors’ contributions

Design: SPR, BKRJ, LGS, JMGA, EÁ, JRGJ. Conduct/data collection: SRR, BKRJ, BPD, LGS, JMGA, PAS, MJH, MVRM, EÁ. Analysis: SRR, BKRJ, BPD, LGS, EÁ. Writing manuscript: SRR, BKRJ, LGS, EÁ, JRGJ. All authors read and approved the final manuscript.

Abstract

Background

Since post-infarction heart failure (HF) determines a great morbidity and mortality, and given the physiopathology implications of advanced glycation end products (AGE) in the genesis of myocardial dysfunction, it was intended to analyze the prognostic value of these molecules in order to predict post-infarction HF development.

Methods

A prospective clinical study in patients after first acute coronary syndrome was conducted. The follow-up period was consisted in 1 year. In 194 patients consecutively admitted in the coronary unit for myocardial infarct fluorescent AGE levels were measured. The association between glycaemic parameters and the development of post-infarction HF were analyzed in those patients. Finally, we identified the variables with independent predictor value by performing a multivariate analysis of Hazard ratio for Cox regression.

Results

Eleven out of 194 patients (5.6%) developed HF during follow-up (median: 1.0 years [0.8 - 1.5 years]). Even though basal glucose, fructosamine and glycated haemoglobin were significant predictive factors in the univariate analysis, after being adjusted by confounding variables and AGE they lost their statistical signification. Only AGE (Hazard Ratio 1.016, IC 95%: 1.006-1.026; p<0,001), together with NT-proBNP and the infarct extension were predictors for post-infarction HF development, where AGE levels over the median value 5-fold increased the risk of HF development during follow-up.

Conclusions

AGE are an independent marker of post-infarction HF development risk.
Zusatzmaterial
Authors’ original file for figure 1
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Authors’ original file for figure 2
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