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11.11.2015 | Maternal-Fetal Medicine

Predictive value of pregnancy-associated plasma protein-A (PAPP-A) and free beta-hCG on fetal growth restriction: results of a prospective study

verfasst von: Pietro Cignini, Laura Maggio Savasta, Ferdinando Antonio Gulino, Salvatore Giovanni Vitale, Lucia Mangiafico, Alvaro Mesoraca, Claudio Giorlandino

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2016

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Abstract

Purpose

Low levels of plasmatic pregnancy-associated plasma protein-A (PAPP-A) and high levels of free-beta human chorionic gonadotropin (beta-hCG) could influence the outcome of pregnancy. The objective of this study is to assess the correlation between PAPP-A and free beta-hCG and birth weight.

Materials and methods

Prospective follow-up study performed on 3332 patients in the first trimester of pregnancy who were subjected to a screening test focused on evaluation of fetal aneuploidy (SCA-TEST). The values of PAPP-A and free beta-hCG were both analyzed as raw values and subsequently converted to a multiple of the median (MoM). Statistical analysis was performed using SPSS version 17.0.1 (SPSS Inc., Chicago, USA).

Results

The incidence of “small for gestational age” in patients with PAPP-A MoM <1st and <5th ‰ was statistically significant (12 and 9.8 %; p < 0.0001). Also statistically significant data have been highlighted about free beta MoM > 95th ‰ (7 %; p = 0.03). The values of PAPP-A MoM > 99th ‰ are significantly correlated with an increased risk of “large for gestational age” (16.7 %; p < 0.0001).

Conclusion

Our study demonstrates that specific values of PAPP-A and free beta-hCG could identify the risk of low or high birth weight since the first trimester of pregnancy.

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Titel: Predictive value of pregnancy-associated plasma protein-A (PAPP-A) and free beta-hCG on fetal growth restriction: results of a prospective study
verfasst von: Pietro Cignini
Laura Maggio Savasta
Ferdinando Antonio Gulino
Salvatore Giovanni Vitale
Lucia Mangiafico
Alvaro Mesoraca
Claudio Giorlandino
Publikationsdatum: 11.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 6/2016
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3947-z

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Predictive value of pregnancy-associated plasma protein-A (PAPP-A) and free beta-hCG on fetal growth restriction: results of a prospective study

Abstract

Purpose

Materials and methods

Results

Conclusion

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