Background
Methods
Study population and design
The diagnosis of POA
Ovarian stimulation, insemination, and IVF treatment
Hormonal measurements
Sample size calculation
Statistical analysis
Results
Baseline characteristics of the patients who were enrolled in the study (Tables 2, 3 and 4)
POA diagnosis
Age(years) | FSH levels (IU/L) | ||
---|---|---|---|
Mean(95%CI)a
| POA | Control | |
<33 | 7.71 (7.58–7.84) | ≥7.84 | <7.84 |
33 ~ 37 | 7.97 (7.82–8.12) | ≥8.12 | <8.12 |
38 ~ 41 | 8.14 (7.81–8.47) | ≥8.47 | <8.47 |
The correlation between POA and IVF outcomes
Characteristics | <33 years old |
t/z(χ
2
)
|
P
| |
---|---|---|---|---|
Control | POA | |||
n | 356 | 294 | ||
Age(y)a
| 28.64 ± 2.49 | 28.92 ± 2.37 | 1.462 | 0.144 |
Infertility years(y)a
| 3.84 ± 2.48 | 3.81 ± 2.34 | −0.140 | 0.889 |
BMI(kg/m2)a
| 21.30 ± 3.06 | 20.35 ± 2.27 | −4.528 | <0.001 |
FSH(IU/L)a
| 6.46 ± 1.03 | 9.21 ± 1.00 | 34.362 | <0.001 |
LH(IU/L)b
| 3.81(2.94–4.89) | 4. 78(3.62–5.82) | 44.850 | <0.001 |
E2(ng/L)b
| 38.00(25.90–51.00) | 37.77(26.00–50.58) | 0.039 | 0.844 |
FSH/LHb
| 1.76(1.32–2.18) | 1.95(1.57–2.50) | 20.869 | <0.001 |
AFC(n)a
| 16.14 ± 5.82 | 14.58 ± 5.25 | −3.554 | <0.001 |
Total dose of Gn (IU)a
| 1,874.20 ± 609.07 | 2,051.08 ± 612.17 | 3.639 | <0.001 |
E2 level on DHCG (ng/L)b
| 3,818.70 (2,413.24–4,800.00) | 3,563.50 (2,222.75–4,800.00) | 3.107 | 0.078 |
Number of retrieved oocytes(n)a
| 14.86 ± 7.35 | 12.55 ± 6.22 | −4.234 | <0.001 |
Rate of POR(%)c
| 1.42(5/353) | 6.46(19/294) | 11.585 | 0.001d
|
Number of frozen embryos (n)b
| 5.00(3.00–8.00) | 5.00(3.00–8.00) | 3.895 | 0.048 |
Number of available embryos (n)b
| 7.00(5.00–10.00) | 7.00(4.00–9.00) | 3.761 | 0.052 |
Fertilization rate(%)c
| 84.62(66.67–94.44) | 85.71(71.43–100.00) | 1.858 | 0.173 |
Cleavage rate(%)c
| 100.00 (100.00–100.00) | 100.00 (100.00–100.00) | 0.221 | 0.638 |
Cancellation rate(%)c
| 0.84(3/356) | 2.72(8/294) | 3.415 | 0.065e
|
Pregnancy rate (%)c
| 55.52(196/353) | 54.55(156/286) | 0.061 | 0.805 |
Characteristics | 33 ~ 37 years old |
t/z(χ
2
)
|
P
| |
---|---|---|---|---|
Control | POA | |||
n | 311 | 228 | ||
Age(y)a
| 34.82 ± 1.25 | 34.86 ± 1.32 | −0.327 | 0.744 |
Infertility years(y)a
| 5.67 ± 3.65 | 5.43 ± 3.54 | 0.736 | 0.462 |
BMI(kg/m2)a
| 21.89 ± 2.98 | 21.29 ± 2.98 | 2.336 | 0.020 |
FSH(IU/L)a
| 6.74 ± 1.10 | 9.64 ± 1.05 | −30.747 | <0.001 |
LH(IU/L)b
| 3.67(2.69–4.84) | 4. 47 (3.36–5.69) | 26.754 | <0.001 |
E2(ng/L)b
| 36.00(25.00–50.48) | 37.77(24.00–51.74) | 1.036 | 0.309 |
FSH/LHb
| 1.87(1.41–2.51) | 2.18(1.66–2.88) | 20.070 | <0.001 |
AFC(n)a
| 15.14 ± 6.30 | 12.98 ± 5.29 | 4.313 | <0.001 |
Total dose of Gn (IU)a
| 2,121.75 ± 766.98 | 2,470. 68 ± 812.84 | −5.087 | <0.001 |
E2 level on DHCG (ng/L)b
| 3,505.00 (2,276.75–4,800.00) | 2,804.00 (1,844.50–4,765.25) | 7.670 | 0.006 |
Number of retrieved oocytes(n)a
| 12.81 ± 6.88 | 11.06 ± 5.79 | 3.080 | 0.002 |
Rate of POR(%)c
| 4.50(14/311) | 8.77(20/228) | 4.059 | 0.044d
|
Number of frozen embryos (n)b
| 4.00(1.00–7.00) | 3.00(1.00–6.00) | 3.978 | 0.046 |
Number of available embryos (n)b
| 6.00(3.00–8.00) | 5.00(3.00–8.00) | 2.920 | 0.088 |
Fertilization rate (%)c
| 83.33(71.43–92.31) | 85.71(70.80–100.00) | 2.132 | 0.144 |
Cleavage rate (%)c
| 100.00 (100.00–100.00) | 100.00 (100.00–100.00) | 0.177 | 0.674 |
Cancellation rate(%)c
| 0. 96(3/311) | 2.60(6/228) | 2.226 | 0.136e
|
Pregnancy rate(%)c
| 46.43(143/308) | 42.79 (95/222) | 0.689 | 0.406 |
38 ~ 41 years old |
t/z(χ
2
)
|
p
| ||
---|---|---|---|---|
Control | POA | |||
n | 59 | 39 | ||
Age (y)a
| 39.07 ± 1.10 | 38.95 ± 1.05 | −0.535 | 0.594 |
Infertility years(y)a
| 6.95 ± 5.21 | 6.59 ± 4.08 | −0.387 | 0.700 |
BMI (kg/m2)a
| 22.36 ± 3.28 | 21.62 ± 1.64 | −1.481 | 0.142 |
FSH(IU/L)a
| 7.05 ± 0.97 | 9.79 ± 0.87 | 14.27 | <0.001 |
LH(IU/L)b
| 3.39(2.48–4.23) | 3.63(3.01–4.53) | −1.513 | 0.13 |
E2 (ng/L)b
| 35.95(29.60–49.80) | 39.71(31.38–53.97) | −0.947 | 0.344 |
FSH/LHb
| 2.12(1.63–2.84) | 2.84(2.13–3.20) | 10.175 | 0.001 |
AFC(n)a
| 11.17 ± 5.09 | 9.58 ± 3.33 | −1.705 | 0.092 |
Total dose of Gn (IU)a
| 2,633.63 ± 1000.45 | 3,388.92 ± 1638.73 | 2.778 | 0.007 |
E2 level on DHCG (ng/L)b
| 2,474.20 (1,789.25–3,954.14) | 2,437.00 (1,272.67–3,719.84) | 0.685 | 0.494 |
Number of retrieved oocytes (n)a
| 10.26 ± 5.75 | 8.36 ± 4.36 | −1.698 | 0.093 |
The rate of POR (%)c
| 5.08(3/59) | 20.51(8/39) | 5.609 | 0.018d
|
Number of frozen embryos (n)b
| 2.00(0.00–4.00) | 2.00(0.00–4.00) | −0.470 | 0.638 |
Number of available embryos (n)b
| 4.50(3.00–7.00) | 5.00(3.00–7.00) | −0.129 | 0.898 |
Fertilization rate (%)c
| 79.29(58.33–96.25) | 89.44(64.39–100.00) | −1.587 | 0.113 |
Cleave rage rate (%)c
| 98.75 (100.00–100.00) | 100.00 (100.00–100.0) | −1.941 | 0.052 |
Cancellation rate (%)c
| 1.70(1/59) | 7.69(3/39) | 2.157 | 0.142e
|
Pregnancy rate (%)c
| 25.86(15/58) | 34.29(12/36) | 0.606 | 0.436 |
<33 years | 33 ~ 37 years | 38 ~ 41 years | |||||||
---|---|---|---|---|---|---|---|---|---|
B |
P
| OR (95 % CI) | B |
P
| OR (95 % CI) | B |
P
| OR (5 % CI) | |
Age | 0.048 | 0.181 | 1.049(0.978–1.125) | −0.069 | 0.348 | 0.933(0.807–1.079) | −0.375 | 0.114 | 0.687(0.431–1.095) |
BMI | −0.185 | 0.000 | 0.831(0.776–0.891) | −0.090 | 0.006 | 0.914(0.857–0.975) | −0.125 | 0.193 | 0.882(0.730–1.065) |
AFC | −0.019 | 0.268 | 0.981(0.949–1.015) | −0.032 | 0.086 | 0.969(0.934–1.004) | −0.050 | 0.384 | 0.951(0.850–1.064) |
Number of retrieved oocytes | −0.043 | 0.002 | 0.958(0.933–0.984) | −0.015 | 0.348 | 0.985(0.954–1.017) | −0.036 | 0.489 | 0.965(0.872–1.068) |
Total dose of Gna
| 0.283 | <0.001 | 1.328(1.140–1.546) | 0.428 | <0.001 | 1.535(1.285–1.834) | 0.662 | 0.006 | 1.939(1.212–3.102) |
The correlation between POA and POR
B | S.E. | Wald |
P
| OR 95 % CI | |
---|---|---|---|---|---|
Age | 0.088 | 0.035 | 6.300 | 0.012 | 1.092(1.019–1.170) |
BMI | −0.005 | 0.046 | 0.011 | 0.917 | 0.995(0.910–1.089) |
AFC | −0.073 | 0.028 | 6.833 | 0.009 | 0.929(0.879–0.982) |
POA | 1.002 | 0.271 | 13.603 | 0.000 | 2.719(1.598–4.625) |
Concept | −5.244 | 1.556 | 11.357 |