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20.08.2020 | Original Article | Ausgabe 2/2021

Heart and Vessels 2/2021

Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes

Zeitschrift:
Heart and Vessels > Ausgabe 2/2021
Autoren:
Chieh-Hua Lu, Dee Pei, Chung-Ze Wu, Hui-Chun Kua, Yao-Jen Liang, Yen-Lin Chen, Jiunn-Diann Lin
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00380-020-01681-2) contains supplementary material, which is available to authorized users.
Chieh-Hua Lu and Dee Pei have contributed equally to the study.

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Abstract

Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), with data obtained from 368 male and 428 female participants with T2DM. Multiple linear regression results were as follows. In male participants, body mass index (BMI) and creatinine (Cr) were associated with SSS (β = 0.224, p < 0.001; β = 0.140, p = 0.022, respectively), and only BMI was associated with SDS (β = 0.174, p = 0.004). In female participants, BMI and high-density lipoprotein cholesterol level were associated with SSS (β = 0.240, p < 0.001; β =  − 0.120, p = 0.048, respectively), and only BMI was correlated with SDS (β = 0.123, p = 0.031). Our multivariate logistic regression indicated that in male and female participants, BMI was the only independent indicator of high SSS (SSS ≥ 9). In this study, we demonstrated that male patients have a higher SSS and SDS than female patients do in Th-201 scans for T2DM in a Chinese population. For male and female patients, BMI was the strongest predictor of abnormality in Th-201 scans. Our results can help clinicians identify patients with T2DM at high risk of CAD.

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